Abstract:El objetivo de este estudio fue evaluar el contenido de componentes bioactivos, actividad antioxidante y relación ácidos clorogénicos/cafeína de 34 cafés comerciales de Panamá. Se identificaron y cuantificaron diez compuestos bioactivos del extracto acuoso de café por cromatografía líquida de alta resolución y se determinó la actividad antioxidante por el método del radical 2,2´-azino-bis-(3-etilbenzotiazolina-6-sulfónico). Los componentes bioactivos determinados fueron: los ácidos 3-cafeoilquínico, 4-cafeoilq… Show more
“…The smallest range of the caffeine/CGAs ratio was found in instant coffee sold in the United Kingdom, and the largest was in espresso coffee in the United Kingdom. In contrast to these results for coffee drinks, the study by Vega et al [39], which determined the amounts of caffeine and total CGAs in roasted coffee beans and calculated the caffeine/CGAs ratio, reported the smallest values, from 0.2 to 9.2.Fig. 3The mean value of the caffeine/CGAs ratios of the nine sub-groups.…”
“…The smallest range of the caffeine/CGAs ratio was found in instant coffee sold in the United Kingdom, and the largest was in espresso coffee in the United Kingdom. In contrast to these results for coffee drinks, the study by Vega et al [39], which determined the amounts of caffeine and total CGAs in roasted coffee beans and calculated the caffeine/CGAs ratio, reported the smallest values, from 0.2 to 9.2.Fig. 3The mean value of the caffeine/CGAs ratios of the nine sub-groups.…”
“…A toxicidade dos oligômeros e agregados foi diminuída, com redução concomitante do estresse oxidativo intracelular, dano oxidativo ao proteoma e aumento da sobrevivência celular 25 . Isso pode se explicar pela capacidade da cafeína, enquanto composto fenólico, de abstrair elétrons do meio e evitar a oxidação das biomoléculas 27 .…”
Section: Autor Ano Objetivo Tipo De Estudo Principais Resultadosunclassified
I
Introdução: No mundo, estima-se que a doença de Parkinson (DP) seja a segunda neuropatologia degenerativa mais comum, sendo precedida apenas pelo mal de Alzheimer. Trata-se de uma doença idiopática, que resulta das interações individuais com fatores ambientais e que acarreta disfunções bioquímicas. Sabe-se, entretanto, que metilxantinas, como a cafeína, possuem atividades biológicas que estão correlacionadas com a fisiopatologia das demências. Objetivo: Verificar a atividade profilática da cafeína no controle da DP. Métodos: Foi realizada uma revisão de literatura com busca eletrônica de artigos científicos, publicados entre 2015 e 2020, nas bases Scientific Eletronic Library (SciELO), Centro Latino-americano e do Caribe de Informação em Ciências da Saúde (BIREME-OPAS-OMS) e National Library of Medicine, dos EUA (PubMed). A busca se deu a partir da pesquisa das palavras-chave “caffeine and Parkinson disease”. Resultados: Foram selecionados dez artigos, dos quais cinco sugeriram que a cafeína possui potencial terapêutico no tratamento da DP em modelo animal; dois indicaram que, in vitro, a cafeína possui potencial terapêutico; três não correlacionaram a cafeína com melhora clínica da DP, em caso de doença já estabelecida em humanos; dois indicaram o consumo da cafeína como fator protetor ao desenvolvimento da DP. Conclusão: A cafeína possui atividade antiparkinsoniana in vitro e in vivo. Entretanto, esse efeito não se reproduz em ensaios clínicos, o que indica ineficácia translacional. Contudo, ainda se faz necessário mais estudos clínicos multicêntricos, com a cafeína isolada, que visem à averiguação da utilidade, ou não, como terapia adjuvante no tratamento da DP.
“…Porophyllum ruderale is a great source of phenolic compounds with important antiinflammatory and antioxidant activities that can contribute to its nephroprotective effect. For example, chlorogenic acid has antioxidant activity and protects cells from oxidative stress [60]; in addition, it is able to inhibit nitric oxide production by macrophages and suppress T cell proliferation, decreasing inflammatory processes [61]. While, ferulic acid has a potent antioxidant activity mediated mainly by its binding to free radicals to donate hydrogen molecules, as well as inhibit superoxide anion [62][63][64][65][66].…”
Acute kidney injury and impaired kidney function is associated with reduced survival and increased morbidity. Porophyllum ruderale is an edible plant endemic to Mexico used in Mexican traditional medicine. The aim of this study was to evaluate the nephroprotective effect of a hydroalcoholic extract (MeOH:water 70:30, v/v) from the aerial parts of P. ruderale (HEPr). Firstly, in vitro the antioxidant and anti-inflammatory activity of HEPr was determined; after the in vivo nephroprotective activity of HEPr was evaluated using a thioacetamide-induced injury model in rats. HEPr showed a slight effect on LPS-NO production in macrophages (15% INO at 40 µg/mL) and high antioxidant activity in the ferric reducing antioxidant power (FRAP) test, followed by the activity on DPPH and ABTS radicals test (69.04, 63.06 and 32.96% of inhibition, respectively). In addition, values of kidney injury biomarkers in urine (urobilinogen, hemoglobin, bilirubin, ketones, glucose, protein, pH, nitrites, leukocytes, specific gravity, and the microalbumin/creatinine) and serum (creatinine, urea, and urea nitrogen) of rats treated with HEPr were maintained in normal ranges. Finally, 5-O-caffeoylquinic, 4-O-caffeoylquinic and ferulic acids; as well as 3-O-quercetin glucoside and 3-O-kaempferol glucoside were identified by HPLC as major components of HEPr. In conclusion, Porophyllum ruderale constitutes a source of compounds for the treatment of acute kidney injury.
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