Complications of diabetes: renal disease and promotion of self-management

Melville, A; Richardson, Rachel; Lister-Sharp, D; McIntosh, Aileen

doi:10.1136/qhc.9.4.257

Cited by 10 publications

(8 citation statements)

References 93 publications

(51 reference statements)

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“…Therefore, we sequenced the entire coding sequence and exon/intron boundaries of the Hnf-1 β gene, which is responsible for MODY5 exhibiting diabetes and renal malformation in humans, and found no mutation in the Hnf-1 β gene of affected rats in the DEK strain (data not shown). DN is one of the complications in diabetes and a leading cause of chronic kidney diseases in humans [34]. To date, various DN animal models have been studied to elucidate the mechanisms and genetic factors involved in the development and progression of DN [13, 35].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys

Domon

Katayama

Tochigi

et al. 2019

Journal of Diabetes Research

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A variety of animal models of diabetes mellitus (DM) are required to study the genetics and pathophysiology of DM. We established a novel rat strain showing nonobese type 2 diabetes with enlarged kidneys from the LEA.PET-pet congenic strain and named it Diabetes with Enlarged Kidney (DEK). The body growth of DEK affected rats was similar to that of normal rats before the development of DM but was attenuated with the deterioration of DM. There was a marked difference in the etiology of DEK by gender: DM phenotypes including polyuria, polydipsia, and hyperglycemia (nonfasting blood glucose over 300 mg/dl) were found in male rats aged over 10 weeks but not in female rats. The cumulative incidence of DM in DEK males at the age of 30 weeks was 44.8%. Oral glucose tolerance tests showed glucose intolerance and decreased insulin secretion in response to glucose loading in affected males, features which were exacerbated with age. Affected males exhibited disorganized architecture of pancreatic islets, decreased numbers of β cells, and markedly decreased expression of insulin, despite no pathological findings of hemorrhage or infiltration of inflammatory cells in the pancreatic islet. Age-related islet fibrosis appeared similar in normal and affected males. Affected males also showed enlarged kidneys with dilation of renal tubules in both the cortex and medulla, but no obvious glomerular lesions typical of diabetic nephropathy (DN) at the age of 30 weeks. Plasma levels of urea nitrogen and creatinine were normal, but hypoalbuminemia was detected. These pathophysiological features in affected males indicated that their renal function was almost maintained despite severe DM. Taken together, these findings indicate that the affected males of the DEK strain are a novel nonobese type 2 diabetes rat model useful for studying the mechanisms underlying β cell loss and identifying genetic factors protective against DN.

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Section: Discussionmentioning

confidence: 99%

Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys

Domon

Katayama

Tochigi

et al. 2019

Journal of Diabetes Research

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“…Self-care education has been shown to improve laboratory data in several chronic diseases [10, 11]. However, one study in Japanese patients with renal diseases showed that scores for dietary self-assessment did not match with actual data for the serum urea nitrogen/urea creatinine ratio.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Patients with Minimal Change Nephrotic Syndrome

Shutto

Yamabe

Shimada

et al. 2013

The Scientific World Journal

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Aim. The goal of the study was to investigate quality of life (QOL) in adult patients with minimal change nephrotic syndrome (MCNS) and to test the relationship of QOL with the level of self-care. Materials and Methods. We distributed two questionnaires to 30 outpatients with MCNS. The MOS 36-item Short Form Health Survey (SF-36v2) was used to examine health-related QOL in comparison with normative data from the general Japanese population and a population with two chronic diseases. SF-36v2 consists of 36 questions classified into 8 subscales. We also used the Self-Care Behavior Scale for patients with chronic kidney disease (CKD), which consists of 31 questions with 4 subscales. Results. The SF-36v2 social functioning subscale was most impaired and bodily pain was least affected in patients with MCNS. The self-care subscales of information/communication and positive behavior had positive correlations with the QOL subscales of mental health (P<0.05) and vitality (P<0.05). The correlation between social functioning and information/communication was close to significant (P=0.051). Conclusion. In MCNS, social functioning was particularly impaired. Our results suggest that better self-care can have a positive impact on QOL in patients with MCNS.

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“…A variety of interventions aimed at promoting self-management have been shown to lead to improved glycaemic control, weight loss and lower BP, but generally the effects are small 15 and there is no evidence of longterm benefits. Another review of RCTs of selfmonitoring in diabetes 16 showed no improvements in blood glucose levels in those who self monitor.…”

Section: Discussionmentioning

confidence: 99%