Complications and Sequelae of Otitis Media

Zheng, Min; Wang, Jingshi; Xia, Shuang

doi:10.1007/978-981-16-8841-6_22

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Although the rat middle ear is surrounded by an ectotympanic bone, which is separated from the petrosal bone ( 18 ), it appears important to compare middle ear- and inner ear-associated bone marrow features and distribution, since the middle ear represents the principal site of entry of pathogens and drugs for the inner ear ( 44 , 45 ). Ectotympanic bone marrow ( Figure 11 ) was found in two large islands (total volume 1.54 ± 0.79 mm 3 , n = 4) surrounding the tubal and tympanic opening (see Figure 2C ).…”

Section: Resultsmentioning

confidence: 99%

Temporal bone marrow of the rat and its connections to the inner ear

Perin,

Cossellu,

Vivado

et al. 2024

Front. Neurol.

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Calvarial bone marrow has been found to be central in the brain immune response, being connected to the dura through channels which allow leukocyte trafficking. Temporal bone marrow is thought to play important roles in relation to the inner ear, but is still largely uncharacterized, given this bone complex anatomy. We characterized the geometry and connectivity of rat temporal bone marrow using lightsheet imaging of cleared samples and microCT. Bone marrow was identified in cleared tissue by cellular content (and in particular by the presence of megakaryocytes); since air-filled cavities are absent in rodents, marrow clusters could be recognized in microCT scans by their geometry. In cleared petrosal bone, autofluorescence allowed delineation of the otic capsule layers. Within the endochondral layer, bone marrow was observed in association to the cochlear base and vestibule, and to the cochlear apex. Cochlear apex endochondral marrow (CAEM) was a separated cluster from the remaining endochondral marrow, which was therefore defined as “vestibular endochondral marrow” (VEM). A much larger marrow island (petrosal non-endochondral marrow, PNEM) extended outside the otic capsule surrounding semicircular canal arms. PNEM was mainly connected to the dura, through bone channels similar to those of calvarial bone, and only a few channels were directed toward the canal periosteum. On the contrary, endochondral bone marrow was well connected to the labyrinth through vascular loops (directed to the spiral ligament for CAEM and to the bony labyrinth periosteum for VEM), and to dural sinuses. In addition, CAEM was also connected to the tensor tympani fossa of the middle ear and VEM to the endolymphatic sac. Endochondral marrow was made up of small lobules connected to each other and to other structures by channels lined by elongated macrophages, whereas PNEM displayed larger lobules connected by channels with a sparse macrophage population. Our data suggest that the rat inner ear is surrounded by bone marrow at the junctions with middle ear and brain, most likely with “customs” role, restricting pathogen spread; a second marrow network with different structural features is found within the endochondral bone layer of the otic capsule and may play different functional roles.

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Section: Resultsmentioning

confidence: 99%

Temporal bone marrow of the rat and its connections to the inner ear

Perin,

Cossellu,

Vivado

et al. 2024

Front. Neurol.

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“…1 Main cause of the disease is either hypertrophy of adenoid tissue or nasopharyngeal tumours, which block the Eustachian tube, resulting in absorption of air in the middle ear cleft leading to the development of negative pressure and eventually developing effusion in middle ear cleft. 2 SOM is a commonly seen intractable illness in otolaryngology departments which substantially impacts patient's quality of life. 3 SOM prevalence and persistence are mostly seen in the pediatric age group, which is the major cause of deafness and damage to the tympanic membrane.…”

Section: Introductionmentioning

confidence: 99%

Silent Secretory Otitis Media in Cases with Adenoid Hypertrophy

Fareed

Tahir²,

Bashir³

et al. 2023

PAFMJ

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Objective: to determine the cases brought to the Otolaryngology Department with adenoidal hyperplasia. Study Design: Cross-sectional study. Place and Duration of Study: ENT Department, Combined Military Hospital, Multan Pakistan from Jan to May 2022. Methodology: The study was conducted on children of age more than 2.5 years having adenoid hypertrophy that was confirmed by an X-Ray lateral view of the nasopharynx for adenoids. Their tympanogram was obtained. Results: The study showed that 2(2%) cases had a Type-B curve in a single ear, and 14(14.3%) had a Type-B curve in both ears.PTA was normal in 32(32.7%) cases. Up to 25 decibels (dB) of hearing loss was seen in 6(6.1%) cases. In 8(8.2%) cases, hearing loss, was more than 25Db. Conclusion: The tympanometry test is an objective test which is very easy to carry out and can very easily detect patients having glued ears which can be managed, and possible complications of the disease can be avoided.

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Complications and Sequelae of Otitis Media

Cited by 2 publications

References 8 publications

Temporal bone marrow of the rat and its connections to the inner ear

Temporal bone marrow of the rat and its connections to the inner ear

Silent Secretory Otitis Media in Cases with Adenoid Hypertrophy

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