Complication of the central nervous system in Kawasaki disease

Ohtsuka, Chikaya; Watanbe, K; Honda, Takeshi; Inoue, Nariaki; Kaneda, Yoshio; Furukawa, Susumu

doi:10.1111/j.1442-200x.1983.tb01684.x

Cited by 4 publications

(5 citation statements)

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“…Patient number in each study was 155 [2], 540 [3], and 177 [5], and there has been only one patient, a 5-year-old boy [2], with FC among them. On meta-analysis of our series and these reports, the incidence was 2/ 1089 (0.18%, 95% CI: 0.02%-0.66%).…”

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confidence: 99%

“…We reviewed the English literature and found three reports on this issue [2,3,5], all of which were conducted in Japan. Patient number in each study was 155 [2], 540 [3], and 177 [5], and there has been only one patient, a 5-year-old boy [2], with FC among them.…”

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confidence: 99%

“…Central nervous system complications in Kawasaki disease (KD) have been rarely described [2,3]. However, since KD is a highly febrile, systemic vasculitis syndrome, is often accompanied with aseptic meningitis, and usually affects children under 5 years of age [1], we hypothesised that febrile convulsion (FC) may occur in a substantial proportion of KD patients.…”

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Low incidence of febrile convulsion during the acute phase of Kawasaki disease in Japan

et al. 2005

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Central nervous system complications in Kawasaki disease (KD) have been rarely described [2,3]. However, since KD is a highly febrile, systemic vasculitis syndrome, is often accompanied with aseptic meningitis, and usually affects children under 5 years of age [1], we hypothesised that febrile convulsion (FC) may occur in a substantial proportion of KD patients.To determine the incidence of FC in KD patients, we reviewed 217 KD patients (M/F: 80/137) admitted to the Nishi-Kobe Medical Centre between July 1994 and December 2004. Patient ages ranged between 1 month and 10 years with 175 (80.6%) and 206 (94.9%) subjects being £ 3 and £ 5 years of age, respectively. There was only one patient, a 1-year-8-month-old girl, with FC. Thus, the incidence of FC in our series was estimated as 0.46% (1/217).We reviewed the English literature and found three reports on this issue [2, 3,5], all of which were conducted in Japan. Patient number in each study was 155 [2], 540 [3], and 177 [5], and there has been only one patient, a 5-year-old boy [2], with FC among them. On meta-analysis of our series and these reports, the incidence was 2/ 1089 (0.18%, 95% CI: 0.02%-0.66%). When limited to patients £ 5 years of age, a predominant period for FC, this figure was somewhat higher; however, the lack of age distribution in previous studies [3,5] precluded precise determination. In any case, the incidence was unexpectedly low, compared to an epidemiological finding on the FC prevalence (8.3%) at 3 years of age in Japan [4].We found an extremely low incidence of FC in KD in Japan. This estimate, however, may not be applicable to other regions because of wide geographic differences in the prevalence of KD and FC [1,4].

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Low incidence of febrile convulsion during the acute phase of Kawasaki disease in Japan

et al. 2005

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“…In previous reports of seizures associated with Kawasaki disease (Table 1), the incidence of febrile convulsions was reported to be 1/155 1 , 8/498 2 , 1/402 3 , 0/152 4 and 0/540 5 , retrospectively. Nanbo et al .…”

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confidence: 92%

“…Although the etiology of the central nervous system involvement remains obscure, systemic vasculitis, including the central nervous system, might play a role. According to previous reports of Kawasaki disease 1−8 , seizures occur in association with meningitis or encephalitis. Febrile seizures in Kawasaki disease are considered to be extremely rare.…”

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Febrile convulsion during the acute phase of Kawasaki disease

Yoshikawa

Abe

2004

Pediatrics International

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The incidence of febrile convulsions in the acute phase of Kawasaki disease might be extremely low, confirming the results of previous reports. Kawasaki disease is characterized by systemic vasculitis and is sometimes complicated by intracranial vasculitis. The incidence of electroencephalographic abnormalities and pleocytosis in the cerebrospinal fluid is higher in patients with Kawasaki disease. However, the reason why febrile convulsions did not occur in the acute phase of Kawasaki disease remains unknown, despite the presence of central nervous system involvement.

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