Complications Associated with Surgical Site Infections

Verwilghen, Denis; Weese, J. Scott

doi:10.1002/9781119190332.ch17

Cited by 1 publication

(2 citation statements)

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“…Surgical site infections are reported in 0-60% of horses (mean of 7.3%), depending upon the surgical classification. 1 Perioperative antimicrobial administration can play a critical role in preventing surgical site infections in horses. Surgical antimicrobial prophylaxis is defined as a brief course of an antimicrobial drug initiated just before an operation begins in the absence of infection.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical site infections are one of the most common and potentially serious complications of equine surgery. Surgical site infections are reported in 0‐60% of horses (mean of 7.3%), depending upon the surgical classification 1 . Perioperative antimicrobial administration can play a critical role in preventing surgical site infections in horses.…”

Section: Introductionmentioning

confidence: 99%

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Potassium penicillin and gentamicin pharmacokinetics in healthy conscious and anesthetized horses

et al. 2022

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To determine the effects of general anesthesia on the safety and efficacy of co-administered potassium penicillin G (PEN) and gentamicin (GENT) in horses. Study design: Nonrandomized crossover.Animals: Six adult, Thoroughbred horses.Methods: Horses were administered PEN (22 000 IU/kg IV) and GENT (6.6 mg/kg IV). Plasma samples were collected over a 6 h period and synovial fluid was collected at 30 min and 6 h respectively. Drug administration and sample collection protocols were repeated after at least a 48 hour washout period and induction of anesthesia using xylazine/ketamine and maintenance with isoflurane gas. Drug concentrations were determined using ultrapressure liquid chromatography with mass spectrometry. A 2-compartment model was used to determine pharmacokinetics and differences were determined between conscious and anesthetized horses using paired t-tests (significance P < .05).Results: Potassium penicillin g and GENT had higher minimum plasma concentrations (PEN 0.44 vs. 0.11 μg/mL, P = .002; GENT 3.0 vs. 1.9 μg/mL, P = .009), longer half lives (PEN 71 vs. 59 min, P = .018; GENT 149 vs. 109 min, P = .038), and slower clearances (PEN 3.41 vs. 5.1 mL/kg/min, P = .005; GENT 1.18 vs. 1.48 mL/kg/min, P = .028) in anesthetized horses vs. conscious horses. The PEN concentrations remained above the breakpoint minimum inhibitory concentration (MIC, 0.5 μg/mL) for 332 min in anesthetized vs. 199 min in conscious horses. The GENT concentrations reached 10 times higher than the breakpoint MIC (2 μg/mL) in all horses and were maintained for 58 vs. 59 min in anesthetized and conscious states, respectively. Synovial fluid concentrations were higher in conscious horses vs. anesthetized horses at 30 min for PEN (7.0 vs. 0.93 μg/mL, P < .001) and 30 (5.3 μg/mL vs. 0.79 μg/mL, P < .001) and 360 min (3.4 vs. 1.82 μg/mL, P < .003) for GENT. Conclusion: General anesthesia resulted in lower intrasynovial concentrations and delayed clearance of PEN/GENT in horses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%