Complexometric Titration of Aluminum and Magnesium Ions in Commercial Antacids. An Experiment for General and Analytical Chemistry Laboratories

Yang, Shiliang; Tsai, Ruei Ying

doi:10.1021/ed083p906

Cited by 25 publications

(19 citation statements)

References 9 publications

(9 reference statements)

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“…While this system only addresses the titration aspects of the experiment, assistance is still required for equipment setup, volume measurements, and dilution. Furthermore, with a few modifications it is possible to adapt this titration setup to other undergraduate experiments, such as potentiometric titration, conductometric titration, and complexometric titration. − For example, conductometric titration can be performed via connecting a conductivity electrode to the analog port of the Arduino . As for potentiometric titration, construction of a potentiostat is required, and instructions for this can be found elsewhere .…”

Section: Discussionmentioning

confidence: 99%

Rethinking a Timeless Titration Experimental Setup through Automation and Open-Source Robotic Technology: Making Titration Accessible for Students of All Abilities

et al. 2019

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Titration is a common introductory experiment performed across teaching laboratories from high school to university. Yet, its setup remains inaccessible for students with disabilities, denying them the opportunity for experiential learning. Therefore, rethinking such a setup is required to increase laboratory participation for these students.To remove these physical barriers, an automated titration unit based on existing undergraduate titration setups and universal design concepts, coupled with text-to-speech (TTS) capability, is presented. This unit can connect seamlessly via Bluetooth to any mobile platform and takes advantage of the advances in assistive features, such as TTS, on either a tablet or a smartphone. The cost of this unit is between $300 and $500, not including the cost of the smartphone or tablet. However, with the popularity of mobile devices in our society, these devices are becoming highly affordable, and almost every undergraduate is equipped with such a device. Also, with the emphasis on coding literacy, this autotitration setup serves as an excellent example and exercise on design thinking and automation in an undergraduate chemistry lab.

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Section: Discussionmentioning

confidence: 99%

Rethinking a Timeless Titration Experimental Setup through Automation and Open-Source Robotic Technology: Making Titration Accessible for Students of All Abilities

et al. 2019

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“…Then, the plates were overlayed with 100 µL (96-well plates) or 500 µL (24-well plates) of cell suspension (20 × 10 3 cells/mL). In the third PBS washing solution, the Mg 2+ concentration was determined by complexometric titration [ 81 ]. Less than 1 mM Mg 2+ was detected.…”

Section: Methodsmentioning

confidence: 99%

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

et al. 2020

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The mucus layer of the nasopharynx and bronchial epithelium has a barrier function against inhaled pathogens such as the coronavirus SARS-CoV-2. We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing polymer released from blood platelets, blocks the binding of the receptor binding domain (RBD) to the cellular ACE2 receptor in vitro. PolyP is a marine natural product and is abundantly present in marine bacteria. Now, we have approached the in vivo situation by studying the effect of polyP on the human alveolar basal epithelial A549 cells in a mucus-like mucin environment. These cells express mucins as well as the ectoenzymes alkaline phosphatase (ALP) and adenylate kinase (ADK), which are involved in the extracellular production of ATP from polyP. Mucin, integrated into a collagen-based hydrogel, stimulated cell growth and attachment. The addition of polyP to the hydrogel significantly increased cell attachment and also the expression of the membrane-tethered mucin MUC1 and the secreted mucin MUC5AC. The increased synthesis of MUC1 was also confirmed by immunostaining. This morphogenetic effect of polyP was associated with a rise in extracellular ATP level. We conclude that the nontoxic and non-immunogenic polymer polyP could possibly also exert a protective effect against SARS-CoV-2-cell attachment; first, by stimulating the innate antiviral response by strengthening the mucin barrier with its antimicrobial proteins, and second, by inhibiting virus attachment to the cells, as deduced from the reduction in the strength of binding between the viral RBD and the cellular ACE2 receptor.

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“…4,[25][26][27][28] EDTA has been used to analyze almost half of the elements in the periodic table while its derivatives such as diethylene triamine pentaacetic acid (DTPA) and ethylene glycol tetraacetic acid (EGTA) provide similar usage. 4,[29][30][31][32][33][34][35][36][37] EDTA and its derivatives belong to the aminopolycarboxylic acid family. It is able to dissociate into several protonation states.…”

Section: The Classical Chelator Edtamentioning

confidence: 99%

Complexometric titrations: new reagents and concepts to overcome old limitations

Zhai

Bakker

2016

Analyst

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Chelators and end point indicators are the most important parts of complexometric titrations. The most widely used universal chelator ethylenediamine tetraacetic acid (EDTA) and its derivatives can strongly coordinate with different metal ions. Their limited selectivity often requires the use of masking agents, and the multiple pKa values of the chelators necessitate a careful adjustment of pH during the procedure. Real world requirements for pH independent, selective and sensitive chelators and indicators call for a new design of these reagents. New concepts and structures of chelators and indicators have indeed recently emerged. We present here recent developments on chelators and indicators for complexometric titrations. Many of these advances were made possible only recently by moving the titration from a homogeneous to a heterogeneous phase using a new class of chelators and indicators based on highly selective ionophores embedded in ion-selective nanosphere emulsions. In view of achieving titrations in situ by complete instrumental control, thin layer electrochemistry has recently been shown to be an attractive concept that replaces the traditional cumbersome titration protocol with a direct reagent free sensing tool.

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Complexometric Titration of Aluminum and Magnesium Ions in Commercial Antacids. An Experiment for General and Analytical Chemistry Laboratories

Cited by 25 publications

References 9 publications

Rethinking a Timeless Titration Experimental Setup through Automation and Open-Source Robotic Technology: Making Titration Accessible for Students of All Abilities

Rethinking a Timeless Titration Experimental Setup through Automation and Open-Source Robotic Technology: Making Titration Accessible for Students of All Abilities

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

Complexometric titrations: new reagents and concepts to overcome old limitations

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