Compliance Study of Endovascular Stent Grafts Incorporated with Polyester and Polyurethane Graft Materials in both Stented and Unstented Zones

Guan, Ying; Wang, Lu; Jing, Lin; King, Martin W.

doi:10.3390/ma9080658

Cited by 14 publications

(11 citation statements)

References 31 publications

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“…In terms of the abovementioned second (degradation should have minimal toxicity), third (the rate of degradation should match the recovery rate of vascular tissue), and fifth (mechanical behavior should meet medical stipulations) requirements, some authors have focused their studies on potentially suitable materials for producing BRS [ 7 , 8 ]. Hideo Tamai et al [ 9 ] evaluated the feasibility, safety, and efficacy of PLLA stents in humans for coronary artery stenosis with promising results.…”

Section: Introductionmentioning

confidence: 99%

3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems

et al. 2018

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Biodegradable stents (BRS) offer enormous potential but first they must meet five specific requirements: (i) their manufacturing process must be precise; (ii) degradation should have minimal toxicity; (iii) the rate of degradation should match the recovery rate of vascular tissue; (iv) ideally, they should induce rapid endothelialization to restore the functions of vascular tissue, but at the same time reduce the risk of restenosis; and (v) their mechanical behavior should comply with medical requirements, namely, the flexibility required to facilitate placement but also sufficient radial rigidity to support the vessel. Although the first three requirements have been comprehensively studied, the last two have been overlooked. One possible way of addressing these issues would be to fabricate composite stents using materials that have different mechanical, biological, or medical properties, for instance, Polylactide Acid (PLA) or Polycaprolactone (PCL). However, fashioning such stents using the traditional stent manufacturing process known as laser cutting would be impossible. Our work, therefore, aims to produce PCL/PLA composite stents using a novel 3D tubular printer based on Fused Deposition Modelling (FDM). The cell geometry (shape and area) and the materials (PCL and PLA) of the stents were analyzed and correlated with 3T3 cell proliferation, degradation rates, dynamic mechanical and radial expansion tests to determine the best parameters for a stent that will satisfy the five strict BRS requirements. Results proved that the 3D-printing process was highly suitable for producing composite stents (approximately 85–95% accuracy). Both PCL and PLA demonstrated their biocompatibility with PCL stents presenting an average cell proliferation of 12.46% and PLA 8.28% after only 3 days. Furthermore, the PCL/PLA composite stents demonstrated their potential in degradation, dynamic mechanical and expansion tests. Moreover, and regardless of the order of the layers, the composite stents showed (virtually) medium levels of degradation rates and mechanical modulus. Radially, they exhibited the virtues of PCL in the expansion step (elasticity) and those of PLA in the recoil step (rigidity). Results have clearly demonstrated that composite PCL/PLA stents are a highly promising solution to fulfilling the rigorous BRS requirements.

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Section: Introductionmentioning

confidence: 99%

3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems

et al. 2018

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“…PU graft, a tubular membrane, is used as the positive control (provided by Bose Corporation, Framingham, MA), with inner diameter of 8 mm and thickness of 0.23 ± 0.01 mm. The outer diameter and pulsatile pressure were recorded during the test period and compliance (C) was calculated according to the following equation [ 28 ]:

Where

and

are the lower and higher-pressure value (mmHg), respectively,

and

are the diameter of lower and higher pressure accordingly.…”

Section: Methodsmentioning

confidence: 99%

Development of a polycaprolactone/poly(p-dioxanone) bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment

Zhao

Sun

Xue

et al. 2021

Bioactive Materials

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Recent progress in bioresorbable stents (BRSs) has provided a promising alternative for treating coronary artery disease. However, there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease, leading to suboptimal therapy effects. Here, we developed a mechanically self-reinforced composite bioresorbable stent (cBRS) for congenital heart disease application. The cBRS consisted of poly( p -dioxanone) monofilaments and polycaprolactone/poly( p -dioxanone) core-shell composite yarns. Interlacing points in cBRS structure were partially bonded, offering the cBRS with significantly higher compression force compared to typical braids and remained good compliance. The suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing process. In addition, the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the braids. The in vivo results suggested the cBRS supported the vessel wall similar to that of metallic stent. In both abdominal aorta and iliac artery of porcine, cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month follow-up. The in vivo degradation profile of the cBRS is consistent with static degradation results in vitro. It is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the cBRS. Moreover, the lumen of cBRS implanted vessels were enlarged after 6 months, and significantly larger than the vessels implanted with metallic stent in 12 months.

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“…With this layer, blood cells adhere to the surface [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61]. A particular type of polyurethane polymer has been used as a surface coating to provide blood cell adherence [46,48,57] whereas polyester is often employed in other parts of the system such as tubular grafts [57,62,63]. Different materials, for example, ceramic (silicon nitride, zirconia, and alumina) and polymers such as ultrahigh molecular weight polyethylene, polyetheretherketone, and polyoxymethylene, have been assessed for such systems to avert wear and thrombosis [64,65].…”

Section: Design and Materials Of Blood Pumpsmentioning

confidence: 99%

Biocompatible materials of pulsatile and rotary blood pumps: A brief review

Ahmed

Wang

Yang

2020

Reviews on Advanced Materials Science

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The biomedical materials that have been used in the structure of heart pumps are classified as biocompatible, and these can be metals, polymers, ceramics, and composites. Their positions in the pump vary according to the part’s function. Whereas various materials have different properties, all biomaterials chosen for cardiovascular applications should have excellent blood biocompatibility to reduce the likelihood of hemolysis and thrombosis. There are two major categories of the heart pumps; pulsatile and rotary blood pumps (axial and centrifugal) and the features of some of these materials allow them to be used in both. Rotary and pulsatile blood pump devices have to be fabricated from materials that do not result in adverse biological responses. The purpose of this review is to study the available biocompatible materials for the pulsatile and rotary blood pumps as clinically-approved materials and prototype heart pump materials. The current state of bio-compatible materials of rotary and pulsatile blood pump construction is presented. Some recent applications of surface amendment technology on the materials for heart assist devices were also reviewed for better understanding. The limitations of heart assist devices, and the future direction of artificial heart elements have been considered. This review will be considered as a comprehensive reference to rapidly understanding the necessary research in the field of biocompatible materials of pulsatile and blood rotary pumps.

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Compliance Study of Endovascular Stent Grafts Incorporated with Polyester and Polyurethane Graft Materials in both Stented and Unstented Zones

Cited by 14 publications

References 31 publications

3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems

3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems

Development of a polycaprolactone/poly(p-dioxanone) bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment

Biocompatible materials of pulsatile and rotary blood pumps: A brief review

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