Compliance of orthopaedic patients with postoperative oral nutritional supplementation

Lawson, R. M.; Doshi, M.K.; Ingoe, Lorna; Colligan, J.M.; Barton, J R; Cobden, I

doi:10.1054/clnu.1999.0094

Cited by 55 publications

(42 citation statements)

References 10 publications

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“…Analysis of the 3-day food logs revealed that energy intake was low at baseline, averaging 1,396 and 1,546 calories consumed per day in the placebo and EAA groups, respectively. While low, others have reported similar values in older healthy (33) adults and older patient populations (34,35). However, while not significantly different between the groups 2 weeks postoperation, relative to baseline, the placebo group demonstrated greater decreases in calorie and protein intake.…”

Section: Discussionmentioning

confidence: 77%

Essential amino acid supplementation in patients following total knee arthroplasty

Dreyer¹,

Strycker²,

Senesac³

et al. 2013

J. Clin. Invest.

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Background. By the year 2030, 3.48 million older U.S. adults are projected to undergo total knee arthroplasty (TKA). Following this surgery, considerable muscle atrophy occurs, resulting in decreased strength and impaired functional mobility. Essential amino acids (EAAs) have been shown to attenuate muscle loss during periods of reduced activity and may be beneficial for TKA patients.Methods. We used a double-blind, placebo-controlled, randomized clinical trial with 28 older adults undergoing TKA. Patients were randomized to ingest either 20 g of EAAs (n = 16) or placebo (n = 12) twice daily between meals for 1 week before and 2 weeks after TKA. At baseline, 2 weeks, and 6 weeks after TKA, an MRI was performed to determine mid-thigh muscle and adipose tissue volume. Muscle strength and functional mobility were also measured at these times.Results. TKA patients receiving placebo exhibited greater quadriceps muscle atrophy, with a -14.3 ± 3.6% change from baseline to 2 weeks after surgery compared with -3.4 ± 3.1% for the EAA group (F = 5.16, P = 0.036) and a -18.4 ± 2.3% change from baseline to 6 weeks after surgery for placebo versus -6.2 ± 2.2% for the EAA group (F = 14.14, P = 0.001). EAAs also attenuated atrophy in the nonoperated quadriceps and in the hamstring and adductor muscles of both extremities. The EAA group performed better at 2 and 6 weeks after surgery on functional mobility tests (all P < 0.05). Change in quadriceps muscle atrophy was significantly associated with change in functional mobility (F = 5.78, P = 0.021).Conclusion. EAA treatment attenuated muscle atrophy and accelerated the return of functional mobility in older adults following TKA.Trial registration. Clinicaltrials.gov NCT00760383.

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Section: Discussionmentioning

confidence: 77%

Essential amino acid supplementation in patients following total knee arthroplasty

Dreyer¹,

Strycker²,

Senesac³

et al. 2013

J. Clin. Invest.

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“…Some have reported only small numbers of patients, some trials have had short treatment periods, and the outcome variables vary between the studies. The ability of elderly patients to comply with a prescribed nutritional intake varies (Lawson et al 2000, Bruce et al 2003. However, a recent Cochrane analysis concluded that total nutrient intake in geriatric patients is increased by nutritional supplementation (Milne et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Metabolism and catabolism in hip fracture patients: Nutritional and anabolic intervention—a review

2006

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“…For ONS to be effective in the management of malnutrition, patients need to consume the amount they are prescribed for the recommended period of time. However, the evidence highlights challenges in compliance in both the community and hospital settings (6,7).…”

Section: Introductionmentioning

confidence: 99%

A study in four European countries to examine the importance of sensory attributes of oral nutritional supplements on preference and likelihood of compliance

Ozcagli¹,

Stelling²,

Stanford³

2013

Turk J Gastroenterol

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Compliance of orthopaedic patients with postoperative oral nutritional supplementation

Cited by 55 publications

References 10 publications

Essential amino acid supplementation in patients following total knee arthroplasty

Essential amino acid supplementation in patients following total knee arthroplasty

Metabolism and catabolism in hip fracture patients: Nutritional and anabolic intervention—a review

A study in four European countries to examine the importance of sensory attributes of oral nutritional supplements on preference and likelihood of compliance

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