Complications of Nasopharyngeal Swabs and Safe Procedures for COVID-19 Testing Based on Anatomical Knowledge

Kim, Dai Hyun; Kim, Dasom; Moon, Jee Won; Chae, Sung Won; Rhyu, Im Joo

doi:10.3346/jkms.2022.37.e88

Cited by 18 publications

(21 citation statements)

References 46 publications

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“…Complication from Nasopharyngeal swabs are uncommon with an estimated rate of 1.24 per 100,000 SARS-CoV-2 tests performed ( Koskinen et al, 2021 ). However epistaxis, retained swabs and even CSF leakage have been reported ( Kim et al, 2022 ). In a currently unpublished study of the Rhinoswab™ conducted on 15,519 asymptomatic students (personal communication Peter Jordan, Rhinomed Ltd) and a study involving 250 symptomatic children ( Tosif et al, 2022 ) no such complications were reported.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a novel anterior nasal swab for the detection of SARS-CoV-2

Crowe¹,

Lorenzo²,

Jardine³

et al. 2023

Journal of Virological Methods

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Section: Discussionmentioning

confidence: 99%

Evaluation of a novel anterior nasal swab for the detection of SARS-CoV-2

Crowe¹,

Lorenzo²,

Jardine³

et al. 2023

Journal of Virological Methods

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“…Safety procedures were performed according to procedural references for safe nasopharyngeal swab collection previously described [ 18 , 19 ]. Samples collected on nasopharyngeal swabs were moved to collection tubes containing a viral transport medium by breaking the swab at the groove.…”

Section: Methodsmentioning

confidence: 99%

Comparative Performance of Serological (IgM/IgG) and Molecular Testing (RT-PCR) of COVID-19 in Three Private Universities in Cameroon during the Pandemic

Wouambo

Djuikoue

Esemu

et al. 2023

Viruses

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Background: COVID-19 remains a rapidly evolving and deadly pandemic worldwide. This necessitates the continuous assessment of existing diagnostic tools for a robust, up-to-date, and cost-effective pandemic response strategy. We sought to determine the infection rate (PCR-positivity) and degree of spread (IgM/IgG) of SARS-CoV-2 in three university settings in Cameroon Method: Study volunteers were recruited from November 2020 to July 2021 among COVID-19 non-vaccinated students in three Universities from two regions of Cameroon (West and Centre). Molecular testing was performed by RT-qPCR on nasopharyngeal swabs, and IgM/IgG antibodies in plasma were detected using the Abbott Panbio IgM/IgG rapid diagnostic test (RDT) at the Virology Laboratory of CREMER/IMPM/MINRESI. The molecular and serological profiles were compared, and p < 0.05 was considered statistically significant. Results: Amongst the 291 participants enrolled (mean age 22.59 ± 10.43 years), 19.59% (57/291) were symptomatic and 80.41% (234/291) were asymptomatic. The overall COVID-19 PCR-positivity rate was 21.31% (62/291), distributed as follows: 25.25% from UdM-Bangangte, 27.27% from ISSBA-Yaounde, and 5% from IUEs/INSAM-Yaounde. Women were more affected than men (28.76% [44/153] vs. 13.04% [18/138], p < 0.0007), and had higher seropositivity rates to IgM+/IgG+ (15.69% [24/153] vs. 7.25% [10/138], p < 0.01). Participants from Bangangté, the nomadic, and the “non-contact cases” primarily presented an active infection compared to those from Yaoundé (p= 0.05, p = 0.05, and p = 0.01, respectively). Overall IgG seropositivity (IgM−/IgG+ and IgM+/IgG+) was 24.4% (71/291). A proportion of 26.92% (7/26) presenting COVID-19 IgM+/IgG− had negative PCR vs. 73.08% (19/26) with positive PCR, p < 0.0001. Furthermore, 17.65% (6/34) with COVID-19 IgM+/IgG+ had a negative PCR as compared to 82.35% with a positive PCR (28/34), p < 0.0001. Lastly, 7.22% (14/194) with IgM−/IgG− had a positive PCR. Conclusion: This study calls for a rapid preparedness and response strategy in higher institutes in the case of any future pathogen with pandemic or epidemic potential. The observed disparity between IgG/IgM and the viral profile supports prioritizing assays targeting the virus (nucleic acid or antigen) for diagnosis and antibody screening for sero-surveys.

