Complexation, thermal and catalytic studies of N-substituted piperazine, morpholine and thiomorpholine with some metal ions

Kacan, M.; Türkyılmaz, Murat; Karabulut, Ferhat; Altun, Özlen; Βaran, Yakup

doi:10.1016/j.saa.2013.09.031

Cited by 9 publications

(4 citation statements)

References 38 publications

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“…The patients and control groups were comparable in terms of sex and smoking status. However, males were found to have 4.9 times higher risk of having lung cancer consistent with the results of Kacan et al [21] Besides, smoking, particularly in parallel to male sex, is one of the most causes for lung cancer. In our study, 84.6% of the patients were smokers.…”

Section: Discussionsupporting

confidence: 89%

The role of galectin-3 and its genetic variants in tumor risk and survival of patients with surgically resected early-stage non-small cell lung cancer

Terzioglu-Usak¹,

Horozoglu²,

Demirkol³

et al. 2021

Turk Gogus Kalp Dama

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Background: The aim of this study was to investigate the possible relationship between galectin-3 gene variants, serum level, gene expression level, and the risks and survivals of resectable non-small cell lung cancer patients. Methods: The rs4644 and rs4652 variants of galectin-3 were genotyped by TaqMan single nucleotide polymorphism assay using genomic deoxyribonucleic acid isolated from the peripheral blood of 65 (54 males, 11 females; mean age: 60.1±11.9 years; range, 34 to 83 years) with Stage IA-IIIA non-small cell lung cancer who underwent primary surgical treatment and 95 healthy individuals (48 males, 47 females; mean age: 53.9±13.5 years; range, 32 to 87 years) between March 2017 and September 2018. Circulating galectin-3 levels in serum samples of the patient and control groups were assessed by enzyme-linked immunosorbent assay. Messenger ribonucleic acid expression of galectin-3 in tumor and surrounding tissues of the patient group was examined by real-time quantitative polymerase chain reaction. Both predictive and prognostic significance of the results were analyzed. Results: The presence of angiolymphatic invasion was significant in the patients with rs4652 AA genotype (p=0.04). Serum galectin-3 levels were significantly higher in the patients than the controls (p<0.0001). The patients with rs4644 CA/CC (p<0.0001 and p<0.0001) and rs4652 AA/AC (p=0.001 and p<0.0001) genotypes had higher serum galectin-3 levels than their corresponding controls. Serum galectin-3 levels increased in the presence of vascular invasion in patients with both rs4644 AC (p=0.03) and rs4652 AC (p=0.019) genotypes. The receiver operating characteristic curve suggested serum galectin-3 level as a strong predictive marker for the patient group with a cut-off value of 17.089 ng/mL (area under the curve: 0.910±0.04; 95% confidence interval: 0.832-0.988; p<0.001). Univariate analysis revealed the association of lower serum galectin-3 levels with better survival (p=0.048). Multivariate survival analysis showed that only high serum galectin-3 levels tended to be related to survival of the patients (hazard ratio: 5.106; 95% confidence interval: 0.956-27.267; p=0.056). Conclusion: The presence of galectin-3 gene variants may lead to histopathological differences among patients with non-small cell lung cancer. Serum galectin-3 level may be a valuable diagnostic biomarker and be associated with survival of these patients.

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Section: Discussionsupporting

confidence: 89%

The role of galectin-3 and its genetic variants in tumor risk and survival of patients with surgically resected early-stage non-small cell lung cancer

Terzioglu-Usak¹,

Horozoglu²,

Demirkol³

et al. 2021

Turk Gogus Kalp Dama

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“…A period of slow losses of weight followed by further losses of chlorides and formation of oxides was complete by about 725 °C. No metal thiocyanates, sulfides, or sulfates were detected in the course of the decomposition as was reported in the case of thermal decomposition of metal chloride thiomorpholine complexes . On this basis, it can be concluded that the thermal decompositions of 1 and 2 occur through breaking of metal–sulfur bonds.…”

