Component of<i>Zingiber officinale</i>that Improves the Enhancement of Small Intestinal Transport

Hashimoto, Kazunori; Satoh, Kaneo; Murata, Pin; Makino, Bunsho; Sakakibara, Iwao; Kase, Yoshio; Ishige, Atsushi; Higuchi, Masahiko; Sasaki, Hiroshi

doi:10.1055/s-2002-34928

Cited by 19 publications

(11 citation statements)

References 5 publications

(8 reference statements)

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“…[6]-Shogaol was shown, among other effects, to have a central nervous system-suppressing effect [3], an effect on arachidonic acid metabolism [4], a prostaglandin formation-inhibiting effect [5], a small intestine blood flowincreasing effect [6], a small intestine peristaltic motionpromoting effect [7]. Its main metabolite [6]-paradol was also shown to have a bactericidal effect [8] and activator protein 1 activity [9].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

et al. 2010

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To investigate the pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe, the pharmacokinetic parameters were determined by using (14)C-[6]-shogaol (labeled compound) and [6]-shogaol (non-labeled compound). When the labeled compound was orally administered to rats, the maximum plasma concentration (C (max)) and the area under the curve (AUC) of plasma radioactivity concentration increased in a dose-dependent manner. When the labeled compound was orally administered at a dose of 10 mg/kg, 20.0 + or - 1.8% of the radioactivity administered was excreted into urine, 64.0 + or - 12.9% into feces, and 0.2 + or - 0.1% into breath. Thus, more of the radioactivity was excreted into feces than into urine, and almost no radioactivity was excreted into breath. Furthermore, when the labeled compound was orally administered at a dose of 10 mg/kg, cumulative biliary radioactivity excretion over 48 h was 78.5 + or - 4.5% of the radioactivity administered, and cumulative urinary radioactivity excretion over 48 h was 11.8 + or - 2.7%, showing that about 90% of the dose administered orally was absorbed from the digestive tract and most of the fecal excretion was via biliary excretion. On the other hand, when the non-labeled compound [6]-shogaol was orally administered, the plasma concentration and biliary excretion of the unchanged form were extremely low. When these results are combined with those obtained with the labeled compound, it would suggest that [6]-shogaol is mostly metabolized in the body and excreted as metabolites.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

et al. 2010

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“…Other constituents include volatile oil, aryl alkanes, shogaols, diarylheptanoids and starch (Gruenwald et al, 2000). Isolated gingerols and shogaols have been shown to affect gastric motility in animal experiments (Hashimoto et al, 2002;Suekawa et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro

et al. 2004

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“…In addition, the participants refrained from Japanese pepper-, ginseng-, and gingercontaining foods for 3 days before the study until completion of the study. (Bautista et al, 2008) Ginger Shogaols, gingerols Antiemetic effect (Kawai et al, 1994) TRPV1 stimulation (Iwasaki et al, 2006) Prokinetic effect (Ghayur and Gilani, 2006) Inhibition of Ca 2ϩ channels (Ghayur et al, 2008) Relax muscle (Hashimoto et al, 2002) 5-HT3 receptor blocking (Abdel-Aziz et al, 2005) Increase intestinal blood flow (Murata et al, 2002) Anti-inflammatory effect (Pan et al, 2008) Ginseng Ginsenosides Alleviation of noxious pain (Kim et al, 2005) TRPV1 modulation (Jung et al, 2001) Anti-inflammatory effect Modulation of Ca 2ϩ channels (Rhim et al, 2002) Amelioration of accelerated intestinal transit (Hashimoto et al, 2003) Inhibition of various ion-gated channels (Nah et al, 2007) Blood samples (20 ml each) were collected from the medial cubital vein into evacuated tubes containing heparin just before and at 0.5, 1, 2, 4, and 8 h after administration and were immediately centrifuged (3000 rpm, 15 min). Urine samples (50 ml each) were collected the day before the administration and at 0 to 4 h and 4 to 8 h after administration.…”

Section: Chemicals Andmentioning

confidence: 99%

Profiling of the Compounds Absorbed in Human Plasma and Urine after Oral Administration of a Traditional Japanese (Kampo) Medicine, Daikenchuto

Iwabu¹,

Watanabe²,

Hirakura³

et al. 2010

Drug Metab Dispos

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ABSTRACT:Daikenchuto (DKT), a pharmaceutical-grade traditional Japanese (Kampo) medicine, has been widely used for the treatment of various gastrointestinal disorders including postoperative ileus and has been integrated into the modern medical care system in Japan as a prescription drug. DKT is a multiherbal medicine consisting of Japanese pepper (zanthoxylum fruit), processed ginger, and ginseng with maltose as an additive. Despite substantial research on the pharmacological activities of DKT and its ingredients, the lack of studies on absorption, distribution, metabolism, and excretion of DKT has made it difficult to obtain a consistent picture of its mechanism of action. In the present study, we constructed an analysis procedure consisting of seven conditions of liquid chromatography and mass spectrometric analysis, which enabled the identification of 44 ingredients of DKT component herbs. We investigated the plasma and urine profiles of these ingredients 0.5 to 8 h after oral administration of 15.0 g of DKT in four healthy volunteers. The results indicated that 1) hydroxy-␣-sanshool and [6]-shogaol, the prominent peaks in plasma derived from Japanese pepper and ginger, respectively, were detected at 0.5 h and thereafter decreased throughout the sampling period; 2) ginsenoside Rb 1 , a prominent peak derived from ginseng, increased gradually during the sampling period; 3) glucuronide conjugates of hydroxy-sanshools, shogaols, and gingerols were detected in plasma and urine; and 4) no obvious differences between samples from the two male and the two female individuals were observed. These results provide a strong basis for future studies on pharmacokinetics and pharmacology of DKT.

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Component ofZingiber officinalethat Improves the Enhancement of Small Intestinal Transport

Cited by 19 publications

References 5 publications

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro

Profiling of the Compounds Absorbed in Human Plasma and Urine after Oral Administration of a Traditional Japanese (Kampo) Medicine, Daikenchuto

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