Compliance of amblyopic patients with occlusion therapy: A pilot study

Al-Zuhaibi, Sana; Al-Harthi, Iman; Cooymans, Pascale; Al-Busaidi, Aisha; Al‐Farsi, Yahya M.; Ganesh, Anuradha

doi:10.4103/0974-620x.53035

Cited by 30 publications

(14 citation statements)

References 15 publications

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“…However, others note that good outcomes are achievable with good adherence to patching in the first year of life, but lower levels thereafter (7). Adherence to occlusion therapy is likely necessary for achieving achieve good visual acuity, but adherence and visual acuity are may also likely associated because predict adherence, as patching is more difficult in children with poor vision (8). The impact of adherence to occlusion therapy on visual outcome is, therefore, difficult to assess.…”

Section: Introductionmentioning

confidence: 99%

“…The objective is to compare visual acuity in children with a unilateral congenital cataract if an intraocular lens (IOL) is implanted at the time of cataract extraction with visual acuity in children left aphakic (8). The IATS has documented that such eyes achieve a wide variety of visual outcomes, but that visual acuity at 4½ years of age does not differ by treatment group (11).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Occlusion Therapy and Optotype Visual Acuity in Children Using Data From the Infant Aphakia Treatment Study

et al. 2016

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for the Infant Aphakia Treatment Study Group IMPORTANCE Patching has been a mainstay in treating unilateral congenital cataract. However, its efficacy has not been rigorously assessed.OBJECTIVE To examine the association between patching and visual acuity in a cohort of children treated for unilateral congenital cataract. DESIGN, SETTING, AND PARTICIPANTSThis study was a secondary analysis of a randomized clinical trial (Infant Aphakia Treatment Study) of infants born from August 1, 2004, through December 31, 2008, who were treated with 1 of 2 treatments for unilateral congenital cataract and followed up to 5 years of age. Data analysis was performed from March 1, 2013, to March 1, 2016.INTERVENTIONS Cataract extraction and randomization to receipt of an intraocular lens vs being left aphakic for the first 5 years of life. MAIN OUTCOMES AND MEASURESCaregivers reported patching in the previous 48 hours in quarterly semistructured telephone interviews. The mean number of hours of patching per day was calculated from surgery to the first birthday (n = 92) and between 12 and 48 months of age (n = 102). Monocular optotype acuity was assessed at 4½ years of age by a traveling examiner using the Aphakia Treatment Study HOTV protocol. RESULTSThe Infant Aphakia Treatment Study enrolled 114 children; 57 were randomized to each treatment group. At 4½ years of age, optotype visual acuity was assessed in 112 children. The current analyses exclude an additional 3 children (2 who had adverse events that limited visual potential and 1 who had Stickler syndrome), leaving 109 total children analyzed (59 female [54.1%] and 92 white [84.4%]). Caregivers reported patching their children a mean (SD) of 3.73 (1.47) hours per day in the first year of life and 3.43 (2.04) hours per day thereafter. An association between reported patching and treatment was not identified (mean difference in first year, −0.29 hours per day; 95% CI, −0.90 to 0.33 hours per day; mean difference between 12 and 48 months of age, −0.40 hours per day; 95% CI, −1.20 to 0.40 hours per day). Visual acuity was associated with reported hours of patching in the first year of life (r = −0.32; 95% CI, −0.49 to −0.13) and between 12 and 48 months of age (r = −0.36; 95% CI, −0.52 to −0.18). However, patching accounted for less than 15% of the variance in logMAR acuity at 4½ years of age. CONCLUSIONS AND RELEVANCEThese results support the association of occlusion throughout the preschool years with improved visual acuity in infants treated for unilateral congenital cataract. However, similar visual outcomes were achieved with varying amounts of patching. These conclusions should be interpreted in the context of limitations related to generalizability from incomplete data collected in a clinical trial. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00212134

