Complications de l’association sulfate de magnésium et nicardipine au cours de la prééclampsie : à propos de 2 cas

Carles, Gabriel; Hélou, Josiane; Alassas, N.; Dallah, F.; Ibrahim, Nour

doi:10.1016/j.gyobfe.2012.07.003

Cited by 6 publications

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References 12 publications

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“…[31–33] Few studies have reported the synergetic effects of the concurrent use of nicardipine and magnesium sulfate for conditions such as hypotension and myocardial depression from disturbance of calcium influx. [4,17,34] In this study, the condition of all patients was severe enough to use postpartum magnesium sulfate for eclampsia prevention; however, none of the patients had the aforementioned adverse effects. However, concomitant use of nicardipine and magnesium sulfate should be monitored carefully when a maternal cardiovascular problem is compromised.…”

Section: Discussionmentioning

confidence: 77%

Use of continuous infusion of nicardipine to control persistent postpartum hypertension: A retrospective study

et al. 2022

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To evaluate the effect of continuous infusion of nicardipine on the management of uncontrolled blood pressure (BP) during postpartum period. This retrospective study included 209 women diagnosed in hospital with hypertensive disorders during pregnancy and had uncontrolled BP after delivery between January 2018 to December 2020 Uncontrolled BP was defined as persistent elevation of systolic BP ≥ 160 mm Hg or diastolic BP ≥ 110 mm Hg. Patients were divided into 2 groups: nicardipine (N = 53; continuous nicardipine infusion and additional bolus of labetalol or hydralazine) and control (N = 156; consecutive bolus of labetalol or hydralazine). BP data were analyzed using the Mann–Whitney U and χ 2 tests by dividing the time interval of 4 hours by the delivery time. The highest BP trends showed that the mean values of both systolic and diastolic BP immediately before delivery were higher in the nicardipine group than in the control. After 8 to 12 hours following delivery, both systolic and diastolic BP were lower in the nicardipine group than in the control. Subsequently, 16 to 20 hours after delivery, both systolic and diastolic BP were significantly lower in the nicardipine group than in the control (137/80 vs 141/84 mm Hg). Initially, the proportions of uncontrolled BP in the nicardipine group were higher than those in the control; however, it then became lower at all time intervals 8 hours after delivery. The proportions of patients who received additional antihypertensive agents and the median cumulative dosages were lower in the nicardipine group than in the control. Continuous infusion of nicardipine can help manage uncontrolled BP during the postpartum period.

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