Complexity and diversity of hepatitis B virus quasispecies: Correlation with long-term entecavir antiviral efficacy

Tong, Jin; Li, Qingling; Huang, Aiping; Guo, Jinsong

doi:10.1016/j.antiviral.2013.06.020

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…Other studies have also shown that dynamic changes in HBV QS complexity and diversity may predict a sustained virologic response to long-term nucleotide acid analogue treatment (9,10). Similar, but not identical, studies from Singapore showed that the evolution of viral diversity increased in HBeAg seroconverters treated with lamivudine (11) and interferon (12).…”

supporting

confidence: 54%

Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection

et al. 2015

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Hepatitis B virus (HBV) infection results in different clinical presentation due to different levels of immune response. Our study aimed to characterize HBV full-length genome quasispecies (QS) in patients with different phases of infection to better understand its pathogenesis. Forty treatment-naive HBV-infected patients were enrolled, including 10 cases of acute hepatitis B (AHB), 9 cases of immunotolerant (IT) HBV carriers, 11 cases of chronic hepatitis B (CHB), and 10 cases of acute-on-chronic liver failure (ACLF). The present study was conducted by clone-based sequencing. QS heterogeneity within each open reading frame was calculated. The mutation frequency index (MFI) and amino acid variations within the large HBsAg, HBcAg, and HBxAg regions were analyzed based on the different infection phases. In total, 606 HBV full-length sequences were obtained. HBV QS had higher heterogeneity in ACLF and CHB than that in IT among chronically infected individuals. AHB patients had the lower QS heterogeneity at onset than those with chronic infection. ACLF patients had the highest frequency of mutations in the core promoter and precore region. A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B. The MFI indicated that specific peptides of the studied regions had more frequent mutations in ACLF. Furthermore, several amino acid variations, known as T-and B-cell epitopes, were potentially associated with the immunoactive phase of infection. More HBV genome mutations and deletions were observed in patients with more severe diseases, particularly in specific regions of the core and preS regions, the clinical significance and mechanism of which need to be further investigated.

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supporting

confidence: 54%

Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection

et al. 2015

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“…Previous studies have extensively profiled the RT drugresistant mutants in CHB patients (7)(8)(9). To our knowledge, there is no report on the natural RT mutations.…”

Section: Discussionmentioning

confidence: 87%

“…Therefore, nucleotide substitutions at the HBsAg region can result in changes in RT sequence and vice versa. Previous studies investigated the relationship between HBV RT variability and therapeutic response or disease progression (7)(8)(9)(10)(11). However, these studies were focused on HBV RT variations under therapeutic conditions.…”

mentioning

confidence: 98%

A strong conservative tendency in HBV transcriptase (RT): a majority of natural RT mutations derived from the S gene

Song

et al. 2016

Liver International

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“…Viral diversity is a measure of the mutation rate or divergence of the viral quasispecies pool from the consensus WT sequence. Previous studies support the notion that decreased viral diversity is associated with higher viral loads39 40 and a higher likelihood of a sustained virological response to long-term NA therapy 41. However, to date there has been limited study of the relationship between viral diversity and serological response to treatment.…”

Section: Discussionmentioning

confidence: 90%

Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B

Bayliss

Yuen

Rosenberg

et al. 2016

Gut

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Complexity and diversity of hepatitis B virus quasispecies: Correlation with long-term entecavir antiviral efficacy

Cited by 8 publications

References 14 publications

Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection

Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection

A strong conservative tendency in HBV transcriptase (RT): a majority of natural RT mutations derived from the S gene

Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B

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