Compliance of an apatitic calcium phosphate cement with the short-term clinical requirements in bone surgery, orthopaedics and dentistry

Ginebra, Maria‐Pau; Fernández, E.; Boltong, M. G.; Bermúdez, O.; Planell, Josep A.; Driessens, F. C. M.

doi:10.1016/0267-6605(94)90018-3

Cited by 89 publications

(42 citation statements)

References 4 publications

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“…4-8 min for the initial setting time, and 10-15 min for the final setting time) [53]. The cement pastes had a good cohesion at 3 min (Figure 2), this time being shorter than the initial setting time and therefore fulfilling the clinical demands [54].…”

Section: Discussionmentioning

confidence: 97%

“…The use of cements is advantageous in comparison with sintered calcium phosphate materials, as they can be injected into the body using minimally invasive surgery techniques. However, the cement formulations must be chosen carefully to ensure a good cohesion of the paste and appropriate injectability, which will procure an adequate confinement at the target site [5,6] and clinical applicability.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Mestres

Kugiejko

Pastorino

et al. 2016

Materials Science and Engineering: C

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Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems.Consequently, the drug release pattern from the cement paste (fresh cement) is of high clinical interest.However, previous studies have commonly evaluated the drug release using pre-set cements only.Therefore, the aim of this work was to determine if the time elapsed from cement preparation until immersion in the solution (3 min for fresh cements, and 1 h and 15 h for pre-set cements) had an influence on its physical properties, and correlating these to the drug release profile. Simvastatin was selected as a model drug, while brushite cement was used as drug carrier. This study quantified how the setting of a material reduces the accessibility of the release media to the material, thus preventing drug release. A shift in the drug release pattern was observed, from a burst-release for fresh cements to a sustained release for pre-set cements.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Mestres

Kugiejko

Pastorino

et al. 2016

Materials Science and Engineering: C

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show abstract

“…10 In either case, when used as transplant materials calcium phosphate cements have been shown to be highly biocompatible. [14][15][16] Generally calcium phosphate bone substitutes are believed to be biocompatible and osteoconductive when implanted in bone defects. 1,2,4 Although some calcium phosphate biomaterials could dissolve in body fluids, cell-mediated resorption, specifically osteoclastic resorption, would be ideal for calcium phosphate biomaterials when used as bone substitutes.…”

Section: Introductionmentioning

confidence: 99%

Osteoclastic responses to various calcium phosphates in cell cultures

Doi

Iwanaga

Sendo

et al. 1999

J. Biomed. Mater. Res.

176

126

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Disks made of hydroxyapatite, beta-tricalcium phosphate, carbonate apatite, tetracalcium phosphate, alpha-tricalcium phosphate, dicalcium phosphate dihydrate, and octacalcium phosphate were incubated in osteoclastic cell cultures for 2 days. The first five salts were sintered and the last two were compressed before incubation. Osteoclasts resorbed only the sintered carbonate apatite disks. However, osteoclasts were able to resorb octacalcium phosphate disks that were preincubated for 1 day in medium without cells, indicating that surface conditioning was important for osteoclastic resorption of this calcium phosphate. Although resorption did not occur, medium calcium and phosphorus changed to an appreciable extent after a 2-day incubation of beta-tricalcium phosphate, tetracalcium phosphate, alpha-tricalcium phosphate, and dicalcium phosphate dihydrate. These changes in the medium calcium and phosphate concentrations could explain why osteoclasts appeared to have lost their activity on these calcium phosphate disks and were not capable of resorbing them. With hydroxyapatite disks no changes were observed in the medium calcium and phosphorus before and after incubation. Moreover, the osteoclasts appeared to be essentially the same as with the sintered carbonate apatite disks and with bone slices used as a control. Nevertheless, no pits or lacunae were observed on the hydroxyapatite disks, indicating that sintered carbonate apatite should be superior to sintered hydroxyapatite as a bioresorbable bone substitute.

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“…Along the study α-TCP was tested as selfsetting cementitious material, whereas β-TCP was employed as control material to discern the effect of the advancement of the setting reaction on injectability. Moreover, the role of different additives commonly used to accelerate the setting of α-TCP based cements [32][33][34] and their influence on the injectability of the pastes was analyzed: i) the incorporation of precipitated hydroxyapatite nanoparticles (pHA), used as a seed to promote heterogeneous nucleation of the precipitation product [35]; and ii) the use of a Na 2 HPO 4 solution as a liquid phase, which, based on the common ion effect [36], modifies the chemical equilibrium of eq.1, promoting the precipitation of CDHA.…”

Section: Introductionmentioning

confidence: 99%

Relevance of the setting reaction to the injectability of tricalcium phosphate pastes

2013

Self Cite

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The aim of the present work was to analyze the influence of the setting reaction on the injectability of tricalcium phosphate (TCP) pastes. Even if the injection was performed early after mixing powder and liquid, powder reactivity was shown to play a significant role in the injectability of TCP pastes. Significant differences were observed between the injection behavior of non-hardening β-TCP pastes and that of self-hardening α-TCP pastes. The differences were more marked at low liquidto-powder ratios, using fine powders and injecting through thin needles. α-TCP was in general less injectable than β-TCP and required higher injection loads. Moreover, clogging was identified as a mechanism hindering or even preventing injectability, different and clearly distinguishable from the filter-pressing phenomenon. α-TCP pastes presented transient clogging episodes, which were not observed in β-TCP pastes with equivalent particle size distribution. Different parameters affecting powder reactivity were shown to affect also paste injectability. Thus, whereas powder calcination resulted in an increased injectability due to lower particle reactivity, the addition of setting accelerants, such as hydroxyapatite nanoparticles, tended to reduce the injectability of the TCP pastes, especially if adjoined simultaneously with a Na2HPO4 solution. Although as a general trend faster setting pastes were less injectable, some exceptions were found to this rule. For example, whereas in absence of setting accelerants fine TCP powders were more injectable than the coarse ones in spite of their shorter setting times, when setting accelerants were added this trend was inverted, and coarse powders were more injectable than the fine ones. after mixing powder and liquid, powder reactivity was shown to play a significant role in the injectability of TCP pastes. Significant differences were observed between the injection behavior of non-hardening β-TCP pastes and that of self-hardening α-TCP pastes. The differences were more marked at low liquid-to-powder ratios, using fine powders and injecting through thin needles. α-TCP was in general less injectable than β-TCP and required higher injection loads. Moreover, clogging was identified as a mechanism hindering or even preventing injectability, different and clearly distinguishable from the filter-pressing phenomenon. α-TCP pastes presented transient clogging episodes, which were not observed in β-TCP pastes with equivalent particle size distribution. Different parameters affecting powder reactivity were shown to affect also paste injectability. Thus, whereas powder calcination resulted in an increased injectability due to lower particle reactivity, the addition of setting accelerants, such as hydroxyapatite nanoparticles, tended to reduce the injectability of the TCP pastes, especially if adjoined simultaneously with a Na 2 HPO 4 solution. Although as a general trend faster setting pastes were less injectable, some exceptions were found to this rule. For example, whereas in absence of sett...

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Compliance of an apatitic calcium phosphate cement with the short-term clinical requirements in bone surgery, orthopaedics and dentistry

Cited by 89 publications

References 4 publications

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Osteoclastic responses to various calcium phosphates in cell cultures

Relevance of the setting reaction to the injectability of tricalcium phosphate pastes

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