Compliance testing of patients in ADHD treatment with lisdexamphetamine (Elvanse®) using oral fluid as specimen

Böttcher, Michael; Kühne, David; Beck, Olof

doi:10.1016/j.clinms.2019.04.002

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Böttcher et al successfully performed chiral analysis of amphetamine in OF to differentiate between illicit intake and medication adherence to lisdexamphetamine. 44 OF is valuable in determining adherence to prescribed medications and can also be used in the field of SUD. However, OF has shorter detection windows than urine, which is a disadvantage of abstinence control screening in patients with SUDs.…”

Section: Adherence Monitoring In Oral Fluidmentioning

confidence: 99%

Sample Matrices for Mass Spectrometry–Based Adherence Monitoring: A Systematic Critical Review

Jacobs,

Wagmann,

Meyer

2023

Therapeutic Drug Monitoring

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Background: Analytical monitoring of adherence using mass spectrometry (MS) plays an important role in clinical toxicology. Unambiguous detection of drugs (of abuse) and/or their metabolites in body fluids is needed to monitor intake of medication as prescribed or to monitor abstinence as a follow-up to detoxification procedures. This study focused on the advantages and disadvantages of different sample matrices used for MS-based adherence monitoring. Methods: Relevant articles were identified through a literature search in the PubMed database. English articles published between January 01, 2017, and December 31, 2022, were selected using the keywords “adherence assess*” or “adherence monit*” or “compliance assess*” or “compliance monit*” in combination with “mass spectrom*” in the title or abstract. Results: A total of 51 articles were identified, 37 of which were within the scope of this study. MS-based monitoring was shown to improve patient adherence to prescribed drugs. However, MS analysis may not be able to assess whether treatment was rigorously followed beyond the last few days before the sampling event, except when hair is the sample matrix. For medication adherence monitoring, blood-based analyses may be preferred because reference plasma concentrations are usually available, whereas for abstinence control, urine and hair samples have the advantage of extended detection windows compared with blood. Alternative sample matrices, such as dried blood samples, oral fluid, and exhaled breath, are suitable for at-home sampling; however, little information is available regarding the pharmacokinetics and reference ranges of drug (of abuse) concentrations. Conclusions: Each sample matrix has strengths and weaknesses, and no single sample matrix can be considered the gold standard for monitoring adherence. It is important to have sufficient information regarding the pharmacokinetics of target substances to select a sample matrix in accordance with the desired purpose.

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Section: Adherence Monitoring In Oral Fluidmentioning

confidence: 99%

Sample Matrices for Mass Spectrometry–Based Adherence Monitoring: A Systematic Critical Review

Jacobs,

Wagmann,

Meyer

2023

Therapeutic Drug Monitoring

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“…org/). Thereafter the reference lists in the randomly selected studies [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] were assessed to identify new articles of interest. Articles not identified with the previous searches that fulfilled the inclusion and not the exclusion criteria, were added to the Rayyan database for further analysis.…”

Section: Eligibility Criteria Screening and Snowball Searchmentioning

confidence: 99%

Clinical Value of Emerging Bioanalytical Methods for Drug Measurements: A Scoping Review of Their Applicability for Medication Adherence and Therapeutic Drug Monitoring

Zijp

Izzah

Åberg

et al. 2021

Drugs

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“…It is only through the increased sophistication and detection capabilities of MS instruments that the microvolume DBS and VAMS sample can provide comparable data to a 1 mL blood sample. This enhanced analytical capability has also spurned the investigation of alternate less invasive biosample matrices including hair and saliva for assessing medication adherence [10,11,58,63,65,66,68,70,73,78,84,86,118,[129][130][131]. The choice of the most appropriate biosample would depend on a number of factors including the ease of sample collection from the patient and knowing if the available biosample size contains sufficient target analyte to be detected.…”

Section: Biological Sample Collectionmentioning

confidence: 99%

“…The widespread problem of medication nonadherence has fuelled interest in the application of hyphenated MS-based (predominantly LC-MS/MS [qqq]) bioanalytical assays to adherence assessment studies in other clinical areas including cancer in situations where oral chemotherapy drugs are prescribed [101][102][103][104][105][106][107][108], immunosuppressant therapy [109][110][111][112], schizophrenia [113,114], depression [115,116], epilepsy [117], asthma [118][119][120][121], infectious diseases [122,123], tuberculosis [124,125], arthritis [126,127], inflammatory bowel disease [128] and attention deficit hyperactivity disorder (ADHD) [129][130][131].…”

Section: Clinical Applications Of Hyphenated Ms Techniques For Assessmentioning

confidence: 99%

Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives

Tanna

Ogwu

Lawson

2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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Nonadherence to prescribed pharmacotherapy is an understated public health problem globally and is costing many patients their chance to return to good health and healthcare systems billions. Clinicians need an accurate assessment of adherence to medications to aid the clinical decision-making process in the event of poor patient progress and to maximise the patient health outcomes from the drug therapies prescribed. An overview of indirect and direct methods used to measure medication adherence is presented, highlighting the potential for accurate measuring of drugs in biological samples using hyphenated mass spectrometry (MS) techniques to provide healthcare professionals with a reliable evidence base for clinical decision making. In this review we summarise published applications of hyphenated MS techniques for a diverse range of clinical areas demonstrating the rise in the use of such direct methods for assessing medication adherence. Although liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods using plasma, serum and urine samples are the most popular, in recent years increased attention has been given to liquid chromatography high-resolution mass spectrometry (LC-HRMS) methods and alternative biosample matrices including hair, saliva and blood microsamples. The advantages and challenges of using hyphenated MS techniques to address this healthcare problem are also discussed alongside future perspectives.

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Compliance testing of patients in ADHD treatment with lisdexamphetamine (Elvanse®) using oral fluid as specimen

Cited by 9 publications

References 20 publications

Sample Matrices for Mass Spectrometry–Based Adherence Monitoring: A Systematic Critical Review

Sample Matrices for Mass Spectrometry–Based Adherence Monitoring: A Systematic Critical Review

Clinical Value of Emerging Bioanalytical Methods for Drug Measurements: A Scoping Review of Their Applicability for Medication Adherence and Therapeutic Drug Monitoring

Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives

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