Components of schizophrenia liability affect the growth of psychological stress sensitivity following major life events

Grattan, Rebecca E.; Linscott, Richard J.

doi:10.1016/j.schres.2019.07.056

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…We now demonstrated that schizotypal traits might engender vulnerability for hoarding symptoms, particularly in relation to the COVID-19 pandemic. These findings are also consistent with schizotypal traits conferring greater vulnerability to stress ( Grattan and Linscott, 2019 ; Walter et al, 2018 ).…”

Section: Discussionsupporting

confidence: 81%

Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic

Fontenelle

Albertella

Brierley

et al. 2021

Journal of Psychiatric Research

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Section: Discussionsupporting

confidence: 81%

Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic

Fontenelle

Albertella

Brierley

et al. 2021

Journal of Psychiatric Research

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“…The results indicated that stressful life events were related to relapse in schizophrenia, which is consistent with our initial hypothesis. This was also consistent with previous studies, which reported that stressful life events in patients' daily lives were associated with relapse [43,44]. We also found that subjective social support, objective social support, and availability were all related to relapse.…”

Section: Discussionsupporting

confidence: 93%

Stressful life events and relapse in schizophrenia: The moderating effect of social support

Liu

Zhu

Wang³

et al. 2022

Preprint

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Purpose: This study aimed to explore the relationship between stressful life events, relapse, and social support, and the moderating effect of social support on the association between stressful life events and relapse in schizophrenia.Methods: A descriptive cross-sectional study was performed on 215 patients recruited from Ningxia Mental Health Centre, China. All participants completed the Social Readjustment Rating Scale, Social Support Rating Scale, Brief Psychiatric Rating Scale, Clinical Global Impressions-Severity Scale, and Morisky Medication Adherence Scales-8. Spearman’s correlation analysis and binary logistic regression analysis were used to explore the relationship between stressful life events, relapse, and social support. The moderating effect of social support was tested with PROCESS 3.4 SPSS.Results: Stressful life events and the three domains of social support exerted a significant influence on the relapse of schizophrenia. Significant evidence suggests that social support acts as a protective factor and moderates the relationship between stressful life events and relapse. However, this moderating effect exists only in subjective social support and not in objective social support and availability.Conclusion: This study provides a better understanding of the relationship between stressful life events, relapse, and social support and provides significant evidence suggesting that social support moderates the impact of stressful life events on relapse. This suggests that the promotion of social support is beneficial in reducing the risk of relapse in patients with schizophrenia.

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“…Seven of the studies investigated the link between subclinical psychotic experiences and stress reactivity in the general population. All seven studies demonstrated a positive association between levels of stress sensitivity and psychotic‐like experiences, effect sizes range from medium to high (DeVylder & Hilimire, 2015; Gibson et al, 2014; Gibson et al, 2019; Grattan & Linscott, 2019; Laloyaux et al, 2016; Rössler et al, 2016; Ruzibiza et al, 2018). This suggests that higher levels of subclinical psychotic‐like experiences are associated with greater stress sensitivity.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta‐analysis of the association between emotional stress reactivity and psychosis

Muddle

Jones

Taylor

et al. 2021

Early Intervention Psych

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Aim Emotional stress reactivity may be a mediating factor in the association between trauma and psychosis. This review aimed to (i) identify, summarise and critically evaluate the link between emotional stress reactivity and psychotic experiences (ii) examine evidence for a 'dose–response' relationship between stress reactivity and psychosis in the wider psychosis phenotype (i.e., sub‐clinical symptoms). Methods Electronic database searches (PsychINFO, MEDLINE, EMBASE) were conducted for studies which investigated the link between stress reactivity and psychosis, psychotic symptoms, or a vulnerability to developing psychosis (wider phenotype). Cross‐sectional, experimental and experience sampling method study designs were eligible for inclusion. Results Fourty five eligible articles were identified (N participants = 8830). Narrative synthesis showed that increased emotional stress reactivity was associated with psychosis and subclinical psychotic experiences across all study designs, however, findings were inconsistent across studies. The preliminary meta‐analysis (k = 4, n = 383) showed increases in emotional stress reactivity was associated with higher negative affect in response to event‐related stress, in those with psychosis compared to controls (mean difference in beta coefficients = 0.05, 95% CI 0.02–0.08, p = .004). However, this difference was small with a considerable degree of heterogeneity (p = .001, I2 = 81%) so results should be interpreted with caution. Conclusions Overall, the evidence suggests that there is a link between emotional stress reactivity and psychosis in those with psychosis, those at high risk of developing psychosis and in relation to subclinical psychotic‐like experiences in the general population.

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Components of schizophrenia liability affect the growth of psychological stress sensitivity following major life events

Cited by 16 publications

References 40 publications

Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic

Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic

Stressful life events and relapse in schizophrenia: The moderating effect of social support

A systematic review and meta‐analysis of the association between emotional stress reactivity and psychosis

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