Complications of Injection Laryngoplasty Using Calcium Hydroxylapatite

DeFatta, Rima A.; Chowdhury, Farhad R.; Sataloff, Robert T.

doi:10.1016/j.jvoice.2011.08.005

Cited by 74 publications

(60 citation statements)

References 16 publications

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“…Although the materials are approved for in vivo use in facial tissue, any tissue reaction in the vocal fold might differ from that of facial tissue, inducing an unexpected serious foreign body granuloma. [12][13][14] To date, tissue reactions in the vocal fold, and the long-term effects of such reactions in vivo, are unknown.…”

Section: Discussionmentioning

confidence: 99%

Utility and Safety of Commercially Available Injection Laryngoplasty Materials in a Rabbit Model

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Utility and Safety of Commercially Available Injection Laryngoplasty Materials in a Rabbit Model

et al. 2015

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“…It should be used with full understanding of the potential serious adverse reactions and risk of at least minor impairment of vibratory function. 17 In animal studies, we demonstrated that injected cartilage had little or no resorption in the vocal fold at 3 years after injection. 14,15 There was no disturbance of mucosal vibration because the autologous cartilage was injected into the vocalis muscle.…”

Section: Discussionmentioning

confidence: 82%

Intracordal auricular cartilage injection for unilateral vocal fold paralysis

Lim

Lee

et al. 2014

J. Biomed. Mater. Res.

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We evaluated the efficacy and outcome of intracordal auricular cartilage injection in patients with unilateral vocal fold paralysis. Our interest developed from findings of a canine model study that reported that histologic characteristics of cartilage were preserved 2 and 3 years after intracordal autologous cartilage injection. Between May 2002 and July 2010, 29 patients with breathy dysphonia caused by unilateral vocal fold paralysis underwent intracordal auricular cartilage injection. Each subject underwent preoperative and postoperative perceptual assessments, acoustical voice analysis, and videostroboscopy. Fourteen patients were male, and the mean age was 52-years old. Patients were tracked for a mean duration of 257 days. Injections were performed through a transoral approach under general anesthesia. Perceptual assessments by GRBAS scale, acoustic parameters of jitter, shimmer, noise-to-harmonic ratio, and maximum phonation time significantly improved at 3, 6, and 12 months after cartilage injection (p < 0.005). No major complications were observed after injection. Initial clinical results with intracordal auricular cartilage injection are promising for patients with unilateral vocal fold paralysis. Autologous auricular cartilage can be a safe, effective, and alternative material for vocal fold medialization, and can be a long lasting one.

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“…In case of inadvertent superficial injection, the surgeon must weigh the potential for damage from surgery to remove superficial material against the potential for permanent dysphonia if left untreated. Despite the generally very well-tolerated nature of most currently available vocal fold injectables, isolated reports of foreign body or even systemic allergic reactions exist, notably to calcium hydroxylapatite [37][38][39] and polydimethylsiloxane [40,41]. As a general observation, all vocal fold augmentation materials, although apparently much friendlier to tissue than their historical antecedents, paraffin and polytetrafluoroethylene paste (Teflon), fare best when placed as deep as possible in the muscle of the vocal fold, to insulate the delicate vibratory tissue at the vocal fold margin from mass effect and inflammation.…”

Section: Methodsmentioning

confidence: 99%

In-Office Laryngeal Injection

Sulica

Mor

2015

Curr Otorhinolaryngol Rep

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Originally described more than a century ago, vocal fold injection in the awake, unsedated patient has returned to routine clinical use because of improved injectable materials and flexible laryngoscopy optics. The vocal fold may be injected via a number of approaches to remedy conditions of glottic insufficiency including vocal fold paralysis and paresis, atrophy, and scar. Its use in the treatment of treating benign mass lesions is an evolving topic. Trial injections may be performed in cases of uncertain benefit, a use which has revealed the importance of glottic insufficiency in an unexpected variety of complaints. Injection materials are generally well tolerated, although injection into the superficial tissues of the vocal folds is to be avoided. Although laryngeal injection in the awake patient demands some technical expertise and finesse, procedure completion rates are high with low rates of complications, comparable to injection under anesthesia.

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Complications of Injection Laryngoplasty Using Calcium Hydroxylapatite

Cited by 74 publications

References 16 publications

Utility and Safety of Commercially Available Injection Laryngoplasty Materials in a Rabbit Model

Utility and Safety of Commercially Available Injection Laryngoplasty Materials in a Rabbit Model

Intracordal auricular cartilage injection for unilateral vocal fold paralysis

In-Office Laryngeal Injection

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