Two methods of cardiac evaluation are presented. The first, the endocardial viability ratio, measures the relationship between oxygen supply and demand in the heart. The second, a systolic time interval, monitors left ventricular performance. Both indices are applicable to most dynamic and static circulatory conditions and are suitable for beat-to-beat evaluation in patient care.
ENDOCARDIAL VIABILITY RATIO
CASE HISTORYA 26-year-old woman gave vaginal birth to her first child in a small Australian provincial hospital and developed complications during the delivery, including a pulmonary amniotic embolus. She was transferred by air to the Royal Newcastle Hospital and admitted to the intensive care unit. The patient was hypotensive and in respiratory distress. Laboratory studies showed hypoxemia, anemia, coagulopathy, and bilateral infiltrates on chest x-ray. She was treated by mechanical ventilation with PEEP, fluid administration, intravenous coagulation factors, and blood. Because of the delay in therapy she developed significant arterial hypotension, presumably from endogenous vasoactive substances released after the amniotic fluid embolus. Her diastolic pressure was most affected, while systolic pressure seldom fell below 80 torr (a sign of a basically strong heart). In order to monitor her cardiac function a modified V5 ECG lead was placed, and a small special purpose computer was attached to the output from the radial artery pressure transducer to measure the endocardial viability ratio (EVR). Whenever her heart rate accelerated above 100 beats/min and the diastolic pressure fell below 40 torr, cardiac ischemia recurred as manifested by ST segment changes in V5. Yet prior to the ECG evidence of myocardial hypoxia, the EVR fell below 0.4, a level well under the suspected "break point" for subendocardial ischemia. 1 By judicious use of dobutamine and phenylephrine her blood pressure and left-sided heart work were regulated to avoid cardiac ischemia so that the EVR remained above 0.4. There was no further ECG evidence of cardiac ischemia. Unfortunately, she suffered from an unremitting coagulopathy and died after a major cerebral hemorrhage associated with severe hypoxemia.The endocardial viability ratio (EVR) was described by Buckberg and colleagues in 1972 and is based on two precepts. 2 First, the work of Sarnoff and associates was used to show that the left ventricular (LV) stroke oxygen consumption is proportional to the area under the LV pressure curve. 3 This area, called the time tension index (TTI), may be calculated from a peripheral pulse instead of the LV curve by ignoring the isovolemic contraction and relaxation areas (Fig. 1). Correlations between left-sided heart oxygen consumption and the area under the systolic portion of the pulse wave are close and reproducible over wide ranges of left-sided heart work. 4 Second, the gradient between aortic diastolic and left ventricular diastolic pressures is thought to describe the perfusion head for subendocardial coronary blood flow. 1 Because perivascu...