Complications and post-operative interventions in XEN45 gel stent implantation in the treatment of open angle glaucoma—a systematic review and meta-analysis

Betzler, Bjorn Kaijun; Lim, Siak Piang; Lim, Bee Jik; Yip, Vivien Cherng Hui; Ang, Bryan Chin Hou

doi:10.1038/s41433-022-02022-5

Cited by 4 publications

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The XEN45 gel stent (Allergan, Dublin, Ireland), a subconjunctival MIGS device, has demonstrated good safety and efficacy in the management of open-angle glaucoma [ 71 ], but many investigators have reported the need for postoperative interventions, such as bleb needling, with or without antifibrotic usage, to maintain the long-term patency of the device and sustain its IOP-lowering effect [ 72 , 73 ]. These additional interventions impose additional cost, risk, and inconvenience to both the patient and surgeon.…”

Section: Minimally Invasive Glaucoma Surgery (Migs)mentioning

confidence: 99%

Recent Advancements in Glaucoma Surgery—A Review

Ang,

Lim,

Betzler

et al. 2023

Bioengineering

Self Cite

View full text Add to dashboard Cite

Surgery has long been an important treatment for limiting optic nerve damage and minimising visual loss in patients with glaucoma. Numerous improvements, modifications, and innovations in glaucoma surgery over recent decades have improved surgical safety, and have led to earlier and more frequent surgical intervention in glaucoma patients at risk of vision loss. This review summarises the latest advancements in trabeculectomy surgery, glaucoma drainage device (GDD) implantation, and minimally invasive glaucoma surgery (MIGS). A comprehensive search of MEDLINE, EMBASE, and CENTRAL databases, alongside subsequent hand searches—limited to the past 10 years for trabeculectomy and GDDs, and the past 5 years for MIGS—yielded 2283 results, 58 of which were included in the final review (8 trabeculectomy, 27 GDD, and 23 MIGS). Advancements in trabeculectomy are described in terms of adjunctive incisions, Tenon’s layer management, and novel suturing techniques. Advancements in GDD implantation pertain to modifications of surgical techniques and devices, novel methods to deal with postoperative complications and surgical failure, and the invention of new GDDs. Finally, the popularity of MIGS has recently promoted modifications to current surgical techniques and the development of novel MIGS devices.

show abstract

Section: Minimally Invasive Glaucoma Surgery (Migs)mentioning

confidence: 99%