Complexes of myo-inositol-hexakisphosphate (InsP6) with zinc or lanthanum to enhance excretion of radioactive strontium from the body

Ogawa, Kenji; Aoki, Miho; Kadono, Sumi; Odani, Akira

doi:10.1371/journal.pone.0195067

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…The 2013 recommendations advocated a regular low-dose CT scan for patients needing extended follow-up, particularly younger patients. 10 Low-dose CT scan is typically achieved by fixing the tube voltage, lowering the tube current, or reducing the scan length. In addition, the automatic tube current modulation is gaining much attention.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Capabilities of Ultra-low-dose Computed Tomography with a Dose Equivalent to Chest X-ray Radiography

Apkhazava¹,

Nemsadze²,

Chkhaidze³

et al. 2023

Georgian Biomedical News

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Background: Digital chest X-ray radiography (CXR) is the imaging modality of first choice for detecting chest pathology. The average effective dose for CXR (posteroanterior and lateral projection) is 0.10 mSv (range: 0.01 to 0.26 mSv). CT examinations using ultra-low-dose CT (ULDCT) with doses equivalent to CXR examinations allow for detecting chest pathologies and pulmonary nodules with comparable sensitivity to previous standard or low-dose CT techniques. The ULDCT may improve the detection of pulmonary nodules and diagnose a broader range of pathologies. Objectives: This study aims to show the possibility of recognizing and defining a variety of chest pathology using ultralow-dose CT of the chest below 1mSv. Methods: For all patients, after initial CXR, chest ultra-low (ULDCT) and standard-dose CT were performed. The ultra-low dose was achieved by fixing the tube voltage, lowering the tube current, or reducing the scan length. The field size was adapted individually for each patient. In order to reduce radiation exposure, sonograms were not obtained throughout this study. Instead, a conventional laser beam was used to manually set up the start of the scan range (from the lung apex to the whole diaphragm) at the gantry. The CT scan was taken while holding a breath during inspiration with the following parameters: helical scan, 80 kV, 30 mA, 80 0.5 mm collimation, and 0.3 seconds rotation time. No iodinated contrast material was used. Results: We compare the imaging properties of low voltage (80 kV -dosages equal to CXR) CT to a standard voltage (120 kV) CT and CXR in different chest pathologies and lung nodules with diameters from 4 to 30 mm. The sensitivity of ULDCT was 100% compared to CXR. CXR was considered diagnostic in 98% and ULDCT in 100%. The mean perceived confidence for diagnosis was 88±12% with CXR and 98±2% with ULDCT. Ultra-low-dose CT offered higher sensitivity for lesions like consolidation (97%), pleural effusion (95%), fibrosis (92%), and solid pulmonary nodules (91%). Conclusions: ULDCT is a safe and effective method for evaluating lung nodules of different sizes or densities. Keywords: Chest X-ray radiography (CXR); low-dose computer tomography (LDCT); scanogram; ultra-low-dose computer tomography (ULDCT).

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Section: Discussionmentioning

confidence: 99%

Diagnostic Capabilities of Ultra-low-dose Computed Tomography with a Dose Equivalent to Chest X-ray Radiography

Apkhazava¹,

Nemsadze²,

Chkhaidze³

et al. 2023

Georgian Biomedical News

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“…The results demonstrated that Zn-InsP6 adsorbed radiocesium or radiostrontium in vitro. Although Zn-InsP6 did not affect radiocesium in vivo, Zn-InsP6 adsorbed radiostrontium in the gastrointestinal tract, inhibited its absorption from the intestine into the blood, and enhanced its excretion into the feces 9 , 10 . Accordingly, these studies indicated that Chlorella and Zn-InsP6 could work as decorporation agents for radiostrontium.…”

Section: Introductionmentioning

confidence: 85%

“…We have previously conducted studies with the aim to decrease the dose of absorbed radiation in the case of intake incident of radionuclides 8 – 10 . Chlorella , a genus of single-cell green algae that grows in fresh water, is a known health food composed of approximately 1–4% chlorophyll, 55–67% protein, 9–18% dietary fiber, and large amounts of minerals and vitamins 11 .…”

Section: Introductionmentioning

confidence: 99%

Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases

Ogawa

Higashi

Mishiro

et al. 2020

Sci Rep

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[ 223 Ra]RaCl 2 is the first alpha-particle emitting radiopharmaceutical to be used for castration-resistant prostate cancer patients with bone metastases because of its excellent therapeutic effects. [ 223 Ra]RaCl 2 is excreted via the intestine into feces, and some is absorbed from the intestine into the blood, which may be undesirable in terms of the exposure to radiation. Recently, we showed that a complex of myo -inositol-hexakisphosphate (InsP6) with zinc is a useful decorporation agent against radiostrontium. In this study, we hypothesized that Zn-InsP6 could bind to not only strontium but also to radium, and could inhibit the absorption of radium from the intestine. In in vitro binding experiments, Zn-InsP6 showed a high binding affinity for radium. In in vivo biodistribution experiments by intravenous injection of [ 223 Ra]RaCl 2 after treatment of Zn-InsP6, mice treated with Zn-InsP6 showed significantly lower bone accumulation of radioactivity (34.82 ± 1.83%Dose/g) than the mice in the non-treatment control group (40.30 ± 2.78%Dose/g) at 48 h postinjection. These results indicate that Zn-InsP6 bound radium in the intestine and inhibited the absorption of radium into the blood. Therefore, the insoluble Zn-InsP6 complex has high potential to decrease the side effects of [ 223 Ra]RaCl 2 .

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Medical countermeasures against radionuclide contamination: An overview

Grémy

2019

BIO Web Conf.

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Complexes of myo-inositol-hexakisphosphate (InsP6) with zinc or lanthanum to enhance excretion of radioactive strontium from the body

Cited by 4 publications

References 18 publications

Diagnostic Capabilities of Ultra-low-dose Computed Tomography with a Dose Equivalent to Chest X-ray Radiography

Diagnostic Capabilities of Ultra-low-dose Computed Tomography with a Dose Equivalent to Chest X-ray Radiography

Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases

Medical countermeasures against radionuclide contamination: An overview

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