Complications of iodide therapy in patients with cystic fibrosis

Nyhan, William L.; Shirkey, Harry C.; Dolan, Thomas F.; Gibson, Lewis E.

doi:10.1016/s0022-3476(71)80324-4

Cited by 22 publications

(4 citation statements)

References 14 publications

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“…These results are not in accordance with the literature which reports frank or subclinical hypothyroidism, either low T 4 and/or T 3 with or without abnormal TSH response to TRH [1,2,3, 17]. A TRH test was not done in our patients, thus subtle alterations in the hypothalamo-pituitary-thyroid axis cannot be excluded; however in the study reporting an exaggerated TSH response to TRH, peripheral abnormalities were also present [3].…”

Section: Discussioncontrasting

confidence: 94%

“…Second, in that period iodine-containing pulmonary expectorants were widely employed. In fact, the first studies reporting abnormal thyroid function in these patients also referred that all subjects were treated with iodine-containing drugs [1, 19]. …”

Section: Discussionmentioning

confidence: 99%

“…In particular an increased incidence of goiter with or without associated hypothyroidism [1], low T 3 [2] and/or low T 4 and rT 3 levels with increased basal and TRH-stimulated TSH levels [3] have been reported. …”

Section: Introductionmentioning

confidence: 99%

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Thyroid Function, Cytokine and IGF-IGFBP Interactions in Cystic Fibrosis Patients

Volta¹,

Street²,

Ziveri³

et al. 2005

Horm Res Paediatr

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Background/Aims: Thyroid function impairment has been sporadically described in cystic fibrosis (CF) and ascribed to iodine overload or selenite deficiency. In this study we evaluated thyroid function in CF in order to verify these data and to evaluate if the modifications were related to serum levels of markers of inflammation and growth factors that we have previously shown to be altered in CF. Methods: Seventeen young adult CF patients and 18 age-matched controls were enrolled in this study. The diagnosis of CF was confirmed by genetic analysis. None was treated with pulmonary expectorants. Serum IL-1β, IL-6, TNF-α, IGF-I, IGF-II, IGFBP-2, IGFBP-3, TSH, fT₃ and fT₄ were measured using standard commercial kits. Results: TSH, fT₃ and fT₄ serum levels were similar in CF patients and controls. Within the patient group, thyroid function did not vary in relation to C-reactive protein serum levels, respiratory function and clinical conditions (Shwachman score). No correlation was found with any growth factor or cytokine analyzed. Conclusions: At variance with the few previously published data, we did not detect any difference in thyroid function in patients with CF compared with normal healthy subjects. This could be due to the fact that no iodine overload or selenite deficiency was present in our patients. Thyroid function seemed independent of markers of inflammation and IGF-IGFBP serum levels.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Thyroid Function, Cytokine and IGF-IGFBP Interactions in Cystic Fibrosis Patients

Volta¹,

Street²,

Ziveri³

et al. 2005

Horm Res Paediatr

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“…Iodide-induced goiter, with or without hypothyroidism, has been reported in the past in patients with CF receiving pulmonary expectorants containing iodides [96]. However, the prevalence of underlying thyroid dysfunction in patients with CF remains controversial with some studies reporting normal thyroid function while others found subclincal hypothyroidism [97–99].…”

Section: Thyroid Diseasementioning

confidence: 99%

Diagnosis and treatment of endocrine comorbidities in patients with cystic fibrosis

Siwamogsatham

Alvarez

Tangpricha

2014

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review The aim of this review is to provide an update on various relevant endocrine aspects of care in adolescents and adults with cystic fibrosis (CF). Recent findings As life expectancy in CF has continuously improved, endocrine complications have become more apparent. The common endocrine complications include cystic fibrosis related diabetes (CFRD), cystic fibrosis related bone disease, vitamin D deficiency and poor growth and pubertal development. Thyroid and adrenal disorders have also been reported, although the prevalence appears to be less common. Summary Endocrine diseases are an increasingly recognized complication that has a significant impact on the overall health of individuals with CF. This review summarizes the updated screening and management of endocrine diseases in the CF population.

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