Component and morphology biases on quantifying the composition of nanoparticles using single-particle mass spectrometry

Zhou, Lei; Rai, A.; Zachariah, Michael R.

doi:10.1016/j.ijms.2006.07.006

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…To obtain the mass concentrations of individual species from SPMS data, ionization efficiencies must be corrected for using relative sensitivity factors derived in lab calibration studies (Gross et al, 2000). The impacts of particle matrix and morphology on ionization have been examined recently by SPMS (Cai, Zelenyuk, & Imre, 2006; Zhou, Rai, & Zachariah, 2006b). Spatial inhomogeneities in the LDI beam impact ion signal reproducibility; however, these variations are reduced substantially by homogenizing the beam, such as with an optical fiber (Wenzel & Prather, 2004).…”

Section: On‐line Mass Spectrometrymentioning

confidence: 99%

Mass spectrometry of atmospheric aerosols—Recent developments and applications. Part II: On‐line mass spectrometry techniques

Pratt

Prather

2011

Mass Spectrometry Reviews

232

178

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Many of the significant advances in our understanding of atmospheric particles can be attributed to the application of mass spectrometry. Mass spectrometry provides high sensitivity with fast response time to probe chemically complex particles. This review focuses on recent developments and applications in the field of mass spectrometry of atmospheric aerosols. In Part II of this two-part review, we concentrate on real-time mass spectrometry techniques, which provide high time resolution for insight into brief events and diurnal changes while eliminating the potential artifacts acquired during long-term filter sampling. In particular, real-time mass spectrometry has been shown recently to provide the ability to probe the chemical composition of ambient individual particles <30 nm in diameter to further our understanding of how particles are formed through nucleation in the atmosphere. Further, transportable real-time mass spectrometry techniques are now used frequently on ground-, ship-, and aircraft-based studies around the globe to further our understanding of the spatial distribution of atmospheric aerosols. In addition, coupling aerosol mass spectrometry techniques with other measurements in series has allowed the in situ determination of chemically resolved particle effective density, refractive index, volatility, and cloud activation properties.

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Section: On‐line Mass Spectrometrymentioning

confidence: 99%

Mass spectrometry of atmospheric aerosols—Recent developments and applications. Part II: On‐line mass spectrometry techniques

Pratt

Prather

2011

Mass Spectrometry Reviews

232

178

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“…Composition measurements with SPMS are usually considered qualitative due to shot-to-shot variations in instrument function and a strong matrix effect that influences the ionisation process (Reilly et al, 2000;Zhou et al, 2006;Reinard and Johnston, 2008). These phenomena result in ion signals that are not proportional to the mass of the chemical species and a particle number counting bias with respect to particle type.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the influence of laser wavelength and detection stage geometry on optical detection efficiency in a single-particle mass spectrometer

et al. 2016

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Abstract. Single-particle mass spectrometry (SPMS) is a useful tool for the online study of aerosols with the ability to measure size-resolved chemical composition with a temporal resolution relevant to atmospheric processes. In SPMS, optical particle detection is used for the effective temporal alignment of an ablation laser pulse with the presence of a particle in the ion source, and it gives the option of aerodynamic sizing by measuring the offset of particle arrival times between two detection stages. The efficiency of the optical detection stage has a strong influence on the overall instrument performance.A custom detection laser system consisting of a highpowered fibre-coupled Nd:YAG solid-state laser with a collimated beam was implemented in the detection stage of a laser ablation aerosol particle time-of-flight (LAAP-TOF) singleparticle mass spectrometer without major modifications to instrument geometry. The use of a collimated laser beam permitted the construction of a numerical model that predicts the effects of detection laser wavelength, output power, beam focussing characteristics, light collection angle, particle size, and refractive index on the effective detection radius (R) of the detection laser beam. We compare the model predictions with an ambient data set acquired during the Ice in Clouds Experiment -Dust (ICE-D) project.The new laser system resulted in an order-of-magnitude improvement in instrument sensitivity to spherical particles in the size range 500-800 nm compared to a focussed 405 nm laser diode system. The model demonstrates that the limit of detection in terms of particle size is determined by the scattering cross section (C sca ) as predicted by Mie theory. In addition, if light is collected over a narrow collection angle, oscillations in the magnitude of C sca with respect to particle diameter result in a variation in R, resulting in large particlesize-dependent variation in detection efficiency across the particle transmission range. This detection bias is imposed on the aerodynamic size distributions measured by the instrument and accounts for some of the detection bias towards sea salt particles in the ambient data set.

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“…A reduction of such matrix effects can be achieved by separating the desorption and ionization process using a combination of a desorption (often infrared) laser and a UV laser 75, 97–99. Application of high irradiances of 10 10 W/cm 2 to 10 11 W/cm 2 completely vapourizes the particles and atoms are mostly converted to positively charged ions and electrons 100–102. This method improves atomic quantification at the cost of information of molecular particle components.…”

Section: Instrumentation—state Of the Artmentioning

confidence: 99%

“…Thermodynamic calculations of the ion production rate are difficult because of many (mostly unknown) multi‐factorial parameters 47, 102. Reliable quantitative predictions for individual components in single ambient particles are therefore not possible 75.…”

Section: Instrumentation—state Of the Artmentioning

confidence: 99%

Instrumentation, data evaluation and quantification in on‐line aerosol mass spectrometry

Hinz

Spengler

2007

J. Mass Spectrom.

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On-line micro-and nanoparticle mass spectrometry has evolved into a prominent analytical method for the characterization of airborne particles, particle populations and aerosols over the recent years, driven by essential developments in instrumentation, data evaluation and validation. In this tutorial, the fundamental aspects of the technology and methodology for qualitative and quantitative on-line aerosol particle analysis are discussed. Specific properties of the on-line mass spectrometric instrumentation for particle analysis are described, combined with a discussion of basic differences of the instruments and demands for future improvements of instruments and data analysis techniques. Optimized technology and methodology in particle analysis is expected to lead to essential growth of the knowledge and to quality improvement of the description of atmospheric processes and health effects in the future.

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Component and morphology biases on quantifying the composition of nanoparticles using single-particle mass spectrometry

Cited by 9 publications

References 26 publications

Mass spectrometry of atmospheric aerosols—Recent developments and applications. Part II: On‐line mass spectrometry techniques

Mass spectrometry of atmospheric aerosols—Recent developments and applications. Part II: On‐line mass spectrometry techniques

Evaluating the influence of laser wavelength and detection stage geometry on optical detection efficiency in a single-particle mass spectrometer

Instrumentation, data evaluation and quantification in on‐line aerosol mass spectrometry

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