Complications of Postoperative and Preoperative Radiation Therapy in Head and Neck Cancers: A Comparative Study

Mantravadi, Rao V.P.; Skolnik, Emanuel M.; Applebaum, Edward L.

doi:10.1001/archotol.1981.00790470038009

Cited by 56 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The influence of irradiation is still controversial. 15,20,[24][25][26][27][28] In the present study, a significant result was observed only in the univariate analysis of cervical skin flap necrosis. Because information about the irradiation dose, irradiation area, and interval between irradiation and reconstructive surgery were not available in this study, further examination is warranted.…”

Section: Discussioncontrasting

confidence: 65%

See 1 more Smart Citation

Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 65%

“…Few studies have reported that age is a significant risk factor for wound complications, and our results are consistent with these. The influence of irradiation is still controversial . In the present study, a significant result was observed only in the univariate analysis of cervical skin flap necrosis.…”

Section: Discussioncontrasting

confidence: 57%

Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Wound complications (ie, infection, flap necrosis, and fistula) after head and neck surgery are associated with increased hospitalization, resource utilization, and patient anxiety and morbidity. [29][30][31] These complications may impede rehabilitation and delay additional postoperative therapy. Multiple factors contributing to increased risk of wound complications have been implicated, including prior radiotherapy, chemoradiotherapy, malnutrition, duration of surgery, anemia, tobacco use, medical comorbidity, and others.…”

Section: Commentmentioning

confidence: 99%

Complications in Head and Neck Surgery

Paydarfar

Birkmeyer²

2006

Arch Otolaryngol Head Neck Surg

289

103

View full text Add to dashboard Cite

Objective: To summarize the potential risk factors for postlaryngectomy pharyngocutaneous fistula.Data Sources: Observational studies in the Englishlanguage literature about postlaryngectomy pharyngocutaneous fistula from January 1, 1970, to March 31, 2003 Studies were identified through a MEDLINE search with relevant key words; additional studies were identified through references. Study Selection:We included studies about the site of primary malignancy, type of procedure, and type of closure; studies had to have been based on individuallevel data, with a comparison group for each risk factor evaluated.Data Extraction: Data required to calculate the relative risk of fistula associated with commonly reported risk factors were abstracted from the studies, and a meta-analysis using a random-effects approach was performed to estimate a summary relative risk of fistula for each risk factor. The statistical signifi-cance of heterogeneity of effects among studies was assessed. Data Synthesis:Of 65 studies identified, 26 met the inclusion criteria. Significant risk factors identified in the pooled analysis included postoperative hemoglobin level less than 12.5 g/dL, prior tracheotomy, preoperative radiotherapy, and preoperative radiotherapy and concurrent neck dissection. The degree of heterogeneity of effects among studies was significant for postoperative hemoglobin level, preoperative radiotherapy, concurrent neck dissection, and comorbid illness. The severity of fistula was greater in patients with a history of radiotherapy.Conclusions: This meta-analysis identified several significant risk factors for postlaryngectomy pharyngocutaneous fistula. The clinical implications of these findings and the potential sources of heterogeneity of effects among studies are discussed.

show abstract

“…Adjuvant irradiation to the spine is now common practice for malignant spinal neoplasm, although irradiation and surgery have never been compared with surgery alone in a large-scale trial. The rationale for RT is to achieve local control of the residual mass in the resection site, which is a common practice in other oncologic fields15). In patients with metastatic tumor, Townsend et al25) reported that the group received metastatic tumor surgery plus postoperative RT had a striking survival advantage over the surgery-only group, with actuarial median survival duration of 12.4 months versus 3.3 months.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Perioperative Radiation Therapy on Spinal Bone Fusion Following Spine Tumor Surgery

Kim

Cho

Youn

et al. 2016

J Korean Neurosurg Soc

View full text Add to dashboard Cite

IntroductionPerioperative irradiation is often combined with spine tumor surgery. Radiation is known to be detrimental to healing process of bone fusion. We tried to investigate bone fusion rate in spine tumor surgery cases with perioperative radiation therapy (RT) and to analyze significant factors affecting successful bone fusion.MethodsStudy cohort was 33 patients who underwent spinal tumor resection and bone graft surgery combined with perioperative RT. Their medical records and radiological data were analyzed retrospectively. The analyzed factors were surgical approach, location of bone graft (anterior vs. posterior), kind of graft (autologous graft vs. allograft), timing of RT (preoperative vs. postoperative), interval of RT from operation in cases of postoperative RT (within 1 month vs. after 1 month) radiation dose (above 38 Gy vs. below 38 Gy) and type of radiation therapy (conventional RT vs. stereotactic radiosurgery). The bone fusion was determined on computed tomography images.ResultBone fusion was identified in 19 cases (57%). The only significant factors to affect bony fusion was the kind of graft (75% in autograft vs. 41 in allograft, p=0.049). Other factors proved to be insignificant relating to postoperative bone fusion. Regarding time interval of RT and operation in cases of postoperative RT, the time interval was not significant (p=0.101).ConclusionSpinal fusion surgery which was combined with perioperative RT showed relatively low bone fusion rate (57%). For successful bone fusion, the selection of bone graft was the most important.

show abstract

Complications of Postoperative and Preoperative Radiation Therapy in Head and Neck Cancers: A Comparative Study

Cited by 56 publications

References 9 publications

Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

Complications in Head and Neck Surgery

The Effect of Perioperative Radiation Therapy on Spinal Bone Fusion Following Spine Tumor Surgery

Contact Info

Product

Resources

About