Complexities of Diagnosing Neuroleptic Malignant Syndrome in a Patient with Burn Injury: Could Stimulant Abuse be a Risk Factor?

Laughon, Sarah L.; Sowa, Nathaniel A.; Gala, Gary J.

doi:10.1016/j.psym.2016.05.002

Cited by 4 publications

(8 citation statements)

References 14 publications

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“…Primary conditions in the first group ranged, widely, including trauma, 19,26,27,29,32,34,[40][41][42]52,57,58,64,75,81,83,86,88,89 digestive disease, 25,30,36,37,43,45,46,54,59,60,65,66,77,80,87 malignant tumor, 18,23,24,31,33,35,38,47,51,61,63 and cardiovascular disease 28,39,44,50,53,55,56,…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

“…The physical conditions of trauma patients were relatively severe compared with those with other diseases. The major reason for drug administration was postoperative restlessness, 18,19,25,27,28,[30][31][32][33][34][36][37][38][39]44,46,[52][53][54][55][57][58][59][61][62][63][64][67][68][69][70]72,75,78,81,84,86,89 followed by nausea 19,22,24,33,42,51,55,59,61,73,80,86 and delirium 35,…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

“…develops after administering drugs that block the dopamine receptor. 3,[17][18][19][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]44,46,49,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][66][67][68][69] However, most patients who were administrated bromocriptine, which acts as a dopamine antagonist, showed an improvement in NMS symptoms. [17][18][19]22,24,26,…”

Section: Etiopathogenesismentioning

confidence: 99%

“…The physical conditions of trauma patients were relatively severe compared with those with other diseases. The major reason for drug administration was postoperative restlessness, 18,19,25,27,28,30–34,36–39,44,46,52–55,57–59,61–64,67–70,72,75,78,81,84,86,89 followed by nausea 19,22,24,33,42,51,55,59,61,73,80,86 and delirium 35,40,49,56,71,72,74,82,87,88 (Table 10). Haloperidol caused the highest number of NMS cases, 17–19,25–33,35–40,44,46,53–59,61–64,67,69,74–76,81,82,86,87,89 followed by metoclopramide, 19,24,42,55,60,73,77,86 quetiapine, 52,56,70–72 droperidol, 33,34,51,61 and risperidone 41,52,72,84 (Table 11).…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

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Neuroleptic malignant syndrome in fields other than psychiatry

Shimada

Kase

Nakatsuru

et al. 2023

Oral Science International

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Neuroleptic malignant syndrome (NMS) is an adverse effect of drugs, mainly neuroleptics. It is characterized by problems related to the autonomic nervous system (such as hyperthermia, diaphoresis, and tachycardia) and extrapyramidal symptoms (such as muscle rigidity and tremor). After onset, NMS progresses rapidly and without treatment, becomes life‐threatening. In recent years, NMS has become better recognized, and treatment has improved; most cases are now curable before becoming dangerous. Most NMS reports are from psychiatrists or neurologists; few are from other specialized clinicians. However, nonpsychiatric clinicians, such as surgeons, emergency physicians, orthopedists, and oral surgeons, sometimes must administer neuroleptic drugs. Although NMS is rare, its effects on patients may be debilitating, and this places a heavy burden on clinicians. Thus, not only psychiatrists but also clinicians in various other fields should understand this illness. This article describes NMS in fields other than psychiatry and its diagnosis, risk factors, and treatment strategies.

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Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

“…The physical conditions of trauma patients were relatively severe compared with those with other diseases. The major reason for drug administration was postoperative restlessness, 18,19,25,27,28,[30][31][32][33][34][36][37][38][39]44,46,[52][53][54][55][57][58][59][61][62][63][64][67][68][69][70]72,75,78,81,84,86,89 followed by nausea 19,22,24,33,42,51,55,59,61,73,80,86 and delirium 35,…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

Section: Etiopathogenesismentioning

confidence: 99%

“…The physical conditions of trauma patients were relatively severe compared with those with other diseases. The major reason for drug administration was postoperative restlessness, 18,19,25,27,28,30–34,36–39,44,46,52–55,57–59,61–64,67–70,72,75,78,81,84,86,89 followed by nausea 19,22,24,33,42,51,55,59,61,73,80,86 and delirium 35,40,49,56,71,72,74,82,87,88 (Table 10). Haloperidol caused the highest number of NMS cases, 17–19,25–33,35–40,44,46,53–59,61–64,67,69,74–76,81,82,86,87,89 followed by metoclopramide, 19,24,42,55,60,73,77,86 quetiapine, 52,56,70–72 droperidol, 33,34,51,61 and risperidone 41,52,72,84 (Table 11).…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

See 2 more Smart Citations

Neuroleptic malignant syndrome in fields other than psychiatry

Shimada

Kase

Nakatsuru

et al. 2023

Oral Science International

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show abstract

“…Most authors define neuroleptic malignant syndrome (NMS) as a rare, yet life-threatening, idiosyncratic reaction to medications, mostly but not limited to neuroleptic drugs (dopamine receptor antagonists) [1][2][3] . Though fatal, it is potentially a treatable condition 4 .…”

Section: Introductionmentioning

confidence: 99%

Case Report: Neuroleptic malignant syndrome in a HIV-positive patient

et al. 2020

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We report a 29-year-old, HIV-positive woman being treated with antipsychotic medication for psychosis (Clopixol 200mg intramuscularly monthly, Risperidone 2mg orally daily Haloperidol 2.5mg twice a day), who presented with neuroleptic malignant syndrome. She was also receiving lorazepam and sodium valproate. The patient was referred to our department as she had developed involuntary upper limb movements and simple permanent focal seizure on the lower part of the left hemiface. Clinically the patient had altered consciousness, autonomic dysfunction, and rigidity. Her blood tests showed elevated creatine kinase (1467U/L) but no leucocytosis. We did a thorough workup for other causes of such a presentation. A comprehensive history was taken from the family to exclude other medications used. Her cerebrospinal fluid results were average. Blood tests did not show evidence of infection or other abnormalities. Computed tomography brain was normal. The patient died a few days after the beginning of the attack, which we have also observed in other HIV-female patients. As far as we know, it is the first report about this comorbidity reported in the medical literature.

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Haloperidol

2016

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Complexities of Diagnosing Neuroleptic Malignant Syndrome in a Patient with Burn Injury: Could Stimulant Abuse be a Risk Factor?

Cited by 4 publications

References 14 publications

Neuroleptic malignant syndrome in fields other than psychiatry

Neuroleptic malignant syndrome in fields other than psychiatry

Case Report: Neuroleptic malignant syndrome in a HIV-positive patient

Haloperidol

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