Complications of radical hysterectomy with pelvic lymph node dissection for cervical cancer: a 10-year single-centre clinical observational study

Abstract

Background and purpose The complications of radical surgery for cervical cancer can increase patient suffering and affect their quality of life. This retrospective study assessed the safety of radical hysterectomy (RH) with pelvic lymph node dissection (PLND) by observing the complications of patients with cervical cancer who underwent this procedure in a single centre over 10 years. Our findings may provide experience and evidence for preventing and reducing complications. Methods A total of 2226 cervical cancer patients who met the inclusion criteria were enrolled. All patients underwent RH + PLND. Intraoperative injury to adjacent tissues and short-term and long-term complications were recorded to analyze factors associated with the occurrence of complications. Results Postoperative complications occurred in 34.41% (766/2226) of patients, including 7.68% of patients with injury to adjacent tissues, 31.45% with short-term complications, and 2.96% with long-term complications. Age, tumor size, invasion depth, parametrial invasion, lymph vascular space invasion (LVSI), lymph node metastasis, International Federation of Gynaecology and Obstetrics (FIGO) stage, and surgical procedure were closely associated with the postoperative complications of RH + PLND (P < 0.05). Conclusions The results of this study showed that RH + PLND for cervical cancer is safe and practical. Patients aged 40–60 years, with tumors ≥ 4 cm, invasion depth ≥ 2/3, parametrial invasion, LVSI, lymph node metastasis, FIGO stage > IB2, and who underwent open surgery were more prone to complications.

Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in Two Referral Hospitals in Cameroon

“…However, there were no significant associations between any disease, procedure or patients' characteristics and the occurrence of adverse surgical outcomes. These findings contrast with what is reported in literature by many authors who describe factors like FIGO stage IB, parametrial invasion, advance age of the patient, tumor size like predictors of complications [27]. Some studies suggest that when minimal invasive surgery is used, there is reduced hospital stay, hemorrhagic complications and pelvic pains but both the short term and long term complications are comparable for the 2 approaches [28].…”

Beyond bladder dysfunction: assessing the full impact of radical hysterectomy on cervical cancer patients

“…Functional disorders are the most commonly reported complications and are thought to be caused by the disruption of sympathetic and parasympathetic nerves during the resection of posterior, anterior and lateral parametria, which run towards the bladder and rectum in the inferior portion of uterosacral ligaments, cardinal ligaments and bladder pillars [8][9][10]. Therefore, the most common symptoms in the first year after surgery are bladder atony and urinary retention [11]. Bladder dysfunction has been reported to occur in up to 47% of cases [12][13][14].…”

Clinicopathological and etiological characteristics for urinary tract infection in cervical cancer patients with radical surgery with double J stents

“…The pathogens of urinary tract infection varied during JJ stent indwelling. About 20.83% (5/24) patients experienced two different kinds of pathogens and 12.50% (3/24) patients experienced ≥ three kinds of pathogens (Table 3 & 4). Results from the antibiotic sensitivity analysis of Escherichia coli (Ecoli), the most common pathogen of urinary tract infections, demonstrated that Ecoli was resistant to Ampicillin, Ceftriaxone, Cefotaxime, Cefazolin and Cefuroxime.…”