Compliance from Self-Reported versus Pharmacy Claims Data with Metered-Dose Inhalers

Erickson, Steven R.; Coombs, John; Kirking, Duane M.; Azimi, Anita R

doi:10.1345/aph.10379

Cited by 107 publications

(78 citation statements)

References 12 publications

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“…For example, it was used or adapted for use in studies of participants with hypertension (McNagny, Ahluwalia, Clark, & Resnicow, 1997;Shea, Misra, Ehrlich, Field, & Francis, 1992), HIV (Corless et al, 2005;Gao & Nau, 2000;Knobel et al, 2002;Pratt et al, 2001), psychoses (Thompson, Kulkarni, & Sergejew, 2000), diabetes (Krapek et al, 2004;Venturini et al, 1999), cancer pain (Chang, Chang, Chiou, Tsou, & Lin, 2002), cardiac problems (Shalansky, Levy, & Ignaszewski, 2004), mood disorders (C. F. George, Peveler, Heiliger, & Thompson, 2000), osteoporosis (Turbi et al, 2004), thromboembolic disease (N. J. Davis, Billett, Cohen, & Arnsten, 2005), and asthma (Erickson, Coombs, Kirking, & Azimi, 2001). …”

Section: The Medication Adherence Questionnairementioning

confidence: 99%

Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit

Toll

McKee

Martin

et al. 2007

CNTR

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The Medication Adherence Questionnaire (MAQ) is a scale used to evaluate adherence to medications. The present study assessed the factor structure and validity of the MAQ with cigarette smokers. A principal components analysis was conducted on MAQ scores from a sample of smokers presenting for treatment in a clinical trial of naltrexone and nicotine patch for smoking cessation (N=385). Indices of convergent and predictive validity were tested using electronic medication caps for naltrexone, nicotine patch counts, plasma drug levels of naltrexone, and treatment outcomes. The principal components analysis revealed two factors. Factor 1, labeled "unintentional nonadherence," measured the extent to which individuals were nonadherent because they were careless or forgot to take their medications. Factor 2, labeled "purposeful nonadherence," assessed nonadherence related to purposefully stopping medication use after feeling better or worse. Only the second factor was shown to have good convergent and predictive validity. Specifically, this factor was related to pilltaking behavior measured with electronic medication caps and drug plasma levels and nicotine patch use based on nicotine patch count data, and it was associated with smoking cessation outcome. Thus the purposeful nonadherence factor of the MAQ may be used as a brief screening tool for medication adherence with cigarette smokers seeking treatment. Information obtained with this questionnaire could be used to counsel patients regarding the importance of medication adherence.

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Section: The Medication Adherence Questionnairementioning

confidence: 99%

Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit

Toll

McKee

Martin

et al. 2007

CNTR

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“…In the present study using a valid qualitative methodology, a total of 12 conditions or barriers to the use of inhalers, which have been related to the control of respiratory diseases in previous studies, (29)(30)(31)(32) were formed by a consensus of a large group of health care professionals and thereupon, in a large sample of patients. Questionnaires available up to date (8)(9)(10)29) have also assessed some conditions included in the TAI, although in a partial way including forgetfulness, lack of need of inhaler use, side effects-related concern and availability of the inhaler.…”

Section: Discussionmentioning

confidence: 99%

Validation of the 'test of the adherence to inhalers' (TAI) for asthma and COPD patients

Gutiérrez-Pereyra

Plaza

Fernández-Rodríguez

et al. 2015

1.11 Clinical Problems - Asthma

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Background: To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. Methods: A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ‡80% were defined as adherents. Construct validity, internal validity, and criterion validity were evaluated. Self-reported adherence was compared with the Morisky-Green questionnaire.Results: Factor analysis study demonstrated two factors, factor 1 was coincident with TAI patient domain (items 1 to 10) and factor 2 with TAI health-care professional domain (items 11 and 12). The Cronbach's alpha was 0.860 and the test-retest reliability 0.883. TAI scores correlated with electronic adherence (q¼0.293, p¼0.01). According to the best cut-off for 10 items (score 50, area under the ROC curve 0.7), 569 (62.5%) patients were classified as nonadherents. The non-adherence behavior pattern was: erratic 527 (57.9%), deliberate 375 (41.2%), and unwitting 242 (26.6%) patients. As compared to Morisky-Green test, TAI showed better psychometric properties. Conclusions: The TAI is a reliable and homogeneous questionnaire to identify easily non-adherence and to classify from a clinical perspective the barriers related to the use of inhalers in asthma and COPD.

