Complexity of CEBPA Dysregulation in Human Acute Myeloid Leukemia

Pabst, Thomas; Mueller, Beatrice U.

doi:10.1158/1078-0432.ccr-08-2941

Cited by 100 publications

(92 citation statements)

References 58 publications

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“…In recent reports, it was stated that a better prognosis was observed for biallelic CEBPA mutations compared to monoallelic CEBPA mutations when subjected to a long term follow up study Pastore et al, 2014). In our study single and double CEBPA mutations didn't show any difference in the OS, but was significantly higher than the wild type (P=0.005) which was different from other reports, who showed a significant association for the double over single CEBPA mutation on the prognosis of AML patients (Pabst et al, 2009;Fasan et al, 2014). Polymorphisms observed in this gene on survival analysis revealed no significant association for the OS in any of the cytogenetic groups or in total cases, showing the lack of importance of these variation with respect to survival in AML patients, which was similar to that reported by (Leecharendkeat et al, 2008).…”

Section: Discussioncontrasting

confidence: 99%

Characterization of CEBPA Mutations and Polymorphisms and their Prognostic Relevance in De Novo Acute Myeloid Leukemia Patients

Sarojam

Raveendran²,

Vijay³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 99%

Characterization of CEBPA Mutations and Polymorphisms and their Prognostic Relevance in De Novo Acute Myeloid Leukemia Patients

Sarojam

Raveendran²,

Vijay³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…TRIB-2 could also induce the degradation of CEBPA protein. On the other hands, CEBPA protein interaction with AML1-ETO or c-jun was also known to inhibit the function of CEBPA itself [29][30][31][32][33]. It assumed that there are many factors that regulate the CEBPA expression and its activities in myeloid differentiation process.…”

Section: Discussionmentioning

confidence: 99%

HES-1 and CEBPA mRNA in Chronic and Late Phase (accelerated and blast crisis) of Chronic Myeloid Leukemia (CML) Patients

Rahmawati¹,

Fatmawati²,

Purwanto³

et al. 2017

J Leuk

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Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder of hematopoietic , characterized by Philadelphia chromosome containing BCR-ABL fusion gene. The gene encodes protein with constitutive tyrosine kinase activity result in myeloid proliferation and leads to form an early phase of CML called chronic phase. Unsuccessful treatment will lead to progression of the disease into late phase (accelerated and blast crisis). The mechanisms involving disease progression are still poorly understood. It is assumed that additional genetic event involves in differentiation blocking of myeloid progenitor cells, such as Hes-1 overexpression and CEBPA down regulation. However, study on the expression of these genes in CML patient's samples is still limited. This study aims to measure Hes-1 and CEBPA mRNA in chronic and late phase of CML patients. The peripheral blood mRNA level of Hes-1 was measured in CML patient's sample with BCR-ABL positive both in chronic phase (n=61) and late phase (n=17) using qRT-PCR with GAPDH as internal control. Hes-1 mRNA was statistically higher (p value=0.0) in the chronic phase (mean ± SD=97.8 ± 236.6) compared to those in late phase (mean ± SD=8.5 ± 30.7). In addition, even though CEBPA expression in chronic and late phase were not statistically different (p value=0.1), those in chronic phase (mean ± SD=5.2 ± 16.0) were generally higher compared to those in late phase (mean ± SD=1.7 ± 2.4). Hes-1 expression upregulated in 70.5% of chronic phase patients and in 17.6% of late phase patients, whereas CEBPA expression down regulated in 42.6% of chronic phase patients and in 47.1% in late phase patients. High standard deviation, particularly in mRNA Hes-1 gene expression measurement of the chronic phase, indicated the presence of individual variations in the sample that might be influenced by other genetic factors. This study found that Hes-1 mRNA is significantly higher in peripheral blood of chronic phase than blast crisis CML, whereas CEBPA mRNA is not different.

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“…BP1 may lead to tumor development by regulating Cyclin D1 (Moghaddam et al, 2007). The CEBPA gene has been associated with acute leukemia (Pabst and Mueller, 2009). The relationship between the expression of these genes and the development of colon cancer has not been widely examined.…”

Section: Discussionmentioning

confidence: 99%

Serial analysis of gene expression in adenocarcinoma samples and normal colonic mucosa in a Chinese population

Xl¹,

Gao²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The goal of this study was to identify the differences in gene expression between adenocarcinoma samples and colonic normal mucosa of a Chinese population. Gene expression libraries of adenocarcinoma and normal colonic mucosa were generated by serial analysis of gene expression (SAGE). Expression tags were obtained from sequencing results using the SAGE2000 software. Representative genes of tags were determined based on the SAGEmap from NCBI. Expressed genes were selected and their expression in different libraries was compared using the SPSS 17.0 software. The expression of 78 tags representing 88 types of genes showed significant differences. Compared with normal mucosa, 38 genes showed decreased expression in cancer, whereas the expression of the remaining 50 genes showed significant up-regulation. Expressed tags in SAGE libraries of normal and cancerous tissues were significantly different. Further studies examining these genes, which showed different 12904 X.L. Zhang et al.©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 12903-12911 (2015) expression levels between the 2 tissues, may be used as tumor markers and offer clues for studying the etiopathogenesis of colon cancer.

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Complexity of CEBPA Dysregulation in Human Acute Myeloid Leukemia

Cited by 100 publications

References 58 publications

Characterization of CEBPA Mutations and Polymorphisms and their Prognostic Relevance in De Novo Acute Myeloid Leukemia Patients

Characterization of CEBPA Mutations and Polymorphisms and their Prognostic Relevance in De Novo Acute Myeloid Leukemia Patients

HES-1 and CEBPA mRNA in Chronic and Late Phase (accelerated and blast crisis) of Chronic Myeloid Leukemia (CML) Patients

Serial analysis of gene expression in adenocarcinoma samples and normal colonic mucosa in a Chinese population

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