This retrospective study quantifies the relative contribution of age and sex as demographic factors, comorbidity, education and occupation as cognitive reserve (CR) proxies in accounting for cognitive aging. Participants underwent three neuropsychological evaluations, with their cognitive profiles being classified as unimpaired, mildly or severely impaired. For all 3,081 participants, in addition to age, education was the best predictor of performance followed by occupation. From the original sample, 543 participants were reassessed a second time, and 125 a third time. Depending on whether they maintained or worsened their profile based on their initial performance, participants were classified as resistant or declining. Results showed that, across assessments, the resistant had higher levels of education and occupation than the declining. Education and occupation modulated cognitive performance also in the more severely impaired group. This study confirms that the trajectories of changes of performance in ageing are consistently predicted by high levels of CR.