Complications in the First 5 Years Following Cataract Surgery in Infants With and Without Intraocular Lens Implantation in the Infant Aphakia Treatment Study

Drews‐Botsch, Carolyn; Russell, Buddy; Ward, Michael; Hardy, Robert J.; Birch, Eileen E.; Cheng, Ken; Hertle, Richard W.; Kollman, Craig; Yeargin‐Allsopp, Marshalyn; McDowell, Cyd; Lynn, Michael; Bridgman, Betsy; Celano, Marianne; Cleveland, Julia; Cotsonis, George; Drews-Botsch, Carey; Freret, Nana; Lu, Lu; Swanson, Seegar; Tutu-Gxashe, Thandeka; Busettini, C.; Hayley, Samuel; Beck, Allen D.; Everett, Donald F.; Hartmann, E. Eugenie; Carrigan, Anna K.; Edwards, Colin G.; Wilson, M. Edward; Bozic, Margaret; VanderVeen, Deborah K.; Mansfield, Theresa A.; Miller, Kevin F.; Christiansen, Stephen P.; Bothun, Erick D.; Holleschau, Ann M.; Jedlicka, Jason; Winters, Patricia; Lang, J; Traboulsi, Elias I.; Crowe, Susan; Cimino, Heather Hasley; Yen, Kimberly G.; Castanes, Maria; Sanchez, Alma; York, Shirley; Lambert, Scott R.; Hutchinson, Amy K.; DuBois, Lindreth; Robb, Rachel; Shainberg, Marla J.; Wheeler, David T.; Stout, Ann U.; Rauch, Paula K.; Beaudet, Kimberly; Berg, Pam; Buckley, Edward G.; Freedman, Sharon F.; Duncan, Lois; Phillips, Barratt; Petrowski, John T.; Morrison, David G.; Owings, Sandy; Biernacki, Ron; Franklin, Christine; Plager, David A.; Neely, Daniel E.; Whitaker, Michele; Bates, Donna; Donaldson, Dana; Kruger, Stacey J.; Tibi, Charlotte; Vega, Susan; Weakley, David R.; Stager, David R.; Felius, Joost; Dias, Clare; Sager, Debra L.; Brantley, Todd; Örge, Faruk

doi:10.1016/j.ajo.2014.07.031

Cited by 129 publications

(81 citation statements)

References 21 publications

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“…As reported in previous studies, 5,8,10,11,15,16 VAO requiring surgical intervention is the most frequent complication in our study as well (Table 3). Membranectomy constituted 53.3% (24/45) of all the secondary interventions.…”

Section: Discussionsupporting

confidence: 88%

“…10,16 Although some retrospective studies have reported prevalence of postoperative complications after pediatric cataract surgery, only a few studies have focused on complications that require intervention/ reoperation. [9][10][11] Wilson et al 17 reported a 22% reoperation rate over a 3-year follow-up most commonly for pupillary membranes. Lambert et al 18 reported a 72% reoperation rate for glaucoma, pupillary membranes, VAO, and corectopia.…”

Section: Introductionmentioning

confidence: 99%

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Second intraocular surgery after primary pediatric cataract surgery: indications and outcomes during long-term follow-up at a tertiary eye care center

Sachdeva

Katukuri

Ali

et al. 2016

Eye

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Purpose Although pediatric cataract surgery has become standardized and safe, further surgical interventions are not uncommon. The purpose of this study was to analyze the incidence of complications in children who required an intraocular intervention. Methods A retrospective review of medical records of children (o7 years) with cataract who underwent cataract surgery with or without primary posterior chamber intraocular lens (IOL) placement between January 2006 and December 2014 was carried out. Data were collected regarding visual axis opacification (VAO), glaucoma, IOL decentration, intraocular infections, and other indications that required a second intraocular surgery. Results Out of 814 (570 pseudophakic and 244 aphakic) eyes of 620 operated children, 45 eyes of 40 children (5.5%, 45/814) needed a second surgery. The most common indication being VAO (2.9%, 24/814), followed by glaucoma (0.73%, 6/814). Incidence of complications was higher in children o1 year (VAO 6.1%, 19/308 and glaucoma 6%, 6/308). Among all children, repeat interventions and VAO were slightly less frequent in pseudophakics (4.91%, 28/570) vs aphakics (6.91%, 17/244) (P = 0.31). As VAO was more common in pseudophakic eyes in infants, glaucoma was equally common in both groups. Best-corrected visual acuity improved from 1.6 ± 0.56 LogMAR preoperatively to 0.80 ± 0.50 LogMAR postoperatively. Conclusions Our study suggests that overall incidence of second intraocular surgery is low after primary pediatric cataract surgery. VAO remains the most common indication followed by secondary glaucoma. Incidence of complications is higher in children o1 year of age at initial surgery.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Second intraocular surgery after primary pediatric cataract surgery: indications and outcomes during long-term follow-up at a tertiary eye care center

