Complications of donor apheresis

Winters, Jeffrey L.

doi:10.1002/jca.20039

Cited by 88 publications

(86 citation statements)

References 63 publications

(102 reference statements)

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“…Overall, evidence in the literature suggests that the frequency of reactions to apheresis donation is less than that seen in whole blood donation. 7,8 The adverse events during the process of plateletpheresis have been broadly divided into: 5,6,8 • Venipuncture related • Syncope/sweating/faintness • Citrate reactions Pain at the site of venipuncture was noted to be more common because the same vein in one arm is used for inflow and return, resulting in trauma and hematoma to the vein. Citrate is used as primary anticoagulant in donor apheresis procedures.…”

Section: Resultsmentioning

confidence: 99%

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

et al. 2017

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Background: Plateletpheresis is the process of collecting platelets, a component of blood involved in blood clotting. The term specifically refers to the method of collecting the platelets, which is performed by a device used in blood donation that separate the platelets and return other portion of blood to the donor. Platelet transfusion can be a life-saving procedure in preventing and treating serious complications from bleeding and haemorrhage in patients having disorders manifesting as thrombocytopenia like in dengue patients, ITP, aplastic anemia, and patients undergoing chemotherapy for leukaemia. In this study, our goal was to retrospectively analyse the adverse reactions occurred during and immediately after plateletpheresis donations.Methods: From January 2015 to October 2016, a total of 66 plateletpheresis procedures were performed in department of transfusion medicine, GMC Jammu, Jammu and Kashmir, India which is a tertiary care hospital.Results: Total 66 procedures were performed during our study period from which, four (6.06%) adverse events were recorded. Out of these four, two (50%) donors suffered from tingling sensation, one (25%) suffered from nausea and vomiting and One (25%) from haematoma formation.Conclusions: In Conclusion, the result of our 22-month study survey document that apheresis procedures performed on cell separators are safe procedures with the low incidence of adverse reactions.

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Section: Resultsmentioning

confidence: 99%

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

et al. 2017

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“…Severe outcomes [30,43], arterial puncture [44], citrate toxicity, severe injuries to subcutaneous nerves [45,46,47,48,49,50], thrombosis of upper extremity veins [51,52], formation of an arteriovenous fistula [53,54], pseudoaneurysm [55,56,57], or compartment syndrome [58] are all extremely rare, as are some other rare events [59]. We did not see any of these rare UEs [60,61,62]. …”

Section: Discussionmentioning

confidence: 99%

Donor Hemovigilance during Preparatory Plasmapheresis

Diekamp¹,

Gneißl²,

Rabe³

et al. 2014

Transfus Med Hemother

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Background: Reports on unexpected donor events (UEs) during preparatory plasmapheresis (PPP) are scarce, and rarely consider technical UEs. Methods: Defined local and systemic UEs were graded by severity; technical UEs were not graded. On January 1, 2008, E.B.P.S.-Logistics (EBPS) installed the UE module for plasma management software (PMS). Donor room physicians entered UEs daily into the PMS. Medical directors reviewed entries quarterly. EBPS compiled data on donors, donations and UEs from January 1, 2008 to June 30, 2011. Results: 66,822 UEs were observed during 1,107,846 PPPs for a corrected incidence of 6.55% (1.4% local, 0.55% systemic, 4.6% technical UEs). 3.36% of PPPs were accompanied by 1 UE and 1.18% by >1 UE (2-5). 13.7% of donors undergoing PPP for the first time, 9.7% of those having a second PPP and 4.0% of those having a third or more PPPs were associated with UEs. Most common UEs were repeated venipuncture, and broken-off collection due to venous access problems and small hematomas. Severe systemic UEs occurred at a rate of 36 per 100,000 PPPs. Conclusions: Technical UEs were common with PPP. UEs accompanied first and second donations significantly more frequently than for subsequent donations.

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“…the automated cell separators which facilitate in-line separation of cellular from plasma component and then, selective extraction of required component with the 'depleted blood' being returned back to the donors. Many authors have reported the apheresis as a safer procedure which is associated with less frequent adverse donor reactions as compared to whole blood donations [2,3]. A multi-centric study reported the frequency of adverse reactions observed in apheresis donations ranges from 0.32 to 6.81 % [4].…”

Section: Introductionmentioning

confidence: 99%

“…vasovagal reactions, hypovolemia, haematoma formation, etc. ), these are associated with few unique adverse events which are not associated with standard phlebotomies and/or whole blood donations [2,3]. These may be attributed to the usage of anticoagulant 'Acid-Citrate-Dextrose' (ACD) causing hypocalcemia and longer donation periods [4].…”

Section: Introductionmentioning

confidence: 99%

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

Dogra

Fulzele

Rout

et al. 2016

Indian J Hematol Blood Transfus

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Apheretic platelets are better quality blood components which reduce donor exposure and chances of TTIs to transfusion recipients when compared to the whole blood derived components. Though safe, these apheretic donations are associated with donor adverse events. We evaluated the incidence of such adverse events associated with the modern apheresis procedures that would provide an insight as well as help formulating preventive steps to avoid frequent occurrences of such events. This prospective audit-based observational study was conducted over 1 year. Donors for plateletpheresis were selected as per the standard operating procedure of the Apheresis Lab. The apheresis procedures were done on the MCS? (Haemonetics Corp.), Trima Accel (Terumo BCT) and COM.TEC (Fresenius Kabi AG). 1740 apheresis procedures were performed, out of which 1708 were plateletpheresis and 32 therapeutic plasma exchange (TPE) procedures for 7 patients. A total of 102 adverse events were noted; of which, 80 (78.43 %) events were associated with donors, 15 (14.71 %) were owed to equipment related problems and 7 (6.86 %) were technical aberrations. All the events associated with donors were mild. No adverse events were reported with any of the 32 TPEs. Apheresis procedures are associated with adverse events which can be reduced by meticulous donor-vigilance, superior training modules for the technical personnel and continued supervision of experienced transfusion medicine specialists. Continued efforts towards making the donor's experience with apheresis more pleasant give a forward thrust to the noble vision of preparing a voluntary apheresis donor pool in India.

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Complications of donor apheresis

Cited by 88 publications

References 63 publications

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

Donor Hemovigilance during Preparatory Plasmapheresis

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

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