Complications and Diseases Associated with Atopic Eczema

Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis

“…12 The overall incidence of skin infections in adults and children treated with topical tacrolimus in this study was less than 19% for the entire study period, consistent with or lower than previous reports in patients with AD. [12][13][14]20 In addition, long-term use of 0.1% tacrolimus ointment did not increase the incidence of infections.…”

“…15,16 The overall incidence of cutaneous infections, including HSV, eczema herpeticum, warts, and molluscum contagiosum, among patients treated with tacrolimus ointment in this study (# 4 years) was lower than or consistent with previously published J AM ACAD DERMATOL VOLUME 53, NUMBER 2 reports. 7,[9][10][11][12][13][14][17][18][19][20] Sporadic reports of HSV and eczema herpeticum during topical tacrolimus therapy have emerged; however, these provide no perspective on the frequency or severity. [21][22][23][24] In contrast, a 6% to 10% incidence of HSV was found in 3 separate reports of patients with AD treated conventionally before the availability of topical tacrolimus: a 7.4% incidence in 502 adult patients with ongoing AD 13 ; a 6% incidence in 179 children (age 5 months-8 years) with severe or intractable atopic eczema observed for a period of 2.75 years 18 ; and a 9.7% incidence in 150 pediatric patients with AD.…”

Throwing a Light on Photosensitivity in Atopic Dermatitis

“…An estimated 10% of patients with AD are reported to deteriorate after solar exposure. [1,2] Although sunlight may improve or exacerbate AD, the effect of UV light on AD in clinical practice is often unclear, since the symptoms may also be explained by a host of unrelated circumstantial factors such as humidity, scratching, pollen exposure, psychological factors, skin care, and comorbidities such as polymorphous light eruption (PLE). [3] In the literature, photosensitivity in AD is reported as photoaggravation of AD, [1,[4][5][6][7][8][9][10][11][12][13][14][15][16] photosensitive eczema, [17][18][19] light exacerbated eczema, [20,21] photoexacerbated AD, [22] and even chronic actinic dermatitis (CAD).…”

Safety and Efficacy of 1 Year of Tacrolimus Ointment Monotherapy in Adults With Atopic Dermatitis

“…Eczema herpeticum is a complication of atopic dermatitis arising from herpes simplex infection that resembles varicella. 22 Because cell-mediated immunity is critical for protection against recurrent viral infections, it has been proposed that the compromised cellmediated immunity in patients with atopic dermatitis is responsible for their increased susceptibility to viral superinfections of the skin and the frequent recurrence of lower-grade viral skin infections. 23 Compared with the incidence of eczema herpeticum demonstrated in a survey 24 conducted at a single university clinic, which showed an incidence of approximately 12 patients per year from 1982 to 1986, the incidence observed in the present study (6 patients) is not remarkable.…”