Complicating Infections Associated with Common Endemic Human Respiratory Coronaviruses

Cimolai, Nevio

doi:10.1089/hs.2020.0067

Cited by 30 publications

(31 citation statements)

References 188 publications

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“…There are many anecdotes of prolonged human endemic coronavirus shedding [2,3]. Many of these findings are based on non-culture methods and detect viral genome only.…”

Section: General Attributes Of Viral Infections In the Co-infection Contextmentioning

confidence: 99%

“…Most often, the context for co-detection will be an active infection whereby the co-pathogen(s) identified is/are from the tail end of excretion due to preceding infection. Many studies of co-virus infection have not used secondary methods to confirm coronavirus detection let alone other viruses [2]. An example of the potential magnitude of this issue is illustrated by the finding in one study of a viral co-pathogen in 96% of coronavirus detections [7].…”

Section: Diagnostic Quandariesmentioning

confidence: 99%

“…Prior to SARS-CoV-2, there were many population studies throughout the world that detailed the frequency of endemic respiratory human coronaviruses and their associations with co-infection [2]. Several commonalities emerged.…”

Section: Lessons From Comparative Human Coronavirology and Co-infectionmentioning

confidence: 99%

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The Complexity of Co-Infections in the Era of COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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“…There are many anecdotes of prolonged human endemic coronavirus shedding [2,3]. Many of these findings are based on non-culture methods and detect viral genome only.…”

Section: General Attributes Of Viral Infections In the Co-infection Contextmentioning

confidence: 99%

Section: Diagnostic Quandariesmentioning

confidence: 99%

See 1 more Smart Citation

The Complexity of Co-Infections in the Era of COVID-19

Cimolai

2021

SN Compr. Clin. Med.

Self Cite

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“…All of these authorities are wary of the changing and cumulative information that is quickly arising and with which alterations to such guidelines will be incrementally made. We must certainly consider that SARS-CoV-2 could become the fifth common endemic respiratory coronavirus that will persist despite vaccination and/or widespread infection [344]. The concept of herd immunity does not necessarily impart absolute protection if the virus becomes established, but an associated mitigation for subsequent secondary illnesses is possible.…”

Section: A Model For Care?mentioning

confidence: 99%

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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“…They are globally distributed with higher incidences in winter months. Little is known about their pattern of infection, transmission rates, or duration of immunity ( 19 – 21 ). As expected, on the basis of their common phylogeny, CCC share varying degrees of sequence homology with SARS-CoV-2 and we and others have shown that cross-reactive CD4 + T cell memory responses against SARS-CoV-2 can be detected in unexposed donors ( 13 , 22 , 23 ).…”

Section: Introductionmentioning

confidence: 99%

Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers

Antunes

Pallikkuth

Williams

et al. 2021

Preprint

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Herein we measured CD4+ T cell responses against common cold corona (CCC) viruses and SARS-CoV-2 in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC reactive T cells in SARS-CoV-2 seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC reactivity was decreased in SARS-CoV-2 infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego.

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Complicating Infections Associated with Common Endemic Human Respiratory Coronaviruses

Cited by 30 publications

References 188 publications

The Complexity of Co-Infections in the Era of COVID-19

The Complexity of Co-Infections in the Era of COVID-19

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers

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