Complications in cerebral angiography with iohexol (Omnipaque) and meglumine metrizoate (Isopaque cerebral)

Abstract

The complications of cerebral angiography have been recorded in 1509 examinations with metrizoate (Isopaque Cerebral) and in 1000 examinations with iohexol (Omnipaque). The frequency of complications was 2.0 percent for metrizoate and 1.3 percent for iohexol. Permanent sequelae were seen in 4 patients, 3 in the metrizoate and one in the iohexol group. One of these patients died, probably from thromboembolism. Blood coagulation parameters were studied during the angiography in 22 patients and only minor, probably clinically insignificant changes were found, with no difference between the two contrast media.

Cerebral angiographic risk in mild cerebrovascular disease.

“…Unfortunately, this question was not addressed in a subsequent paper. 30 The authors incidentally found no significant difference in side effects between the different contrast media.…”

Neurologic Complications of Cerebral Angiography: Prospective Analysis of 2,899 Procedures and Review of the Literature

“…Despite advances, cerebral angiography continues to be used for the examination of patients with cerebrovascular diseases. In the past decade, safer contrast agents have been used and there have been important technical advances including smaller catheters, hydrophylic guide wires, and digital imaging systems (5)(6)(7). The purpose of this prospective study was to identify the risk factors for neurologic complications that are related to cerebral angiography.…”

CTA IN PATIENTS WITH ACUTE SUBARACHNOID HAEMORRHAGE. A comparative study with selective, digital angiography and blinded, independent review

“…Four‐vessel angiographic examination, performed by an experienced neuroradiologist, is usually a straightforward procedure in these patients, but may occasionally be time consuming. Despite improvements of catheters and contrast media, complications to IA‐DSA occur in approximately 1% of the procedures (5, 9). Minimal‐ or non‐invasive methods replacing IA‐DSA could reduce the time before the aneurysm is treated without exposing these patients to the risk of complications to IA‐DSA.…”