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between Occlusion Therapy and Optotype Visual Acuity in Children Using Data From the Infant Aphakia Treatment Study

et al. 2016

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“…According to a study conducted by Al-Zuhaibi et al . suggested that with bad treatment compliance affect success chance in treating amblyopia, with increase of visual acuity was strongly associated with treatment compliance in occlusion therapy (p = 0.08) [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Visual Acuity Improvement in Continuous vs Divided Occlusion in Anisometropic Amblyopia

Irfani

Feriyanto

Oktarima

et al. 2018

TOOPHTJ

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Purpose:To compare visual acuity improvement between continuous and split part-time occlusion for the treatment of moderate and severe anisometropic amblyopia.Methods:Randomised clinical trials in 6 – 13 y.o children with moderate and severe anisometropic amblyopia. Each patient was consecutively selected with continuous or split part-time occlusion. Best corrected visual acuity’s improvement was followed up to six weeks and statistical data were analyzed using chi square and unpaired t-test.Results:Best corrected visual acuity’s improvement was comparable between continuous and split part-time occlusion (0.20±0.27 vs 0.21±0.25; p = 0.79).Conclusion:Split part-time occlusion may be considered as an alternative treatment for moderate and severe anisometropic amblyopia treatment.

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“…Although occlusion is a standard part of treatment, its efficacy has not been rigorously assessed [3]. Further, because occlusion is often difficult for caregivers to administer [4, 5], there is a high-level of non-concordance between prescribed and achieved occlusion [6–11]. Thus, the ability to assess adherence to occlusion therapy is important for clinicians caring for, as well as researchers.…”

Section: Introductionmentioning

confidence: 99%

“…The assessment of adherence has utilized qualitative parental questionnaires [4, 6, 7, 10] parental report combined with attendance at clinic visits [12], diaries and recall interviews [8, 13], and occlusion dose monitors (ODMs) [14–18]. ODMs have the potential advantage of providing quantitative data [14–16, 18, 19] and have been successfully used over short periods of time (e.g., <6 months) in older children.…”

Section: Introductionmentioning

confidence: 99%

Assessment of adherence to visual correction and occlusion therapy in the Infant Aphakia Treatment Study

Drews‐Botsch

Cotsonis

Celano

et al. 2016

Contemporary Clinical Trials Communications

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Occlusion therapy throughout early childhood is believed to be efficacious in treating deprivation amblyopia but has not been rigorously assessed in clinical trials. Further, tools to assess adherence to such therapy over an extended period of time are lacking. Using data from the Infant Aphakia Treatment Study, a randomized clinical trial of treatment for unilateral congenital cataract, we examined the use of quarterly 48-hour recall interviews and annual 7-day prospective diaries to assess reported hours of patching in 114 children throughout the first 5 years of life. Consistency of data reported was assessed using correlation coefficients and intraclass correlation coefficients. Both interview and diary data showed excellent consistency with Cronbach’s Alpha’s ranging from 0.69 to 0.88 for hours of patching and 0.60 to 0.73 for hours of sleep. However, caregivers reported somewhat more adherence in prospective diaries than retrospective interviews. Completion rates, on the other hand, were substantially higher for telephone interviews than prospective diaries. For example, after four years of surgery response rates to telephone interviews exceeded 75% versus completion rates of only 54% for diaries. In situations where occlusion dose monitors cannot be used for assessing adherence to occlusion therapy, such as in infants or over an extended period of time, quantitative assessments of occlusion therapy can be obtained by parental report, either as a series of prospective diaries or a series of recall interviews.

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Compliance of amblyopic patients with occlusion therapy: A pilot study

Cited by 30 publications

References 15 publications

Association Between Occlusion Therapy and Optotype Visual Acuity in Children Using Data From the Infant Aphakia Treatment Study

Association Between Occlusion Therapy and Optotype Visual Acuity in Children Using Data From the Infant Aphakia Treatment Study

Visual Acuity Improvement in Continuous vs Divided Occlusion in Anisometropic Amblyopia

Assessment of adherence to visual correction and occlusion therapy in the Infant Aphakia Treatment Study

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