Complications of Measles during Pregnancy

Atmar, Robert L.; Englund, Janet A.; Hammill, Hunter A.

doi:10.1093/clinids/14.1.217

Cited by 134 publications

(46 citation statements)

References 32 publications

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“…From 1988 to 1991, when there was a resurgence of measles in the US, a number of pregnant women developed measles. Of 13 such women hospitalized in Houston, 54% had respiratory complications requiring admission to an intensive care unit and one died [89]. The cause of severe disease was thought to be primary measles pneumonia.…”

Section: Measlesmentioning

confidence: 99%

Pregnancy and Susceptibility to Infectious Diseases

Sappenfield

Jamieson

Kourtis

2013

Infectious Diseases in Obstetrics and Gynecology

248

142

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To summarize the literature regarding susceptibility of pregnant women to infectious diseases and severity of resulting disease, we conducted a review using a PubMed search and other strategies. Studies were included if they reported information on infection risk or disease outcome in pregnant women. In all, 1454 abstracts were reviewed, and a total of 85 studies were included. Data were extracted regarding number of cases in pregnant women, rates of infection, risk factors for disease severity or complications, and maternal outcomes. The evidence indicates that pregnancy is associated with increased severity of some infectious diseases, such as influenza, malaria, hepatitis E, and herpes simplex virus (HSV) infection (risk for dissemination/hepatitis); there is also some evidence for increased severity of measles and smallpox. Disease severity seems higher with advanced pregnancy. Pregnant women may be more susceptible to acquisition of malaria, HIV infection, and listeriosis, although the evidence is limited. These results reinforce the importance of infection prevention as well as of early identification and treatment of suspected influenza, malaria, hepatitis E, and HSV disease during pregnancy.

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Section: Measlesmentioning

confidence: 99%

Pregnancy and Susceptibility to Infectious Diseases

Sappenfield

Jamieson

Kourtis

2013

Infectious Diseases in Obstetrics and Gynecology

248

142

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“…Pregnant women were also more likely to experience heart failure ( 9 ). A relatively recent outbreak of >1,700 confirmed cases of measles in Houston during 1988–1989 also resulted in a high rate of serious complications among infected pregnant women, which suggests that the outbreak disproportionately affected pregnant women ( 10 ). …”

Section: Pregnancy and Conventional Infectious Disease Threatsmentioning

confidence: 99%

Emerging Infections and Pregnancy

Jamieson¹,

Theiler²,

Rasmussen³

2006

Emerg. Infect. Dis.

503

374

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“…For example, pregnant women have higher mortality associated with varicella virus infection, which is 10 times more likely to be complicated by pneumonia during pregnancy [1, 7, 8]. They are more susceptible to rubeola (measles), and the infection is more likely to cause death [9, 10]. Furthermore, during the 2009 H1N1 influenza pandemic, pregnant women developed more severe flu-related complications, such as hospitalization and death, compared to the general population [11–19].…”

Section: Introductionmentioning

confidence: 99%

Cutting Edge: Fetal/Placental Type I IFN Can Affect Maternal Survival and Fetal Viral Load during Viral Infection

Racicot

Aldo

El-Guindy

et al. 2017

The Journal of Immunology

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Pregnant women have greater mortality and complications associated with viral infections compared to the general population, but the reason for the increased susceptibility is not well defined. Placental type I interferon (IFN) is an important immune modulator and protects the pregnancy. We hypothesized that loss of placental IFN affects the regulation of the maternal immune system, resulting in the differential response to infections observed in pregnancy. Pregnant mice lacking the IFN-α/β receptor (IFNAR) became viremic and had higher mortality compared to non-pregnant animals. Notably, an embryo with functional IFN signaling alone was sufficient to rescue the pregnant IFNAR−/− dam from virus-associated demise. Placental IFN was also an important regulator of viral replication in placental tissue and significantly affected viral transmission to the fetus. These findings highlight the role of fetal/placental IFN in the modulation of viral infection in the mother and fetus.

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Complications of Measles during Pregnancy

Cited by 134 publications

References 32 publications

Pregnancy and Susceptibility to Infectious Diseases

Pregnancy and Susceptibility to Infectious Diseases

Emerging Infections and Pregnancy

Cutting Edge: Fetal/Placental Type I IFN Can Affect Maternal Survival and Fetal Viral Load during Viral Infection

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