Component-specific effects of physostigmine on the cat visual evoked potential

Arakawa, Kenji; Peachey, Neal S.; Celesia, Gastone G.; Rubboli, Guido

doi:10.1007/bf00229785

Cited by 26 publications

(14 citation statements)

References 19 publications

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“…In the superior colliculus of rats treated with 0.4 mg/kg of PHY, Hetzler and Melk [51] confirmed that the amplitudes of P1 and P3 components were depressed and the P4 component was enhanced. These results support the hypothesis that each VEP component may be modulated in its own way, depending on the drug, the dose, the animal model and the recording techniques [50].…”

Section: Discussionsupporting

confidence: 78%

“…After 1 mg/kg of PHY in rats, an amplitude reduction in the middle component and an increase in the first component was shown [46]. 0.4 mg/kg of PHY in the rat at f-VEP [47,48] and 0.8 mg/kg in the cat at pattern reversal VEPs [49] suppressed all amplitude component; on the other hand, after 1 mg/kg Arakawa et al [50] showed only a reduction in the P1N1 component. In the superior colliculus of rats treated with 0.4 mg/kg of PHY, Hetzler and Melk [51] confirmed that the amplitudes of P1 and P3 components were depressed and the P4 component was enhanced.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Cholinergic Drugs on Neocortical EEG and Flash-Visual Evoked Potentials in the Mouse

Tebano

Luzi²,

Palazzesi³

et al. 1999

Neuropsychobiology

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The effects of single intraperitoneal injection of two cholinesterase inhibitors, physostigmine (PHY; 0.01, 0.025, 0.05, 0.1, 0.2 mg/kg) and heptylphysostigmine (HEP; 0.5, 2, 6 mg/kg) on electroencephalographic (EEG) activity and flash visual evoked potentials (f-VEP) in the occipital cortex were compared in DBA/2 mice. EEG spectral analysis of awake periods showed that PHY at all doses and HEP at 2 mg/kg induced an increase of power in the 4.25- to 7-Hz frequency band. Furthermore, PHY at the higher doses and HEP at all doses induced a decrease of power in the 7.25- to 12-Hz frequency band, while the lower doses of PHY (0.01, 0.025 mg/kg) produced an increase of this band. EEG effects elicited by the two drugs were similar, when doses displaying analogous biochemical effects (acetylcholinesterase inhibition) were used (i.e. 0.01 and 0.025 mg/kg of PHY versus 0.5 and 2 mg/kg of HEP). PHY and HEP induced similar changes in f-VEPs. Amplitudes of early and late components (P1N1, N1P2, P4N4 and particularly N1P3) were enhanced, while amplitudes of middle components were depressed after all doses. The peak latency measures were generally delayed, even though, after the lower doses, a trend to a latency reduction was evident in late components. This finding might indicate a possible effect on stimulus speed diffusion by ‘low therapeutic’ doses, analogous to the ones used in men. Our data show that both drugs are effective in modifying EEG and f-VEP parameters connected with brain cholinergic function, although in a very narrow dose range.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Effects of Cholinergic Drugs on Neocortical EEG and Flash-Visual Evoked Potentials in the Mouse

Tebano

Luzi²,

Palazzesi³

et al. 1999

Neuropsychobiology

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“…The VEP latency, however, was modulated in an opposite way. Our results support the assumption that each VEP component may be modulated in its own way [17], The contradictory EEG and VEP changes after drug applica tion may be explained by different direct or indirect drug effects on the hippocampus (EEG) and on the occipital neocortex (VEP). However, further experiments with si multaneous EEG records within the dorsal hippocampus and the occipital neocortex are necessary to separate the participation of both regions in the generation of the oc cipital electrocorticogram.…”

Section: Discussionsupporting

confidence: 76%

Behavior-Dependent and Drug-Induced Changes of Rat Visual Evoked Potential: Relation to the EEG Spectral Power

