Composable paper-based analytical devices for determination of flavonoids

Gutorova, Svetlana V.; Apyari, V. V.; Kalinin, Vyacheslav I.; Furletov, Aleksei A.; Gorbunova, M. V.; Дмитриенко, С. Г.

doi:10.1016/j.snb.2020.129398

Cited by 14 publications

(7 citation statements)

References 60 publications

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“…The C–O band at 1045 cm −1 may be assigned to the polyols (i.e., flavones, terpenoids, and carbohydrates) present in the plant extract. The various assignments are consistent with those published in the literature for related compounds (Medina-Cruz et al 2020 ; Aref and Salem 2020 ; Gutorova et al 2021 ). These organic compounds were identified as stabilizing groups and capping agents that contributed to the silver ions reduction to metallic silver.…”

Section: Resultssupporting

confidence: 90%

“…Aqueous leaves extract of M. lucida contained alkaloids, flavonoids, tannins, terpenoids, anthraquinones, phlobatanin, carbohydrates, saponins, proteins, amino acids, and phytosterols while steroids, cardiac glycosides, reducing sugars, coumarin, and phenols were absent. According to Gutorova et al ( 2021 ), the presence of both alkaloids and flavonoids aids in the reduction in silver ions to generate AgNPs. Flavonoids were also found in green synthesized nanoparticles made from corn silk aqueous extract, according to Li et al ( 2020 ).…”

Section: Resultsmentioning

confidence: 99%

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Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

2022

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This study emphasizes the production of eco-friendly silver nanoparticles from a medicinal plant extract of Morinda lucida (M. lucida) and investigated its antioxidant and antimicrobial activity. Phytochemical screening of M. lucida (ML) leave extract was carried out and observed to contain some fundamental phyto-reducing agents such as reducing sugar, proteins, and alkaloids. The green synthesized AgNPs (ML-AgNPs) were characterized by UV–vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission emission microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and Energy dispersive X-ray analysis (EDX). Thermo gravimetric analysis (TGA) was performed on the synthesized ML-capped AgNPs to determine the thermal stability and the formation of the green synthesized AgNPs. The formation of AgNPs was confirmed by the UV–vis absorption spectra, which showed an absorption band at 420 nm. The morphology of ML extract-mediated AgNPs was mostly spherical and rough-edged crystallite nanostructures, with an average particle size of 11 nm. The FTIR analyses revealed distinctive functional groups which were directly involved in the synthesis and stability of AgNPs. The crystallite size was 8.79 nm, with four intense peaks at 2 θ angles of 38°, 44°, 64°, and 77°. At an energy level of 3.4 keV, a significant signal was observed indicating the production of thermally stable and pure crystallite AgNPs. The antioxidant property of green synthesized ML-AgNPs was determined to be 40% higher than that of crude M. lucida leaf extract. The ability of green synthesized ML-AgNPs to scavenge free radicals also increased in the order of OH − < NO < H 2 O 2 . The ML-AgNPs have strong activities with a maximum against P. vulgaris and a minimum with E. faecalis.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

2022

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“…The concept of composable µPADs [32] was applied in this study to develop a method for the determination of dihydroquercetin. This concept implies designing a microfluidic system of a certain architecture for solving a particular analytical problem from ready-made elements that are fixed on an adhesive substrate.…”

Section: Resultsmentioning

confidence: 99%

“…At the same time, the variety of emerging practical problems stimulates the search for options of simple optimization of the analytical system architecture for a specific analysis, which, in our opinion, can be implemented by combining its separate, pre-produced parts. This idea has found its implementation in a concept of composable paper-based analytical devices, which can be assembled in a required architecture using several pre-made paper parts [32].…”

Section: Introductionmentioning

confidence: 99%

A Three-Reagent “Green” Paper-Based Analytical Device for Solid-Phase Spectrometric and Colorimetric Determination of Dihydroquercetin

Apyari

Furletov

Kalinin

et al. 2022

Sensors

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Microfluidic paper-based analytical devices (µPADs) represent one of the promising green analytical strategies for low-cost and simple determination of various analytes. The actual task is the development of such devices for quantitation of antioxidants, e.g., flavonoids. In this paper, possibilities of a novel three-reagent µPAD including silver nitrate, 4-nitrophenyldiazonium tetrafluoroborate, and iron(III) chloride as reagents are assessed with respect to the determination of dihydroquercetin. It is shown that all the three reagents produce different colorimetric responses that can be detected by a mini-spectrophotometer–monitor calibrator or by a smartphone. The method is applicable to direct measuring high contents of dihydroquercetin (the linearity range is 0.026–1 mg mL−1, and the limit of detection is 7.7 µg mL−1), which is favorable for many dietary supplements. The analysis of a food supplement was possible with the relative standard deviations of 9–26%, which is satisfactory for quantitative and semiquantitative determinations. It was found that plotting a calibration graph in 3D space of the three reagents’ responses allows us to distinguish dihydroquercetin from its close structural analogue, quercetin.

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“…Consequently, they can be considered as an important factor to be estimated in agriculture and food manufacturing, since their content strongly depends on the quality of fruits and plants [ 1 ]. Furthermore, bioflavonoids exhibit a vast spectrum of biological activity and have a direct impact on the functioning of living organisms [ 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Fast and Sensitive Determination of Bioflavonoids Using a New Analytical System Based on Label-Free Silver Triangular Nanoplates

Furletov

Apyari

Гаршев

et al. 2022

Sensors

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Optical sensors based on silver triangular nanoplates (AgTNPs) are insufficiently studied as probes for the spectrophotometric determination of biologically active compounds. In the present article, an interaction between label-free AgTNPs and bioflavonoids in the presence of silver(I) ions was assessed to outline the possibilities of AgTNPs as a colorimetric probe for the fast and sensitive determination of bioflavonoids. It is shown that the interaction was accompanied by a bathochromic shift of the local surface plasmon resonance band of nanoparticles and an increase in its intensity. Seven bioflavonoids differing in their structure were tested. The influence of the structure of analytes and the main external factors on the analytical signal is discussed in detail. It was found that the detection limits of bioflavonoids in the selected optimal conditions increased in the series morin < rutin = quercetin < taxifolin and came to 0.9, 1.2, 1.2, and 2.0 μmol·L−1, respectively. Chrysin, naringenin, and naringin were found not to affect the spectral characteristics of AgTNPs. The suggested approach was applied for the spectrophotometric determination of flavonoids in pharmaceuticals and onion peel.

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Composable paper-based analytical devices for determination of flavonoids

Cited by 14 publications

References 60 publications

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

A Three-Reagent “Green” Paper-Based Analytical Device for Solid-Phase Spectrometric and Colorimetric Determination of Dihydroquercetin

Fast and Sensitive Determination of Bioflavonoids Using a New Analytical System Based on Label-Free Silver Triangular Nanoplates

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