Complications after stereotactic radiosurgery for brain metastases: Incidences, correlating factors, treatments and outcomes

Analysis of the efficacy and prognostic factors of linear accelerator-based hypofractionated stereotactic radiotherapy for brain metastasis of non-small-cell lung cancer

“…In a retrospective trial, analyzed 2,966 patients who received a single SRS treatment for BMs (not limited to primary tumors), and statistical analysis suggested that patients with KPS ≥ 80, primary cancer under control, and no extracranial metastasis may have longer OS and a higher risk of radioactive complications (23). In our study, a multifactor analysis suggested that KPS < 70 is an independent adverse prognosis factor affecting OS (P = 0.024).…”

“…Fifty-one patients (63.8%) received a dose of 30 Gy/3 f PTV. Five patients (6.2%) received a radiotherapy dose less than PTV 30 Gy/3 f and a median dose of 20.6 Gy/3 f in the PTV range of [14][15][16][17][18][19][20][21][22][23][24][25][26][27] Gy/2-3 f. Twenty-four patients (30.0%) received radiotherapy doses greater than PTV 30 Gy/3 f, and PTV median dose of 36.4 Gy/5 f, with a range of PTV 34-45 Gy/3-9 f. For radiotherapy techniques, 37 patients (46.3%) received TOMO, and 43 patients (53.7%) received VMAT.…”

Radiosurgical techniques for the treatment of brain neoplasms: A short review

“…Stereotactic radiosurgery is related to stereotactic neurosurgery and radiotherapy. All three methods are stereotactic methods, as they use the exact positional localization of a target and patient positioning to consistently and accurately direct radiation to the same area[14,15]. They differ by the number of fractions applied to form the total dose received by the patient, as well as the method of application[15].…”

“…All three methods are stereotactic methods, as they use the exact positional localization of a target and patient positioning to consistently and accurately direct radiation to the same area[14,15]. They differ by the number of fractions applied to form the total dose received by the patient, as well as the method of application[15]. In fractional and stereotactic radiotherapy, a number of fractions are given to reach the total dose, with stereotactic radiotherapy differing by stereotactically using a beam aimed at the target.…”

“…The healthy tissue receives a negligible dose of radiation, allowing for decreased morbidity and better quality of life. With the maximum limit of the diameter of the target being around 3 cm, this method is particularly appropriate for the use in small brain metastases and primary intracranial lesions[15,16].…”