Background: An enterocutaneous fistula is the abnormal communication between two epithelialized surfaces, one of which is a hallow organ. The discharge of intestinal content into the skin constitutes major nursing challenge. The most important complications include infection and sepsis, electrolyte imbalances and malnutrition, which when not managed properly will lead to grave outcome. Aims: To evaluate the causative factors, the various modes of management and the outcome of such intervention. Methods: Retrospective study of the patients admitted and treated for enterocutaneous fistula due to operative causes were evaluated in Dept of General Surgery S.C.B. Medical College and Hospital, Cuttack from 2014 to 2016. Results: Enterocutaneous fistula frequently follow emergency surgery on gastrointestinal tract, particularly the ileum, duodenum and colon, usually occurring around the 7th postoperative day and most end in spontaneous closure with conservative therapy. Surgery should be restricted to treatment of specially indicated patients like prolonged continuous fistulous discharge, abdominal wound dehiscence and deep seated intra peritoneal abscess. Conclusions: The total management of enterocutaneous fistula involves skilled nutritional support, stoma therapy, elimination of sepsis and finally a carefully timed, well-judged and well carried out surgery which will result in favourable outcome in patients with this dreaded complication.