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“…Safety procedures were performed according to procedural references for safe nasopharyngeal swab collection previously described [18], [19]. Samples collected on nasopharyngeal swabs were moved to collection tubes containing a viral transport medium by breaking the swab at the groove.…”

Section: Nasopharyngeal Samplingmentioning

confidence: 99%

Profile of Serological (IgM/IgG) and Virological Markers of COVID-19 in Some Private Universities in Cameroon During the Pandemic

Wouambo¹,

Djuikoue²,

Esemu³

et al. 2023

Preprint

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Background: COVID-19 remains a rapidly evolving and deadly pandemic worldwide. This necessitates the continuous assessment of existing diagnostic tools for robust, up-to-date and cost-effective pandemic response strategy. We sought to determine the infection rate (PCR-positivity) and degree of spread (IgM/IgG) of SARS-CoV-2 in three university settings in Cameroon Method: Study volunteers were recruited from November 2020 to July 2021 among COVID-19 non-vaccinated students in three Universities from two regions of Cameroon (West and Centre). Molecular testing was performed by RT-qPCR on nasopharyngeal swabs and IgM/IgG antibodies in plasma were detected using the Abbott Panbio IgM/IgG rapid diagnostic test (RDT) at the Virology Laboratory of CREMER/IMPM/MINRESI. The molecular and serological profiles were compared and, p<0.05 considered statistically significant. Results: Amongst the 291 participants enrolled (mean age 22.59±10.43 years), 19.59% (57/291) were symptomatic and 80.41 %(234/2691) asymptomatic. Overall COVID-19 PCR-positivity rate was 21.31% (62/291), distributed as follows: 25.25% from UdM-Bangangte; 27.27% from ISSBA-Yaounde and 5% from IUEs/INSAM-Yaounde. Women were more affected than men (28.76% [44/153] vs. 13.04% [18/138], p<0.0007) and they significantly expressed more IgM+/IgG+ (15.69% [24/153] vs. 7.25% [10/138], p<0.01). Participants from Bangangté, the nomadic, and the “non-contact cases” mainly presented an active infection compared to those from Yaoundé (p= 0.05; p=0.05 and p=0.01 respectively). Overall IgG seropositivity (IgM-/IgG+ and IgM+/IgG+) was 24.4% (71/291). A proportion of 26.92% (7/26) presenting COVID-19 IgM+/IgG- had negative PCR versus 73.08% (19/26) with positive PCR, p<0.0001. Furthermore, 17.65% (6/34) with COVID-19 IgM+/IgG+ had negative PCR as compared to 82.35% positive PCR (28/34), p<0.0001. Lastly, 7.22% (14/194) with IgM-/IgG- had a positive PCR. Conclusion: This study calls for a rapid preparedness and response strategy in higher institutes in case of any future pathogen with pandemic or epidemic potentials. The observed disparity between IgG/IgM and viral profile supports prioritizing assays targeting the virus (nucleic acid or antigen) for diagnosis and antibody screening for sero-surveys

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Complications of Nasopharyngeal Swabs and Safe Procedures for COVID-19 Testing Based on Anatomical Knowledge

Cited by 18 publications

References 46 publications

Evaluation of a novel anterior nasal swab for the detection of SARS-CoV-2

Evaluation of a novel anterior nasal swab for the detection of SARS-CoV-2

Comparative Performance of Serological (IgM/IgG) and Molecular Testing (RT-PCR) of COVID-19 in Three Private Universities in Cameroon during the Pandemic

Profile of Serological (IgM/IgG) and Virological Markers of COVID-19 in Some Private Universities in Cameroon During the Pandemic

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