Sachdeva

Katukuri

Ali

et al. 2016

Eye

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show abstract

“…1 They have addressed issues of concern over a long period in infants <7 months undergoing cataract surgery. The most important difference between the contact lens group and the primary intraocular lens (IOL) group was the need for significantly more surgical procedures to clear the visual axis in the latter.…”

Section: Editor: We Read With Great Interest the Article Published Bymentioning

confidence: 99%

“…Plager and associates have implanted IOL in the bag or sulcus. 1 Koch and Kohnen showed no evidence of posterior capsule opacification (PCO) when an anterior vitrectomy was combined with optic capture of IOL in children 18-24 months of age. 4 This shows that the site of IOL implantation also affects the incidence of visual axis opacification.…”

Section: Editor: We Read With Great Interest the Article Published Bymentioning

confidence: 99%

Complications in the First 5 Years Following Cataract Surgery in Infants With and Without Intraocular Lens Implantation in the Infant Aphakia Treatment Study

Sukhija¹,

Ram²,

Kaur³

2014

American Journal of Ophthalmology

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“…12,14 Children have a greater propensity for postoperative inflammation than adults. 3,8,15 The safety of topical difluprednate after ocular surgery in children has not been previously established. 16 The current study was designed in response to a written request by the US Food and Drug Administration in February 2009 to evaluate the safety of difluprednate 0.05% in children aged 0-3 years for treatment of postoperative inflammation following cataract surgery.…”

Section: Introductionmentioning

confidence: 99%

Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study

Wilson

Lambert

Plager

et al. 2016

Eye

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Purpose To evaluate safety and efficacy of difluprednate 0.05% ophthalmic emulsion for treatment of postoperative inflammation after cataract surgery in pediatric patients. Methods This was a phase 3B, multicentre, randomized, double-masked, active-controlled study of patients aged 0-3 years who underwent uncomplicated cataract surgery in one eye, with/without intraocular lens implantation. Patients were randomized to receive difluprednate 0.05% four times daily or prednisolone acetate 1% for 14 days post surgery, followed by tapering for 14 days. Safety included evaluation of adverse events. Primary efficacy was the proportion of patients with an anterior cell grade of 0 (no cells) at day 14; secondary efficacy was a global inflammation score. Results Forty patients were randomized to each treatment group. Adverse drug reactions included corneal oedema (difluprednate 0.5%, n = 1; prednisolone acetate 1%, n = 0) and increased intraocular pressure or ocular hypertension (n = 2/group). Mean intraocular pressure values during treatment were 2-3 mm Hg higher with difluprednate 0.05% compared with prednisolone acetate 1%; mean values were similar between groups by the first week after treatment cessation. At 2 weeks post surgery, the incidence of complete clearing of anterior chamber cells was similar between groups (difluprednate 0.05%, n = 30 (78.9%); prednisolone acetate 1%, n = 31 (77.5%)). Compared with prednisolone acetate 1%, approximately twice as many difluprednate 0.05%-treated patients had a global inflammation assessment score indicating no inflammation on day 1 (n = 12 (30.8%) vs n = 7 (17.5%)) and day 8 (n = 18 (48.7%) vs n = 10 (25.0%)). Conclusions Difluprednate 0.05% four times daily showed safety and efficacy profiles similar to prednisolone acetate 1% four times daily in children 0-3 years undergoing cataract surgery.

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Complications in the First 5 Years Following Cataract Surgery in Infants With and Without Intraocular Lens Implantation in the Infant Aphakia Treatment Study

Cited by 129 publications

References 21 publications

Second intraocular surgery after primary pediatric cataract surgery: indications and outcomes during long-term follow-up at a tertiary eye care center

Second intraocular surgery after primary pediatric cataract surgery: indications and outcomes during long-term follow-up at a tertiary eye care center

Complications in the First 5 Years Following Cataract Surgery in Infants With and Without Intraocular Lens Implantation in the Infant Aphakia Treatment Study

Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study

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