Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review

Baino, Francesco; Fiorilli, Sonia Lucia; Vitale-Brovarone, C.

doi:10.3390/bioengineering4010015

Cited by 41 publications

(23 citation statements)

References 100 publications

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“…Mesoporous BGs (MBGs), which have been widely experimented as carriers for therapeutic ions and biomolecules and exhibit a controlled delivery capability for such agents [ 98 ], could partly overcome this problem by being embedded as high-added-value inclusions in biodegradable polymers. Many studies have been reported on the fabrication of MBG/polymer composites in the field of bone tissue engineering [ 99 ], but, to date, none of these constructs has been proposed for cardiac or lung tissue engineering. In general, applications in soft tissue engineering are dramatically scarce; only Jia et al [ 100 ] suggested the use of MBG/chitosan composite films to induce hemostasis and accelerate wound healing.…”

Section: Discussion and Future Challengesmentioning

confidence: 99%

Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering

2017

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Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies. Moreover, BGs can also act as a bioactive reinforcing phase to finely tune the mechanical properties of polymer-based constructs used to repair the damaged cardiac and pulmonary tissues. In the present study, we evaluated the potential of different forms of BGs, alone or in combination with other materials (e.g., polymers), in regards to repair and regenerate injured tissues of cardiac and pulmonary systems.

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Section: Discussion and Future Challengesmentioning

confidence: 99%

Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering

2017

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“…Natural tissues exhibit the unique ability of self-healing and repair, which synthetic implants do not have. A special class of recently-developed biomaterials, the so-called “hybrids”, are perhaps the very last frontier for obtaining implants with tissue-like properties [ 80 ]. Hybrid sol-gel materials are composed of interpenetrating networks of inorganic and organic phases, which are able to intimately interact at the nanoscale, thus allowing the whole material to behave as a single phase, unlike “conventional” nanocomposites [ 81 ].…”

Section: Grand Challenges For the Future—where Are We Going?mentioning

confidence: 99%

Bioactive Glasses: Where Are We and Where Are We Going?

Baino

Hamzehlou

Kargozar

2018

JFB

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370

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Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today’s achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine.

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“…The interested reader is addressed to a recent review dealing with composite systems and biomedical cements including bioactive phases …”

Section: Other Forms Of Applications: Coatings Fibres and Compositesmentioning

confidence: 99%

Bioactive sol‐gel glasses: Processing, properties, and applications

Baino

Fiume

Miola

et al. 2018

Int J Applied Ceramic Tech

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136

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Sol-gel route has shown its enormous potential in tissue engineering applications as an advantageous method for the production of bioactive glasses aimed at regenerating both hard and soft tissues. This review discusses the chemical aspects of the method with emphasis on the morphological, chemical, mechanical, and biological properties of sol-gel derived materials. The attention will be particularly focused on sol-gel bioactive glasses and sol-gel foam scaffolds for bone regeneration. The advantages deriving from the versatility of the sol-gel method compared to the traditional melt-quenching route will be underlined in terms of bioactivity, compositions, and processing parameters.

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Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review

Cited by 41 publications

References 100 publications

Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering

Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering

Bioactive Glasses: Where Are We and Where Are We Going?

Bioactive sol‐gel glasses: Processing, properties, and applications

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