Compliance and Airway Resistance During Anaesthesia With Controlled Ventilation

Norlander, O.; Herzog, P.; NORD??N, I.; Hossli, G; Schaer, H; Gattiker, R.

doi:10.1097/00132586-197002000-00002

Cited by 4 publications

(4 citation statements)

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“…We also found that inspiratory pulmonary resistance was almost doubled by the induction of anaesthesia and IPPV (Clements et al, 1959;Westgate, Gordon and Van Bergen, 1962;Norlander et al, 1968;Hedstrand, 1970). This increase was not significantly altered by changing the frequency of ventilation (Hedenstierna and Lofstrom, 1972).…”

Section: Discussionmentioning

confidence: 62%

Mechanics of Breathing, Gas Distribution and Functional Residual Capacity at Different Frequencies of Respiration During Spontaneous and Artificial Ventilation

Hedenstierna¹,

McCarthy²

1975

British Journal of Anaesthesia

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Nine healthy volunteers were investigated, both while awake and breathing spontaneously, and while anaesthetized with IPPV, in all cases at rates of both 12 and 24 b.p.m. Gas flow and volume were measured with a pneumotachography. The transpulmonary pressure (the pressure difference between the trachea or the buccal cavity and the oesophagus) was also recorded. The distribution of gas was analysed by means of nitrogen washout curves, which also permitted the determination of functional residual capacity (FRC). Lung compliance during IPPV was approximately half that during spontaneous breathing. During IPPV the compliance was dependent on the frequency of ventilation, being lower with the greater frequency. Pulmonary resistance was approximately twice as great with artificial ventilation, but no significant relationship to frequency was demonstrated. Gas distribution was within normal limits and in this respect there was no difference between low and high rates of spontaneous breathing. With IPPV at the higher rate, gas distribution was significantly less even, but still within normal limits. Dfferences in FRC under the different conditions during the experiments were not significant, but the values obtained were lower with artificial ventilation. Neither the reduction in dynamic lung compliance induced by anaesthesia and artificial ventilation, nor its dependence on the frequency of such ventilation, can be explained with certainty by changes in gas distribution.

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Section: Discussionmentioning

confidence: 62%

Mechanics of Breathing, Gas Distribution and Functional Residual Capacity at Different Frequencies of Respiration During Spontaneous and Artificial Ventilation

Hedenstierna¹,

McCarthy²

1975

British Journal of Anaesthesia

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“…In later studies Sykes and coworkers showed that most inhalational anaesthetics attenuate hypoxic vasoconstriction. 8 Bjertnaes, on the other hand, found that intravenous barbiturates did not reduce hypoxic vasoconstriction. '9 Results vary, however, presumably because of confounding factors obscuring the hypoxic vasoconstriction response.20 It should also be stressed that attenuation of hypoxic vasoconstriction does not cause impairment of the gas exchange unless an underlying disturbance of lung function causing a lowered Pao2 is present.…”

Section: Hypoxic Pulmonary Vasoconstrictionmentioning

confidence: 97%

Contribution of multiple inert gas elimination technique to pulmonary medicine. 6. Ventilation-perfusion relationships during anaesthesia.

Hedenstierna¹

1995

Thorax

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“…Tracheal pressure (PT) was measured by connecting a polyethylene catheter inserted into the tracheal tube to a differential transducer, in which one arm opened to the atmosphere. R L and Cay n were calculated using a manual graphic method reported by Norlander et al [25].…”

Section: Introductionmentioning

confidence: 99%

Effects of vagal stimulation on slowly adapting pulmonary stretch receptors and lung mechanics in anesthetized rabbits

Matsumoto

1996

Lung

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An in vivo preparation was designed to investigate the effect of vagus nerve stimulation-induced bronchoconstriction on the relationship of slowly adapting pulmonary stretch receptor (SAR) activity and lung mechanics. SAR activities were recorded from the left vagus nerve. The responses of SARs, total lung resistance (RL), and dynamic lung compliance (Cdyn) to electrical stimulation of the peripheral end of the cut right vagus nerve (10-15 V, 5-30 Hz, 0.2 ms) were examined before atropine and 5 and 10 min after atropine (2 mg/kg) in anesthetized, artificially ventilated, bilaterally vagotomized rabbits. In the time course profile during vagal stimulation, an increase in RL and a decrease in Cdyn occurred simultaneously, and these opposite changes were frequency dependent. The average responses of SAR activity, RL, and Cdyn to vagal stimulation became more pronounced as the frequencies of the stimulation were increased. The responses obtained during vagal stimulation (5-30 Hz) were blocked or diminished greatly by the administration of atropine. Repeated vagus nerve stimulation in the presence of atropine did not show any significant change in SAR activity and lung mechanics. These results suggest that changes of SAR activity, RL, and Cdyn induced by vagal stimulation occur as a result of smooth muscle contraction in the airways, which is mediated mainly by muscarinic receptor activation and which is not involved in the release of neurotransmitters to relax airway smooth muscle.

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Compliance and Airway Resistance During Anaesthesia With Controlled Ventilation

Cited by 4 publications

References 0 publications

Mechanics of Breathing, Gas Distribution and Functional Residual Capacity at Different Frequencies of Respiration During Spontaneous and Artificial Ventilation

Mechanics of Breathing, Gas Distribution and Functional Residual Capacity at Different Frequencies of Respiration During Spontaneous and Artificial Ventilation

Contribution of multiple inert gas elimination technique to pulmonary medicine. 6. Ventilation-perfusion relationships during anaesthesia.

Effects of vagal stimulation on slowly adapting pulmonary stretch receptors and lung mechanics in anesthetized rabbits

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