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“…An objective measure of refills was expressed as the number of days' supply during the 6 months reference period (refill frequency × the number of doses per inhaler/number of doses per day based on assumed dose)/number of days in the reference period (13). As defined in previous reports, patients were classified as having good adherence to the inhalation regimen if the refill rate was ≥80%, whereas a rate <80% indicated non-adherence (13,23).…”

Section: Pharmacy-refill Datamentioning

confidence: 99%

“…As defined in previous reports, patients were classified as having good adherence to the inhalation regimen if the refill rate was ≥80%, whereas a rate <80% indicated non-adherence (13,23).…”

Section: Pharmacy-refill Datamentioning

confidence: 99%

“…Therefore, the Global Initiative for Asthma (GINA) stated that follow-up consultations including assessment of patients' medication adherence and evaluation of inhaler device technique should occur at regular intervals (7). Currently, a variety of methods exist to assess adherence including medication counting (8,9), diaries, electronic monitors (10,11), questionnaires (12)(13)(14), and analysis of pharmacy claims databases (15)(16)(17). Some simple selfreported adherence questionnaires have been previously studied (12,18,19).…”

Section: Introductionmentioning

confidence: 99%

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Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

Takemura¹,

Nishio²,

Fukumitsu³

et al. 2017

J. Thorac. Dis.

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Background: Non-adherence to inhalation regimens is common in asthmatic patients. The Adherence Starts with Knowledge-12 (ASK-12) survey was developed to detect and address patient-specific barriers to medication adherence. Our objective is to investigate the clinical usefulness of the ASK-12 for assessing and addressing adherence to inhalation therapy in asthma. Methods: The ASK-12 was administered to 138 asthmatic patients. Using pharmacy-refill data, we examined the cut-off value of the ASK-12 to identify patients who were non-adherent to inhalation regimens and identify factors associated with non-adherence. To verify the usefulness of the ASK-12, inhalation regimens were prospectively switched to less-expensive and simpler (once-daily) dosing regimens in eight non-adherent asthmatic patients who reported specific-barriers in "inconvenience of twice-daily inhaler use" and "cost".Results: Valid responses were received from 114 (82.6%) patients. A significant correlation was found between pharmacy-refill rates and the ASK-12 total score (r=−0.55, P<0.0001). The optimal cut-off value of the ASK-12 total score to discriminate non-adherent patients (defined by pharmacy-refill rate <80%) was 23, with 71.4% specificity and 93.3% sensitivity. Using this value, 52 (45.6%) patients were classified as nonadherent. Univariate followed by multivariate analysis identified younger age as a predictor of non-adherence to inhalation regimens (odds ratio, 2.67; 95% CI, −0.95 to −0.06; P=0.027). Switching inhaled medicines in eight patients resulted in significant improvements in both ASK-12 scores and asthma control. Conclusions:The ASK-12 is a brief, practical, and clinically useful measure for assessing and addressing adherence to inhalation regimens in asthma.

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Compliance from Self-Reported versus Pharmacy Claims Data with Metered-Dose Inhalers

Abstract: This study demonstrated a moderate correlation between self-reported asthma compliance and the compliance ratio determined using claims data. The questionnaire may be useful as a screening tool to detect noncompliant behavior in populations or individual patients with asthma.

Cited by 107 publications

References 12 publications

Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit

Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit

Validation of the 'test of the adherence to inhalers' (TAI) for asthma and COPD patients

Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

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