Complicated fecal microbiota transplantation in a tetraplegic patient with severeClostridium difficileinfection

Abstract

A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile (C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.

Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series

“…A case report was presented of a 65-year-old SCI patient who developed severe recurrent CDI after receiving ATB for pneumonia. Following FMT, the patient developed systemic inflammatory response syndrome and required multiple ATB treatments [ 22 ]. Our study introduces the first application of FMT to decolonize MDR organisms in the SCI population.…”

Immune Thrombocytopenia Caused by Fecal Microbial Transplantation in a Patient With Severe Recurrent Clostridium difficile Infection

“…Turbidimetric platelet aggregation is the gold standard test for evaluation of platelet function, and platelet indices, including MPV, were not correlated with the results of turbidimetric platelet aggregation. [2][3][4] Therefore, MPV should not be defined as a marker of platelet function and activity.…”

“…There is also a report of a severe systemic inflammatory response syndrome 4 days after FMT. 2 Infections including Helicobacter pylori 3 have been linked to ITP. According to the protocol approved by the Israeli Ministry of Health, the stool donor was HIV, HCV, and H. pylori negative.…”