Complication Rates After TRUS Guided Transrectal Systematic and MRI-Targeted Prostate Biopsies in a High-Risk Region for Antibiotic Resistances

Wenzel, Mike; Theißen, Lena; Preißer, Felix; Lauer, Benedikt; Wittler, Clarissa; Humke, Clara; Bodelle, Boris; Ilievski, Valentina; Kempf, Volkhard A. J.; Kluth, Luis A.; Chun, Felix K.‐H.; Mandel, Philipp; Becker, Andreas

doi:10.3389/fsurg.2020.00007

Cited by 11 publications

(13 citation statements)

References 33 publications

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“…Thus, complication rates in a transperineal approach with cefpodoxime prophylaxis might be even lower. However, other studies also suggested that a transrectal approach is even safe in regions with increasing proportions and high risk of antibiotic resistance [10].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Complication Rates with Antibiotic Prophylaxis with Cefpodoxime Versus Fluoroquinolones After Transrectal Prostate Biopsy

Wenzel

Welte

Theißen

et al. 2021

European Urology Focus

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Section: Discussionmentioning

confidence: 99%

“…The main noninfectious complications reported after prostate biopsies are hematuria, hematospermia, urinary retention, and rectal bleeding [9]. Antibiotic resistance, especially against fluoroquinolones, has been increasing in recent years [10,11].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Complication Rates with Antibiotic Prophylaxis with Cefpodoxime Versus Fluoroquinolones After Transrectal Prostate Biopsy

Wenzel

Welte

Theißen

et al. 2021

European Urology Focus

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“…However, complications such as hematuria, hemospermia, rectal bleeding, and high fever, most of which are not serious regress spontaneously without treatment. Hematuria and hemospermia are more common than others [2,4,10]. In their review, Borghesi et al [10] indicated that the factors affecting the occurrence of hematuria were releated with method, prostate volume, and comorbidities in prostate biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…The most serious and feared complication is urosepsis. Urosepsis, which is a serious but rare complication, was observed between 0.1% and 2.8% in the literature [3][4][5][6]. Pre-and post-biopsy prophylactic oral quinolone is recommended to prevent these infectious complications [2].…”

Section: Introductionmentioning

confidence: 99%

Prostat biyopsisi yaşlılarda güvenli mi?

Alkış¹,

Başer²,

İvelik³

et al. 2021

Pamukkale Medical Journal

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The study was aimed to investigate the safety of the transrectal ultrasound-guided prostate needle biopsy in the elderly. Material and methods: Five hundered fifteen patients, who underwent prostate biopsy between 2017-2020, were included in the study. All patients' demographic data, comorbidities, laboratory findings, prostate volumes, prostate biopsy pathology results, and post-biopsy complications were retrospectively analyzed. The patients were divided into 2 groups: group-1 consisting of patients under the age of 65 and group-2 with above the age of 65. Results: There were 244 in group-1 and 271 patients in group-2. The mean age of group-1 was 59.50±3.98, group-2 was 71.45±4.57 years. In group-1, post-biopsy fever was observed in 5 (2%), hematuria in 44 (18%), hemospermia in 79 (32.4%), and rectal bleeding in 7 (2.9%) patients. In group-2, post-biopsy fever was observed in 15 (5.5%), hematuria in 69 (25.5%), hemospermia in 21 (7.7%), and rectal bleeding in 11 (4.1%) patients. The severe sepsis findings were observed in 2 patients (0.2%) in group-1 and 6 (2.2%) in group-2. In the logisticregression-analysis, it was determined that the risk of complication increased significantly as the age, PSA, and higher PSA density. Conclusion:In our study, it was revealed that the risk of complications was higher in the elderly and that the complications observed may be more seriously. Therefore, we consider that a more careful approach should be taken in elderly patients to prevent the complications related with prostate biopsy.

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“…Men with elevated serum PSA are sent for transrectal ultrasound (TRUS)guided biopsy for diagnosis and grading of PCa (3). Considered a generally safe and welltolerated outpatient procedure (4), needle biopsy is potentially associated with complications affecting patients' quality of life to various degrees (5,6). Unfortunately, over 50% of biopsies performed on men with elevated PSA were cancer free (7), and 30-50% of the detected cancers were low grade (8).…”

Section: Introductionmentioning

confidence: 99%

Deep neural network analysis employing diffusion basis spectrum imaging metrics as classifiers improves prostate cancer detection and grading

Yang

et al. 2021

Preprint

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Structural and cellular complexity of prostatic histopathology limits the accuracy of noninvasive detection and grading of prostate cancer (PCa). We addressed this limitation by employing a novel diffusion basis spectrum imaging (DBSI) to derive structurally-specific diffusion fingerprints reflecting various underlying prostatic structural and cellular components. We further developed diffusion histology imaging (DHI) by combining DBSI-derived structural fingerprints with a deep neural network (DNN) algorithm to more accurately classify different histopathological features and predict tumor grade in PCa. We examined 243 patients suspected with PCa using in vivo DBSI. The in vivo DBSI-derived diffusion metrics detected coexisting prostatic pathologies distinguishing inflammation, PCa, and benign prostatic hyperplasia. DHI distinguished PCa from benign peripheral and transition zone tissues with over 95% sensitivity and specificity. DHI also demonstrated over 90% sensitivity and specificity for Gleason score noninvasively. We present DHI as a novel diagnostic tool capable of noninvasive detection and grading of PCa.

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Complication Rates After TRUS Guided Transrectal Systematic and MRI-Targeted Prostate Biopsies in a High-Risk Region for Antibiotic Resistances

Cited by 11 publications

References 33 publications

Comparison of Complication Rates with Antibiotic Prophylaxis with Cefpodoxime Versus Fluoroquinolones After Transrectal Prostate Biopsy

Comparison of Complication Rates with Antibiotic Prophylaxis with Cefpodoxime Versus Fluoroquinolones After Transrectal Prostate Biopsy

Prostat biyopsisi yaşlılarda güvenli mi?

Deep neural network analysis employing diffusion basis spectrum imaging metrics as classifiers improves prostate cancer detection and grading

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