Complications, Urinary Continence, and Oncologic Outcome of 1000 Laparoscopic Transperitoneal Radical Prostatectomies—Experience at the Charité Hospital Berlin, Campus Mitte

Lein, Michael; Stibane, Inna; Mansour, Ramin; Hege, Claudia; Roigas, Jan; Wille, Andreas; Jung, Klaus; Kristiansen, Glen; Schnorr, Dietmar; Loening, Stefan A.; Değer, Serdar

doi:10.1016/j.eururo.2006.06.023

Cited by 94 publications

(64 citation statements)

References 30 publications

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“…First, number of patients with biochemical relapse was relatively small, but corresponded to the failure rate generally observed. 23,24 Nevertheless, the prognostic value of Gleason score and pT stage could be reproduced indicating representativeness of our cohort. Further, recurrence-free interval after radical prostatectomy was significantly decreased with increasing hsa-miR-96 expression and that was confirmed in an independent second patient set.…”

Section: Discussionmentioning

confidence: 99%

“…Considering a proportional difference of about 0.40 in Kaplan-Meier curves as observed in patients after radical prostatectomy depending on the main risk factors Gleason score and tumor stage 23,24 about 25 subjects in each group have to be investigated. We decided to study at least 70 patients in the followup to realize a power of at least 80%, because the sample size between the groups of tumor recurrence or no recurrence could not be predicted.…”

Section: Data Analysis and Statistical Methodsmentioning

confidence: 99%

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Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma

Schaefer

Jung

Mollenkopf

et al. 2009

Intl Journal of Cancer

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505

491

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This study aimed to investigate the microRNA (miRNA) profile in prostate carcinoma tissue by microarray analysis and RT-qPCR, to clarify associations of miRNA expression with clinicopathologic data and to evaluate the potential of miRNAs as diagnostic and prognostic markers. Matched tumor and adjacent normal tissues were obtained from 76 radical prostatectomy specimens. Twenty-four tissue pairs were analyzed using human miRNA microarrays for 470 human miRNAs. Differentially expressed miRNAs were validated by TaqMan RT-qPCR using all 76 tissue pairs. The diagnostic potential of miRNAs was calculated by receiver operating characteristics analyses. The prognostic value was assessed in terms of biochemical recurrence using Kaplan-Meier and Cox regression analyses. Fifteen differentially expressed miRNAs were identified with concordant fold-changes by microarray and RT-qPCR analyses. Ten microRNAs (hsa-miR-16, hsa-miR-31, hsa-miR-125b, hsamiR-145, hsa-miR-149, hsa-miR-181b, hsa-miR-184, hsa-miR-205, hsa-miR-221, hsa-miR-222) were downregulated and 5 miRNAs (hsa-miR-96, hsa-miR-182, hsa-miR-182*, hsa-miR-183, hsa-375) were upregulated. Expression of 5 miRNAs correlated with Gleason score or pathological tumor stage. Already 2 microRNAs classified up to 84% of malignant and nonmalignant samples correctly. Expression of hsa-miR-96 was associated with cancer recurrence after radical prostatectomy and that prognostic information was confirmed by an independent tumor sample set from 79 patients. That was shown with hsa-miR-96 and the Gleason score as final variables in the Cox models build in the 2 patient sets investigated. Thus, differential miRNAs in prostate cancer are useful diagnostic and prognostic indicators. This study provides a solid basis for further functional analyses of miRNAs in prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Data Analysis and Statistical Methodsmentioning

confidence: 99%

Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma

Schaefer

Jung

Mollenkopf

et al. 2009

Intl Journal of Cancer

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505

491

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“…Two surgeons performed > 400, two peformed > 200 and four performed < 200 LRPs in this series. The operating technique is described elsewhere [ 2,5 ] . Preservation of the neurovascular bundle was performed as an interfascial dissection.…”

Section: Methodsmentioning

confidence: 99%

“…In 2006, our group published complications and early outcome results of the fi rst 1000 transperitoneal LRP cases [ 5 ] . Owing to its relative novelty, long-term outcome data for LRP are limited.…”

