Complications of New Medications

Abstract

Numerous mandibular pathologies are diagnosed in the emergency department (ED). We present the case of a woman with severe right-sided mandibular pain who was found to have a pathological fracture and osteonecrosis of the jaw (ONJ). The etiology of ONJ was found to be associated to previous use of zoledronic acid to treat osteoporosis. The aim of this case report is to discuss the etiology, diagnosis and treatment of ONJ secondary to the use of zoledronic acid and to outline a clinical condition rarely seen in the ED whose incidence might rise with the increasing use of bisphosphonates.

Case report of maxillofacial fracture in a patient under bisphosphonates in the absence of ONJ disease: Guidelines?

“…The initial search rendered 4 articles selected for full text reading [ 1 , [13] , [14] , [15] ]. Because of the limited articles that were found, the exclusion criteria were removed from the search, adding another 2 studies [ 2 , 16 ]. None of these suggest any guidelines concerning the topic.…”