Bringmann

Klingberg²

1995

Neuropsychobiology

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The relation between EEG spectral power and alterations of the visual evoked potential (VEP) during different behavioral states and after intraperitoneal application of neuroactive drugs have been investigated in Long-Evans rats. FFT power and field potential maps were made in five behavioral states of the unrestrained rat: exploratory sniffing, face washing, relaxed waking immobility, slow wave sleep, and during cortical high-voltage spindling. Fourteen epidural electrodes were implanted in the bulbus olfactorius, in the frontal areas Fr2 and Fr1, in the visual areas 18 and 17, and in the cerebellum of the right hemisphere. Two regions in the investigated cortex were found to be the probable origins of slow delta and theta waves: the frontal cortex and the anterior area 18. Area 17 does not express prominent EEG frequencies that contribute to the cortical EEG in any of the investigated behavioral states. The VEP was found to originate in area 17. The neural activity of the occipital cortex is reflected in the VEP whereas the occipital EEG possibly reflects the hippocampal activity in some behavioral states. This may be a reason for partly independent changes of VEP and EEG during different behavioral states and after application of neuroactive drugs.

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“…Such response characteristics respectively follow the known contrast response functions of the parvocellular and magnocellular pathways to sinusoidal luminance gratings (Benardete et al 1992;Benardete and Kaplan 1997a,b;Derrington and Lennie 1984;Merigan and Eskin 1986;Merigan and Maunsell 1993;Tootell et al 1988). Additionally, both C1 and P1 components have been shown to be pharmacologically separable in the cat visual cortex (e.g., Arakawa et al 1993;Zemon et al 1980) and are differentially modulated by cathodal or anodal stimulation in transcranial direct current stimulation (tDCS) paradigms with human participants (Accornero et al 2007;Antal et al 2004). The pharmacological separability of the C1 and P1 VEP components in cats and differential modulation of the same components in humans using tDCS would both be expected if each component were generated by different neural populations.…”

mentioning

confidence: 56%

Different spatial frequency bands selectively signal for natural image statistics in the early visual system

Hansen

Johnson

Ellemberg

2012

Journal of Neurophysiology

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Hansen BC, Johnson AP, Ellemberg D. Different spatial frequency bands selectively signal for natural image statistics in the early visual system. J Neurophysiol 108: 2160 -2172, 2012. First published July 25, 2012 doi:10.1152/jn.00288.2012.-Early visual evoked potentials (VEPs) measured in humans have recently been observed to be modulated by the image statistics of natural scene imagery. Specifically, the early VEP is dominated by a strong positivity when participants view minimally complex natural scene imagery, with the magnitude of that component being modulated by luminance contrast differences across spatial frequency (i.e., the slope of the amplitude spectrum). For scenes high in structural complexity, the early VEP is dominated by a prominent negativity that exhibits little dependency on luminance contrast. However, since natural scene imagery is broad band in terms of spatial frequency, it is not known whether the above-mentioned modulation results from a complex interaction within or between the early neural processes tuned to different bands of spatial frequency. Here, we sought to address this question by measuring early VEPs (specifically, the C1, P1, and N1 components) while human participants viewed natural scene imagery that was filtered to contain specific bands of spatial frequency information. The results show that the C1 component is largely unmodulated by the luminance statistics of natural scene imagery (being only measurable when such stimuli were made to contain high spatial frequencies). The P1 and N1, on the other hand, were observed to exhibit strong spatial frequency-dependent modulation to the luminance statistics of natural scene imagery. The results therefore suggest that the dependency of early VEPs on natural image statistics results from an interaction between the early neural processes tuned to different bands of spatial frequency.

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Component-specific effects of physostigmine on the cat visual evoked potential

Cited by 26 publications

References 19 publications

Effects of Cholinergic Drugs on Neocortical EEG and Flash-Visual Evoked Potentials in the Mouse

Effects of Cholinergic Drugs on Neocortical EEG and Flash-Visual Evoked Potentials in the Mouse

Behavior-Dependent and Drug-Induced Changes of Rat Visual Evoked Potential: Relation to the EEG Spectral Power

Different spatial frequency bands selectively signal for natural image statistics in the early visual system

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