Compliance as a factor effecting the patency of a copolyurethane vascular graft

Lyman, Donald J.; Fazzio, F. J.; Voorhees, H.; Robinson, Graham J.; Albo, Dominic

doi:10.1002/jbm.820120307

Cited by 90 publications

(31 citation statements)

References 3 publications

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“…[11][12][13][14][15] For example, compliance mismatch between a vascular graft and the native vessel into which it is implanted has been demonstrated to be a critical factor, leading at times to the formation of neointimal hyperplasia and stenosis. 16,17 The biomechanical properties of a TEVG are determined primarily by the sum of the mechanical properties of the scaffold and the biomechanical properties of the ECM. In the case of a biodegradable scaffold, this process is dynamic and changes as the scaffold degrades and neotissue forms.…”

mentioning

confidence: 99%

Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model

Naito

Lee

et al. 2014

Tissue Engineering Part A

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We previously developed and validated a murine model for investigating neotissue formation in tissueengineered vascular grafts (TEVGs). Herein, we present the first longitudinal assessment of both the microstructural composition and the mechanical properties of a TEVG through the process of neovessel formation (total scaffold degradation). We show that when (poly)glycolic acid-based biodegradable scaffolds were used as inferior vena cava interposition grafts in mice, the evolving neovessel developed biaxial properties that approached those of the native vein within 24 weeks of implantation. Further, we found that these changes in biaxial properties related temporally to extracellular matrix production and remodeling, including deposition of collagen (types I and III), elastic fibers (elastin and fibrillin-1), and glycosaminoglycans in addition to changes in matrix metalloproteinase (MMP)-2 and -9 activity. Improving our understanding of the mechanobiological principles underlying vascular neotissue formation in TEVGs holds great promise for improving the design of TEVGs and enabling us to continue the translation of this technology from the bench to the clinic.

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mentioning

confidence: 99%

Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model

Naito

Lee

et al. 2014

Tissue Engineering Part A

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“…10 Most polymeric vascular prostheses have a material compliance greatly exceeding that of the natural vessel. Lyman et al 11,12 reported that a mismatch in material compliance between the polymer and the vessel initiates thrombosis and stimulates initial intimal hypertrophy. For many diseases of the sclera, such as pathologic myopia, the compliance of the diseased sclera is much higher than that of normal sclera.…”

Section: Discussionmentioning

confidence: 99%

Synthetic scleral reinforcement materials. III. Changes in surface and bulk physical properties

Jacob

Lin

Mikal

1997

J. Biomed. Mater. Res.

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Changes in the physical properties of polymer materials during implantation in the biological environment can directly affect the ultimate performance of the polymer and/or device. We implanted four types of extraocular bands (porous, solid, composite, and patched) made from 11 types of materials in rabbit eyes and examined the changes in the physical strength and polymer structure of the implanted bands in terms of tensile strength measurements, creep analysis, and attenuated total internal reflectance--Fourier transform infrared spectroscopy (ATR-FTIR) at intervals up to 18 months after implantation. Most of the materials showed increases in tensile strength over the first 6 months in situ in the rabbit eye, followed by significant decreases between 6 and 18 months. Polymer bands that had been implanted for 18 months generally exhibited less creep behavior than unimplanted controls; for most of the bands, creep values ranged from 0% to 10% of the original length. ATR-FTIR of the solid bands and surface coatings showed protein deposition on all of the materials examined, with silicone materials and coatings least affected. Thirty-degree ATR-FTIR scans detected significant changes in the polymer structure for two of the band types: one solid (polyether urethane) and one porous (porous polyacrylate). In general, expanded polytetrafluoroethylene was the most stable in terms of tensile strength and creep. The least stable bands (composite bands made with porous polyurethane) were those that had undergone hydrolytic and/or oxidative degradation and chain scission of the polymer or alteration of the bond between the two materials making up the composite. These changes in physical properties and polymer structure observed after 18 months of implantation support the idea that polymer implant materials should be followed closely over several years in vivo to determine their suitability prior to use in humans.

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“…Molded specimens (2 Â 10 Â 20 mm 3 ) were cut in the half with a knife (to avoid edge effects), provided with a seam of surgical suture (PP monofilament, suture size 6-0-0.07 mm in diameter) by the aid of a special gauge (seam distance 4 mm from the edge), clasped into a modified tensile testing arrangement (Figure 3 left) and loaded with a speed of 1 mm/min. A typical curve of the tear resistance test is shown in Figure 3 right.…”

Section: Suture Tear Resistance Testsmentioning

confidence: 99%

“…[3] Therefore, we are interested in the development of suitable blood vessel substitutes out of biocompatible, mechanically tailorable photopolymers. We designed our resin formulation to be suitable for rapid prototyping which offers us the high range of shaping possibilities of additive manufacturing (AM).…”

Section: Introductionmentioning

confidence: 99%

Photopolymerizable Elastomers for Vascular Tissue Regeneration

Baudis

Steyrer

Pulka

et al. 2010

Macromolecular Symposia

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Summary: The aim of this study was to design new resin formulations for blood vessel substitutes with small inner diameter that can be 3D-printed by Additive Manufacturing (AM). Commercially available urethane oligomer acrylates as crosslinking agents (CAs) with different reactive diluents (RDs) and/or thiol chain transfer agents (CTAs) were examined. It could be shown that the properties of photopolymers of carefully selected CA/RD/CTA combinations can be varied in a wide range, also to fit with those of natural blood vessels. Moreover, these materials showed good biocompatibility in in-vitro cell culture tests with endothelial cells. A new method to assess the tear resistance of the new materials in comparison with natural blood vessels was designed and established. The tear resistance of the developed photopolymers already approaches those of natural material, although there is still need of improvement. The 3D-structuring of optimized resin system succeeded. Hence AM has proven to be an ideal tool to manufacture parts with the complex structure of natural blood vessels.

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Compliance as a factor effecting the patency of a copolyurethane vascular graft

Cited by 90 publications

References 3 publications

Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model

Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model

Synthetic scleral reinforcement materials. III. Changes in surface and bulk physical properties

Photopolymerizable Elastomers for Vascular Tissue Regeneration

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