Section: Resultssupporting

confidence: 61%

“…No metal thiocyanates, sulfides, or sulfates were detected in the course of the decomposition as was reported in the case of thermal decomposition of metal chloride thiomorpholine complexes. 41 On this basis, it can be concluded that the thermal decompositions of 1 and 2 occur through breaking of metal−sulfur bonds. The residual masses of 34.10% (PtO) and 36.10% (PdO) for 1 and 2, respectively, were caused by simultaneous formation of nitrogen, carbon, and sulfur species (NO, CO, CO 2 , H 2 S) and Cl 2 (Figures S1 and S2 in the Supporting Information).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Influence of C–H/X (X = S, Cl, N, Pt/Pd) Interactions on the Molecular and Crystal Structures of Pt(II) and Pd(II) Complexes with Thiomorpholine-4-carbonitrile: Crystallographic, Thermal, and DFT Study

Ristić

Blagojević

Janjić

et al. 2020

Crystal Growth & Design

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Pt(II) and Pd(II) complexes (1 and 2, respectively) with thiomorpholine-4-carbonitrile (TM-CN), an N-substituted thiomorpholine derivative, were synthesized from tetrachlorido precursors in water. Structural analysis has shown that 1 represents the first monomeric metal complex with this ligand type with an axial M–S bond with respect to the TM-CN ring chair conformation, while in 2 a typical equatorial M–S bond position with respect to the ring chair conformation was observed. A detailed DFT investigation revealed that axial conformers are more stable for molecular forms of both metals, while intermolecular interactions in the crystals stabilize the axial conformer for Pt(II) and the equatorial conformer for Pd(II). The magnitude of this stabilization in the case of 2 is large enough to change the most stable axial conformer in the molecular form to the equatorial conformer in the crystal. Further investigation of the strength of individual intermolecular interactions revealed significant differences of some interactions between the two structures. The likely cause of the difference in the crystal structures of experimentally obtained complexes is the fact that 1 and 2 exhibit different dominant interactions: C–H/M and C–H/S are more dominant in 1 and C–H/Cl interactions are more dominant in 2. In addition, DFT calculations have shown that while the axial position of the Pt–S bond with respect to the ring chair conformation results in a significantly shorter C–H/Pt interaction distance than that in the hypothetical equatorial conformer, there is very little difference in C–H/Pd interaction distances in conformers with axial and equatorial positions of Pd–S bond with respect to the ring chair conformation.

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“…In addition to pH‐response, the influence of Cu (II) concentration was studied. Morpholino moieties are bidentate ligands for Cu (II), forming a coordination complex with square planar geometry, where a Cu(II) ion is complexed with two morpholino ligands (CuL 2 ) . The effect of increasing Cu (II) concentrations on the LCST behavior of a morpholino‐containing system ( entry 5 , Table ) is shown (Figure B).…”

Section: Resultsmentioning

confidence: 99%

Responsive Thiolactone-DerivedN-Substituted Poly(Urethane-Amide)s

Espeel

Celasun

Omurtag

et al. 2017

Macromol. Rapid Commun.

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AB' type monomers containing a thiolactone unit and vinyl ether moiety have been prepared with high yields. Aminolysis of the thiolactone moiety generates the corresponding thiol in situ, and upon UV-irradiation, radical polyaddition occurs in the same medium, yielding linear poly(amide-urethane)s with different side chain residues and (Poly(Ethylene Oxide)) PEO-like backbone. Moreover, these unique polymers feature lower critical solution temperature behavior in water. Systematic modification of the responsive polymers reveals the influence of the variation of the side chains and the backbone structure on the corresponding solubility properties. In selected cases, multiresponsive polymers have been developed, which also respond to pH and metal concentration.

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Complexation, thermal and catalytic studies of N-substituted piperazine, morpholine and thiomorpholine with some metal ions

Cited by 9 publications

References 38 publications

The role of galectin-3 and its genetic variants in tumor risk and survival of patients with surgically resected early-stage non-small cell lung cancer

The role of galectin-3 and its genetic variants in tumor risk and survival of patients with surgically resected early-stage non-small cell lung cancer

Influence of C–H/X (X = S, Cl, N, Pt/Pd) Interactions on the Molecular and Crystal Structures of Pt(II) and Pd(II) Complexes with Thiomorpholine-4-carbonitrile: Crystallographic, Thermal, and DFT Study

Responsive Thiolactone-DerivedN-Substituted Poly(Urethane-Amide)s

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