Compliance With the Surviving Sepsis Campaign Bundle: A Multicenter Study From Turkey

Bahar, İlhan; Öksüz, Hafize; Şenoğlu, Nimet; Demirkıran, Hilmi; Aydoğan, Mustafa Said; Tomak, Yakup; Çömez, Mehmet Selim; Bayrakçı, Sinem; Gönüllü, Edip; Berktaş, Mustafa

doi:10.7759/cureus.14989

Cited by 3 publications

(6 citation statements)

References 24 publications

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“…Indeed, in a multicentre study evaluating compliance with the Surviving Sepsis Campaign Bundle in Turkey, the rate of the first one‐hour sepsis bundle protocol compliance was determined as 0%. In addition, it was determined that 40% of the patients received their first diagnosis of sepsis in >6 h, only 12% were given bolus fluids, and the median time for initial antibiotic administration was 120 min (Bahar et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…were given bolus fluids, and the median time for initial antibiotic administration was 120 min (Bahar et al, 2021).…”

Section: Nurses' Working Experiencementioning

confidence: 99%

“…In the point prevalence study conducted in 132 ICUs in 94 hospitals in Turkey, it was determined that 57.5% of the patients were infected, 10.9% had sepsis, and 13.5% had septic shock (Baykara et al, 2018). In another multicentre study (45 ICUs), it was determined that 28% of intensive care patients had sepsis and 72% had septic shock (Bahar et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Intensive care nurses’ awareness of identification of early sepsis findings

Birge

Aydın

Çamdeviren

2021

Journal of Clinical Nursing

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Aim To determine intensive care nurses’ awareness of identification of early sepsis findings. Background The incidence of sepsis is increasing in intensive care units, and if not identified early, it increases morbidity, mortality and cost of care. Intervention within one hour after the diagnosis of sepsis increases survival. Nurses’ ability to identify early findings of sepsis affects the time of diagnosis of sepsis. Design The study used a cross‐sectional design. Methods The sample of the study consisted of 544 nurses working in adult intensive care units of hospitals in Turkey. The study data were collected online between 11 January–8 April 2021 using the snowball method. Data were statically analysed. All procedures of the study adhered to the STROBE guidelines. Results The nurses who had been working for 11 years or more, had worked with a patient diagnosed with sepsis in the last month and used a measurement tool in the diagnosis thought that it was significantly easier to determine the early warning findings of sepsis. In the study, the majority of nurses correctly identified the early findings of sepsis, but the rates of the correct responses to the variables of lactate >2 mM, leucopenia and hypothermia were low. Female gender, having a graduate degree, unit type, total work experience, having received training on sepsis and working with a patient diagnosed with sepsis in the last month made a significant difference in determining the early warning findings of sepsis accurately. Conclusions Nurses had a good rate of identifying early sepsis findings. Yet, they could not distinguish between early sepsis and late sepsis findings. Relevance to clinical practice The results of the study can support nursing practices in the diagnostic process by considering the factors affecting nurses’ ability to distinguish early sepsis findings from late sepsis findings and to identify them correctly.

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Section: Discussionmentioning

confidence: 99%

“…were given bolus fluids, and the median time for initial antibiotic administration was 120 min (Bahar et al, 2021).…”

Section: Nurses' Working Experiencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intensive care nurses’ awareness of identification of early sepsis findings

Birge

Aydın

Çamdeviren

2021

Journal of Clinical Nursing

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“…Adherence to the sepsis bundle is low worldwide (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) because it requires significant medical resources to achieve adherence. Achieving a bundle in all patients with sepsis places a high burden on medical staff, so it makes sense to prioritize high-risk sepsis patients for initial resuscitation.…”

Section: Introductionmentioning

confidence: 99%

The reverse shock index multiplied by the Glasgow Coma Scale score can predict the need for initial resuscitation in patients suspected of sepsis

Matsuda

Kimura

Uemura

2023

GHM

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For patients suspected of sepsis, early recognition of the need for initial resuscitation is key in management. This study evaluated the ability of a modified shock index -the reverse shock index multiplied by the Glasgow Coma Scale score (rSIG) -to predict the need for initial resuscitation in patients with sepsis. This retrospective study involved adults with infection who were admitted to a Japanese tertiary care hospital from an emergency department between January and November 2020. The rSIG, modified Early Warning Score (MEWS), quick Sequential Organ Failure Assessment (qSOFA), and original shock index (SI) values were recorded using initial vital signs. The primary outcome was the area under the receiver-operating characteristic curve (AUROC) for the composite outcome consisting of vasopressor use, mechanical ventilation, and 72-h mortality. Secondary outcomes were the AUROCs for each component of the primary outcome and 28-day mortality. As a result, the primary outcome was met by 67 of the 724 patients (9%). The AUROC was significantly higher for the rSIG than for the other tools (rSIG 0.

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“…Sepsis is associated with high mortality and morbidity rates, reportedly between 30-50% or even higher among patients admitted in ICUs [ 1 , 2 ]. In Turkey, the mortality rates related to sepsis and septic shock in ICUs were reported to be 22% and 78%, respectively [ 3 ]. Sepsis triggers the stimulation of the factors in the complement system through the secretion of inflammatory cytokines including several interleukins (IL), tumor necrosis factor α (TNFα), and nitric oxide, resulting in a systemic inflammatory response [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Can the Reduction of Cytokines Stop the Progression of Sepsis?

Koç¹,

Çelebi²,

Hanikoglu³

et al. 2022

Cureus

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In this study, we aimed to analyze the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock. MethodsThe levels of procalcitonin (PCT) and C-reactive protein (CRP), determined to be indicators of infection/sepsis, and the levels of interleukins (IL-6, IL-8, and IL-10) and tumor necrosis factor α (TNFα), deemed as indicators of the cytokine storm, were compared among 32 patients before and after the hemadsorption procedure. ResultsThe hemadsorption significantly reduced the levels of IL-6, IL-8, IL-10, TNFα, PCT, CRP, Acute Physiology and Chronic Health Evaluation (APACHE) scores, mortality rate, and Sequential Organ Failure Assessment (SOFA) scores (p<0.05). APACHE scores and the mean predicted mortality rate (PMR) of the non-survivors measured before the procedure was significantly higher than those of survivors (p=0.002 for both). IL-10, APACHE scores, and the mortality rates determined before the hemadsorption procedure were deemed significant parameters to predict the mortality among all ICU patients (p<0.05). IL-10 levels ≤125.3 ng/L, APACHE score >30, and PMR >70.33 were significantly associated with the mortality rates of all patients, indicating that these three parameters determined before the hemadsorption may be good predictors of mortality among ICU patients with sepsis. ConclusionThe progression of sepsis in ICU patients may be prevented with cytokine hemadsorption applied as an immunomodulator therapy.

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Compliance With the Surviving Sepsis Campaign Bundle: A Multicenter Study From Turkey

Cited by 3 publications

References 24 publications

Intensive care nurses’ awareness of identification of early sepsis findings

Intensive care nurses’ awareness of identification of early sepsis findings

The reverse shock index multiplied by the Glasgow Coma Scale score can predict the need for initial resuscitation in patients suspected of sepsis

Can the Reduction of Cytokines Stop the Progression of Sepsis?

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