Complexity of seemingly simple lipid nanodiscs

Stępień, Piotr; Augustyn, Bozena; Poojari, Chetan; Galan, Wojciech; Polit, Agnieszka; Vattulainen, Ilpo; Wisnieska-Becker, Anna; Róg, Tomasz

doi:10.1016/j.bbamem.2020.183420

Cited by 26 publications

(17 citation statements)

References 65 publications

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“…Long and short distances are separated for clarity. Nanodiscs, long 28 Å [27][28][29][30] and short 21 Å [20][21][22]. Amphipols, long 24 Å [22][23][24][25][26] and short 18 Å [16][17][18][19][20].…”

Section: Fig 2 Distance Distributions Between the Protein Edge And The Belt Boundarymentioning

confidence: 99%

“…Nanodiscs, long 28 Å [27][28][29][30] and short 21 Å [20][21][22]. Amphipols, long 24 Å [22][23][24][25][26] and short 18 Å [16][17][18][19][20]. Detergents, long 27 Å [26][27][28] and short 21 Å [20][21][22].…”

Section: Fig 2 Distance Distributions Between the Protein Edge And The Belt Boundarymentioning

confidence: 99%

“…Amphipols, long 24 Å [22][23][24][25][26] and short 18 Å [16][17][18][19][20]. Detergents, long 27 Å [26][27][28] and short 21 Å [20][21][22]. B/ All distances represented by a grey dot.…”

Section: Fig 2 Distance Distributions Between the Protein Edge And The Belt Boundarymentioning

confidence: 99%

“…This layer is a belt from which membrane proteins are indissociable. Importantly, all these environments bear intrinsic variability in size and shape as measured by various methods, alone or in complex with membrane proteins [18,[20][21][22]. Also, some environments like detergents are thought to be more fluid and displaying intrinsic variability [4] than more rigid ones like amphipols, know to stabilize membrane proteins for example [13].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer

Zampieri

Gobet

Robert

et al. 2021

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Section: Fig 2 Distance Distributions Between the Protein Edge And The Belt Boundarymentioning

confidence: 99%

Section: Fig 2 Distance Distributions Between the Protein Edge And The Belt Boundarymentioning

confidence: 99%

Section: Fig 2 Distance Distributions Between the Protein Edge And The Belt Boundarymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer

Zampieri

Gobet

Robert

et al. 2021

Biochimica et Biophysica Acta (BBA) - Biomembranes

View full text Add to dashboard Cite

“…Use of nanodiscs for simultaneous delivery of antigen and adjuvant has been found to increase the response of the immunological system by orders of magnitude in comparison to traditional vaccines. Due to the variety of possible applications of nanodiscs, their properties are the subject of intensive study (Debnath and Schäfer, 2015;Siuda and Tieleman, 2015;Stepien et al, 2015Stepien et al, , 2020Martinez et al, 2017;Pourmousa and Pastor, 2018;Bengtsen et al, 2020;Schachter et al, 2020); they are tuned via modification of their lipid composition (Augustyn et al, 2019) or alterations to the sequence, thus structure, of the scaffold proteins (Denisov et al, 2004;Nasr et al, 2016).…”

Section: Nanomedicinementioning

confidence: 99%

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery

Bunker

Róg

2020

Front. Mol. Biosci.

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In this review, we outline the growing role that molecular dynamics simulation is able to play as a design tool in drug delivery. We cover both the pharmaceutical and computational backgrounds, in a pedagogical fashion, as this review is designed to be equally accessible to pharmaceutical researchers interested in what this new computational tool is capable of and experts in molecular modeling who wish to pursue pharmaceutical applications as a context for their research. The field has become too broad for us to concisely describe all work that has been carried out; many comprehensive reviews on subtopics of this area are cited. We discuss the insight molecular dynamics modeling has provided in dissolution and solubility, however, the majority of the discussion is focused on nanomedicine: the development of nanoscale drug delivery vehicles. Here we focus on three areas where molecular dynamics modeling has had a particularly strong impact: (1) behavior in the bloodstream and protective polymer corona, (2) Drug loading and controlled release, and (3) Nanoparticle interaction with both model and biological membranes. We conclude with some thoughts on the role that molecular dynamics simulation can grow to play in the development of new drug delivery systems.

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Phospholipid-based nano drug delivery system of curcumin using MSP1D1 protein and poloxamer 407: a comparative study for targeted drug delivery to the brain

Shariare,

Mannan,

Khan

et al. 2024

J Nanopart Res

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Complexity of seemingly simple lipid nanodiscs

Cited by 26 publications

References 65 publications

CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer

CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery

Phospholipid-based nano drug delivery system of curcumin using MSP1D1 protein and poloxamer 407: a comparative study for targeted drug delivery to the brain

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