Section: Introductionmentioning

confidence: 99%

Long‐term oncological and continence outcomes after laparoscopic radical prostatectomy: a single‐centre experience

et al. 2012

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E 9 8 5What ' s known on the subject? and What does the study add? Over the past decade, minimally invasive laparoscopic radical prostatectomy and more recently robot-assisted laparoscopic prostatectomy have been introduced and have proven equally effective compared with open surgery in terms of mid-term cancer control and complication rates. Because long-term data is lacking, open prostatectomy is still considered the ' gold standard ' by some authors, who argue that minimally invasive approaches have to measure up to the excellent long-term results of open surgery.This study represents one of the largest series (1845 patients) of minimally invasive radical prostatectomy with extended follow-up (11.3 years) and detailed data on oncological outcome and postoperative incontinence. It therefore supplies previously lacking information on these details for minimally invasive prostate surgery and provides important information for patient counselling. OBJECTIVE• To investigate biochemical recurrence (BCR) rates and data on postoperative incontinence in a large laparoscopic radical prostatectomy (LRP) cohort with extended follow-up. MATERIALS AND METHODS• BCR and independent predictors of BCR were identifi ed using Kaplan -Meier and Cox regression analysis of 1845 patients who underwent LRP from 1999 to 2007.• Urinary incontinence was evaluated by pads per day and stratifi ed as follows: 0 -1 pad: no incontinence; 2 -3 pads: mild incontinence; and ≥ 3 pads: severe incontinence. RESULTS• Organ-confi ned disease, extraprostatic extension, seminal vesicle invasion and lymph node metastasis were present in 71.3%, 20.5%, 6.7% and 3.2% of patients, respectively. The positive surgical margin rate was 29.2%.• Postoperatively, 74.9% of the patients were continent, while 9.2% had mild and 15.9% severe incontinence.• The mean follow-up was 5 years with a maximum follow-up of 11.3 years.• There were 51 overall deaths and six deaths from prostate cancer. The 5-year, 8-year and 10-year BCR-free survival rates were 83.9%, 78.6% and 75.6%, respectively.• On univariate analyses preoperative D ' Amico risk classifi cation, pathological tumour stage, postoperative Gleason sum and surgical margin status were predictors of BCR ( P < 0.001).• On multivariable analysis, D ' Amico classifi cation, Gleason sum ( P < 0.001), postoperative tumour stage ( P < 0.001), nodal status ( P < 0.001) and surgical margin status ( P = 0.002) were independent predictors of BCR. CONCLUSIONS• LRP offers excellent long-term functional and oncological results with a low incidence of BCR for patients with localized disease.• These results could be used for patient counselling before robot-assisted laparascopic prostatectomy (RALP) until long-term follow-up data for RALP is available. KEYWORDSlaparoscopy , prostatectomy , localized prostate cancer , long-term outcome Study Type -Therapy (case series) Level of Evidence 4

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“…First, we did not investigate functional outcomes and perioperative complication rates associated with the three surgical techniques. However, this has been the subject of previous studies and was not the primary goal of the present study [21][22][23]. Second, follow-up for biochemical outcome was limited; extended follow-up was not available because of the relatively newer utilization of RARP for treatment of prostate cancer compared to RRP.…”

Section: Discussionmentioning

confidence: 95%

1003 Impact of Surgical Technique (Open vs. Laparoscopic vs. Robotic-Assisted) on Pathological and Biochemical Outcomes Following Radical Prostatectomy: An Analysis Using Propensity Score Matching

Magheli¹,

Gonzalgo²,

Su³

et al. 2011

European Urology Supplements

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Complications, Urinary Continence, and Oncologic Outcome of 1000 Laparoscopic Transperitoneal Radical Prostatectomies—Experience at the Charité Hospital Berlin, Campus Mitte

Cited by 94 publications

References 30 publications

Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma

Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma

Long‐term oncological and continence outcomes after laparoscopic radical prostatectomy: a single‐centre experience

1003 Impact of Surgical Technique (Open vs. Laparoscopic vs. Robotic-Assisted) on Pathological and Biochemical Outcomes Following Radical Prostatectomy: An Analysis Using Propensity Score Matching

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