Complications of Varicella in Unvaccinated Children From Romania, 2002–2013

Popescu, Corneliu Petru; Ceauşu, Emanoil; Florescu, Simin Aysel; Chirita, D; Ruță, Simona

doi:10.1097/inf.0000000000000969

Cited by 10 publications

(17 citation statements)

References 10 publications

(10 reference statements)

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“…In our research second most frequent complication were bacterial skin and soft tissue infections, occurred in 27.3% cases. Similar results were present by Almuneef et al -34% (11), but in some studies the frequency of secondary bacterial skin infections was lower and amounted from 8% to 10.4% (6,9,15). Gastrointestinal tract disorders were the third most common complication in our study (18,6%) and it was comparable to other results (15% -27.3%) (4,6,9,15).…”

Section: Discussionsupporting

confidence: 92%

“…One of the most common complications of pediatric chickenpox were respiratory tract infections, occurred in our study in 30.1% children. Our results were comparable with other studies, in which respiratory tract infections were reported in 26% to 32.3% children (6,9,12,15). In our research second most frequent complication were bacterial skin and soft tissue infections, occurred in 27.3% cases.…”

Section: Discussionsupporting

confidence: 92%

“…Our findings are also similar to the results of a 12year long survey from Lodz voivodeship, Polandcomplications diagnosed in children younger than one year of age constitute 15% and in children aged up to seven -71% (9). In Popescu et al study the highest rate of complications was recorded in the group age 0-1 year (48.9%), followed by 2-5 years (36.7%) (15).…”

Section: Discussionmentioning

confidence: 86%

“…In our research neurological complications constitutes 9.1% of all cases, with a predominance of acute cerebellar ataxia (53.6% of neurological complications). In the literature neurological complications were reported with a variable frequency from 4.6% to 38.2%, where cerebellar ataxia constituted from 3.1% to 64.5% of all cases (4,6,7,(9)(10)(11)(12)(13)15,16,17).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly in our study only 4.6% children were immunocompromised and no significant DYSKUSJA Dostępnych jest wiele aktualnych prac naukowych dotyczących ospy wietrznej u dzieci, częstości i rodzaju powikłań oraz rozpowszechnieniu i skuteczności szczepień. W analizowanym piśmiennictwie, podobnie jak w badaniu własnym, nie stwierdzono istotnej dominacji płci (6,(9)(10)(11)(12)(13)(14)(15)(16). Długość hospitalizacji w badaniach innych autorów wynosiła od 6,5 do 7 dni (6,7,9,10,13,15), natomiast w pracy własnej wynosiła 5 dni.…”

Section: Discussionunclassified

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Varicella complications in children one-site Polish population – a 19- year long survey

Smok

Franczak²,

Domagalski

et al. 2018

Przegl Epidemiol

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OBJECTIVES. The aim of this study was to describe the epidemiology of chickenpox complications in children, based on a 19-year long survey. METHODS. This publication constitutes a review of medical records of 761 patients under the age of 18 who were hospitalized at the T. Browicz Provincial Hospital for Infectious Diseases in Bydgoszcz, Poland from the 1st of January 1999 to the 31st of December 2017. RESULTS. Over the study period, 761 children diagnosed with varicella complications were hospitalized. The mean number of hospitalizations in each year amounted to 40. The median age of admitted patients was 4 years. The median length of hospitalization was 5 days (ranged from 1 to 30 days). The most frequent varicella complications included respiratory tract infections – 229/761 (30.1%), bacterial skin infections – 189/761 (24.8%) and gastrointestinal tract disorders – 142/761 (18.6%). Pneumonia, bronchitis and gastrointestinal tract disturbances, were reported most often in children under 2 years of age, while neurological complications occurred most frequently in children at 3-6 years of age. No significant differences in the number of varicella complications between immunocompromised and immunocompetent children were reported. CONCLUSIONS. Varicella complications mainly affect the youngest immunocompetent children. Population-wide vaccination and herd immunity appears to be the best way to reduce the incidence of chickenpox and the rate of varicella complications. This study gives support for inclusion of universal varicella vaccine in the National Immunization Program in Poland.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

See 3 more Smart Citations

Varicella complications in children one-site Polish population – a 19- year long survey

Smok

Franczak²,

Domagalski

et al. 2018

Przegl Epidemiol

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Specific Varicella-Related Complications and Their Decrease in Hospitalized Children after the Introduction of General Varicella Vaccination: Results from a Multicenter Pediatric Hospital Surveillance Study in Bavaria (Germany)

Hagemann

Krämer

Grote³

et al. 2019

Infect Dis Ther

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Background: Universal varicella vaccination (UVV) for children introduced in Germany in 2004 resulted in a significant overall decline of varicella-related hospitalizations (VRHs). We investigated the incidence of specific types of varicella-related complications (VRCs) in hospitalized children and the impact of UVV on VRCs during the first 7 years of UVV. Methods: Children\ 17 years of age hospitalized with an ICD-10-based (International Classification of Diseases, 10th Revision) discharge Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.9994730.

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Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis

Shah,

Meiwald,

Perera

et al. 2023

Infect Dis Ther

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Introduction Varicella (chickenpox) is an infectious disease caused by the varicella zoster virus affecting children, adolescents, and adults. Varicella symptoms are usually self-limiting; however, different complications with widespread and systemic manifestations can occur. This systematic literature review aims to explore and quantify varicella-associated complication rates. Methods Two databases (Embase and MEDLINE), congress abstracts, and reference lists of systematic reviews were screened to identify evidence on varicella complications. Complications were identified and grouped into 14 clinically relevant categories. Proportional meta-analyses were conducted using a random-effects model and tests for heterogeneity and publication bias were performed. Subgroup, sensitivity, and meta-regression analyses were also conducted. A total of 78 studies, spanning 30 countries, were included in the meta-analysis. Results Pooled prevalence was highest in severe varicella (22.42%; 95% confidence interval [CI] 10.13–37.77), skin-related complications (20.12%; 95% CI 15.48–25.20), and infection-related complications (10.03%; 95% CI 7.47–12.90). Cardiovascular (0.55%; 95% CI 0.08–1.33), genitourinary (1.17%; 95% CI 0.55–1.99), and musculoskeletal (1.54%; 95% CI 1.06–2.11) complications had the lowest pooled prevalence. The remaining complication categories ranged between 1% and 10%. Subgroup analysis showed that complications were more prevalent in children versus adults and in hospitalized patients versus outpatients. Meta-regression analysis found that no ecological level covariates were accurate predictors for the overall prevalence of varicella-associated complications. There was substantial heterogeneity and publication bias across all meta-analyses. Conclusion Results suggest that different types of varicella-associated complications could be frequent, impacting quality of life, and healthcare resource utilisation and budgets. These findings are crucial to raise awareness of the health and economic burden of varicella disease. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-023-00899-7.

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Complications of Varicella in Unvaccinated Children From Romania, 2002–2013

Cited by 10 publications

References 10 publications

Varicella complications in children one-site Polish population – a 19- year long survey

Varicella complications in children one-site Polish population – a 19- year long survey

Specific Varicella-Related Complications and Their Decrease in Hospitalized Children after the Introduction of General Varicella Vaccination: Results from a Multicenter Pediatric Hospital Surveillance Study in Bavaria (Germany)

Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis

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