Composite biocompatible hydroxyapatite–silk fibroin coatings for medical implants obtained by Matrix Assisted Pulsed Laser Evaporation

Miroiu, F.; Socol, G.; Visan, Anita Ioana; Stefan, N.; Crǎciun, D.; Crăciun, V.; Dorcioman, G.; Mihăilescu, I. N.; Sima, Livia Elena; Petrescu, Ştefana M.; Andronie, A.; Stamatin, I.; Moga, Sorin Georgian; Ducu, Cătălin

doi:10.1016/j.mseb.2009.10.004

Cited by 51 publications

(23 citation statements)

References 33 publications

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“…Generally surface morphology characteristics of fibroin‐based materials are the main information retrieved from the great majority of AFM studies. These data contribute to the interpretation of important experimental observations of fibroin containing systems, such as cell adhesion, optical performance, or self‐assembly behavior …”

Section: Physical–chemical Characterizationmentioning

confidence: 78%

Bombyx moriSilk Fibers: An Outstanding Family of Materials

Pereira

Silva

Bermúdez

2014

Macromol. Mater. Eng.

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Designing novel multifunctional materials from natural resources is a challenging goal that has increasingly attracted researchers. Recently, the great potential of silk fibers has been recognized. The target readers for this review are researchers from different backgrounds (i.e., non‐specialists in silk research) with special interests on the physical–chemical characterization of silk fibers, since their knowledge is crucial for the improvement of existent silk‐based biomaterials and the basis for the development of new products. Examples of usual applications of Bombyx mori silk fibers are given and some of the most recent and exciting progress in new technological fields, is presented.

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Section: Physical–chemical Characterizationmentioning

confidence: 78%

Bombyx moriSilk Fibers: An Outstanding Family of Materials

Pereira

Silva

Bermúdez

2014

Macromol. Mater. Eng.

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“…The examples include deposition calcium orthophosphate-based biocomposites with sodium maleate (Negroiu et al 2008), alendronate (Bigi et al 2009) and silk fibroin (Miroiu et al 2010). Thermally unstable calcium orthophosphates, such as OCP (Boanini et al 2012), might be deposited as well.…”

Section: Reviewmentioning

confidence: 99%

Calcium orthophosphate coatings, films and layers

Dorozhkin¹

2012

Prog Biomater

118

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In surgical disciplines, where bones have to be repaired, augmented or improved, bone substitutes are essential. Therefore, an interest has dramatically increased in application of synthetic bone grafts. As various interactions among cells, surrounding tissues and implanted biomaterials always occur at the interfaces, the surface properties of the implants are of the paramount importance in determining both the biological response to implants and the material response to the physiological conditions. Hence, a surface engineering is aimed to modify both the biomaterials, themselves, and biological responses through introducing desirable changes to the surface properties of the implants but still maintaining their bulk mechanical properties. To fulfill these requirements, a special class of artificial bone grafts has been introduced in 1976. It is composed of various mechanically stable (therefore, suitable for load bearing applications) biomaterials and/or bio-devices with calcium orthophosphate coatings, films and layers on their surfaces to both improve interactions with the surrounding tissues and provide an adequate bonding to bones. Many production techniques of calcium orthophosphate coatings, films and layers have been already invented and new promising techniques are continuously investigated. These specialized coatings, films and layers used to improve the surface properties of various types of artificial implants are the topic of this review.Electronic supplementary materialThe online version of this article (doi:10.1186/2194-0517-1-1) contains supplementary material, which is available to authorized users.

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“…The reason for the increase in mechanical properties could be due to strong ionic interaction between Ca +2 in β-TCP with COO -in gelatin and PO 4 -3 in β-TCP with NH 3+ in chitosan to strongly embed nanoceramic phase in gelatin-chitosan matrix that arrested and deflected crack propagation under the influence of stress. The mechanical properties of prepared GCT scaffolds were found to be significantly better than those of gelatin/chitosan scaffolds prepared by other groups using conventional methods [17].…”

Section: Mechanical Properties Of Prepared Scaffoldsmentioning

confidence: 67%

“…Osteoinductive properties of porous hybrid scaffolds prepared from β-TCP, alginate-gelatin was reported elsewhere [16]. Functionally graded HA/silk fibroin biocomposite prepared by pulse electric current sintering [17,18] showed excellent mechanical strength and osteoconductivity. Le et al proposed that the physical, chemical and biological properties of calcium orthophosphate bioceramics and the fibrin glue might cumulate in biocomposites suitable for preparation of advanced bone grafts [19].…”

Section: Introductionmentioning

confidence: 81%

Effect of βTricalcium Phosphate Nanoparticles Additions on the Properties of Gelatin-Chitosan Scaffolds

Maji¹,

Dasgupta²

2017

Bioceram Dev Appl

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Bone tissue engineering, using a synthetic porous scaffold material provides some distinct advantages over autografting and allografting, and it is a rapidly growing alternative approach to heal damaged bone tissue. The current study focuses on fabrication and characterization of nano β-TCP incorporated gelatin-chitosan based composite scaffold for bone regeneration at the sites of musculoskeletal defects and disorders.Gelatin-chitosan scaffold reinforced with beta-tricalcium phosphate (β-TCP) nanopowder was fabricated through freeze drying of material's suspension. From powder X-ray diffraction and Fourier transform infrared spectrometer analysis the presence of phase pure β-TCP powders in gelatin-chitosan matrix was confirmed. Gelatin-Chitosan-β-TCP (GCT) scaffold exhibited a homogenouos porous structure with an average pore size of 118 ± 11 µm. Micro-CT image confirmed interconnected porous network with homogeneous distribution of β-TCP nanoparticles in GelatinChitosan (GC) matrix. GCT scaffold showed higher compressive strength of 2.45 ± 0.15 MPa as compared to 1 MPa exhibited by neat GC scaffold. Protein adsorption capacity was increased to 22 mg/cc in GCT scaffold from 13 mg/ cc in GC scaffold. Weight loss of GCT scaffold was lower of 26% as compared to 47% in GC scaffold after 8 weeks of incubation in phosphate buffer solution of pH 7.4. Mesenchymal stem cells cultured onto GCT scaffold exhibited higher degree of lamellipodia and filopodia extensions and greater spreading onto GCT scaffold as compared to that in GC scaffold after 7 and 14 days of culture. MTT assay suggested higher degree of proliferation of MSCs cultured onto GCT scaffold as compared to that onto pure GC scaffolds. This study demonstrates that β-TCP incorporation into gelatin-chitosan matrix improved osteogenic potential of the scaffold suitable for bone tissue engineering.

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Composite biocompatible hydroxyapatite–silk fibroin coatings for medical implants obtained by Matrix Assisted Pulsed Laser Evaporation

Cited by 51 publications

References 33 publications

Bombyx moriSilk Fibers: An Outstanding Family of Materials

Bombyx moriSilk Fibers: An Outstanding Family of Materials

Calcium orthophosphate coatings, films and layers

Effect of βTricalcium Phosphate Nanoparticles Additions on the Properties of Gelatin-Chitosan Scaffolds

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